Tracheal tubes lubricated with water to reduce sore throat after intubation: A randomized non-inferiority trial

Kim, Eugene; Yang, Seung Min; Kwak, Sang Gyu; Park, Seoyeong; Bahk, Jae Hyon; Seo, Jeonghwa

doi:10.1371/journal.pone.0204846

Cited by 7 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, indwelling endotracheal tube is often required after the surgeries of oral malignant tumor. However, the tracheal tube is also a source of stimulation, and retention of tracheal catheter can cause patients' cough, agitation, increased blood 4 BioMed Research International pressure and heart rate, and other adverse reactions [7]. These nociceptive stimuli not only adversely affect the body's physiological function but also significantly delay the patient's recovery process and even can produce more serious surgical complications.…”

Section: Discussionmentioning

confidence: 99%

Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery

Wang

Zhang

Huang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

The aim of the investigation is to clarify the beneficial sedative effects for patients with postoperative intubation in the intensive care unit (ICU) after oral and maxillofacial surgery. Forty patients with postoperative intubation were divided into two groups in method of random number table: midazolam group and dexmedetomidine group. The Ramsay score, the behavioral pain scale (BPS) score, SpO 2 , HR, MAP, and RR were recorded before sedation (T0), 30 minutes (T1), 1 hour (T2), 2 hours (T3), 6 hours (T4), and 12 hours (T5) after dexmedetomidine or midazolam initiation in intensive care unit, and 10 minutes after extubation (T6). The rate of incidences of side effects was calculated. Sedation with midazolam was as good as standard sedation with dexmedetomidine in maintaining target sedation level. The BPS score in the midazolam group was higher than that in the dexmedetomidine group. The time of tracheal catheter extraction in the dexmedetomidine group was shorter than that in the midazolam group (p ≤ 0:001). The incidence of bradycardia in the dexmedetomidine group was higher than that in the midazolam group (p = 0:028). There was no statistically significant difference in the incidence of hypotension between the two groups (p = 0:732). The incidence of respiratory depression of group midazolam was higher than that of group dexmedetomidine (p = 0:018). The incidence of delirium in the dexmedetomidine group was significantly lower than that in the midazolam group, and the difference was statistically significant (p = 0:003). Dexmedetomidine and midazolam can meet the needs for sedation in ICU patients. And dexmedetomidine can improve patients' ability to communicate pain compared with midazolam.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery

Wang

Zhang

Huang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The participants (58 people) were categorized into 2 equal groups considering alpha at 0.05, beta at 0.2, P1 at 0.4, and P2 at 0.1. According to the study of Kim et al (12) and based on the following formula, sample size was calculated:…”

Section: Methodsmentioning

confidence: 99%

The Effect of Softening of Endotracheal Tubes on the Decrement of Postoperative Hoarseness and Sore Throat

et al. 2022

View full text Add to dashboard Cite

Background: Hoarseness, cough, and sore throat are the most prevalent complications after removing patients’ endotracheal tube and general anesthesia. Various methods have been proposed to reduce these complications after intubation. Objectives: The present study aimed to assess the effect of softening the endotracheal tube with normal warm saline on reducing post-intubation complications such as sore throat and hoarseness. Methods: This double-blind, randomized controlled trial was performed on patients undergoing general anesthesia at Rasoul Akram and Firoozgar hospitals in Tehran, Iran. In the present study, 58 patients were randomly divided into 2 groups of 29 patients. All patients underwent the same premedication with fentanyl and lidocaine. Anesthesia was induced with propofol and atracurium. Three to 5 minutes after atracurium injection, the laryngoscopy test was performed. Randomly, some patients were intubated with a thermally softened endotracheal tube, and some were intubated with a normal tube. At the end of the operation, when the spontaneous breathing was adequate, and the patients could carry out oral instructions, the endotracheal tube was removed immediately after suctioning. All patients were evaluated for sore throat and hoarseness before discharge from recovery and 24 hours after surgery. The obtained data were analyzed using SPSS software package version 25. Results: The mean incidence of sore throat in recovery in the intervention group (20.7%) decreased compared to the control group (75.8%). Moreover, the mean incidence of hoarseness in the intervention group (17.2%) decreased in comparison to the control group (41.4%, P < 0.029). Based on the data of our study, we observed that 24 hours after surgery, the mean incidence of sore throat among the patients of the intervention group was significantly lower compared to the control group, where patients in the intervention group did not feel any sore throat (P < 0.002). We also observed that 24 hours after surgery, the amount of hoarseness in the intervention group (3.4%) also decreased compared to the control group (24.1%, P < 0.022). Conclusions: Based on the results, it can be concluded that thermal softening of the endotracheal tubes with normal warm saline before intubation could be significantly effective in decrement of sore throat and hoarseness during recovery and 24 hours after surgery.

show abstract

“…The comparators represented non‐analgesic methods or active controls as long as they were administered before endotracheal intubation. Non‐analgesic methods included placebo and agents without known analgesic potency such as saline as well as usual care and no pre‐treatment . Active controls included drugs with known prophylactic effects against postoperative sore throat, such as topical lidocaine and corticosteroids.…”

Section: Methodsmentioning

confidence: 99%

“…Non-analgesic methods included placebo and agents without known analgesic potency such as saline as well as usual care and no pre-treatment. 25 Active controls included drugs with known prophylactic effects against postoperative sore throat, such as topical lidocaine and corticosteroids. We placed no restriction on the dose or number of doses of the comparators.…”

Section: Intervention Eligibilitymentioning

confidence: 99%

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Kuriyama

Nakanishi

Kamei

et al. 2020

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Background Postoperative sore throat is a leading undesirable postoperative outcome. Ketamine is an N‐methyl‐d‐aspartate receptor antagonist and its topical application is used for chronic pain and oral/throat indications. We conducted a systematic review to assess the efficacy of preoperative, topical ketamine application for preventing postoperative sore throat. Methods We searched MEDLINE, EMBASE, and CENTRAL through September 23, 2019 for randomized controlled trials in which at least one intervention was topical ketamine to prevent postoperative sore throat in adults undergoing endotracheal intubation. The primary outcome was the incidence of sore throat at 24 hours postoperatively. The comparators were non‐analgesic controls (placebo, no treatment, or usual care) or active agents. We pooled the data using a random‐effects model. Results We included 41 randomized controlled trials involving 3784 participants. Topical ketamine was associated with reduced incidence of sore throat at 24 hours postoperatively compared to non‐analgesic methods (risk ratio, 0.45; 95% CI, 0.37‐0.54; P < .001). We found significant publication bias, but the results remained unchanged with a trim‐and‐fill analysis. Trial sequential analysis (TSA) suggested that the efficacy of topical ketamine was adequate (TSA‐adjusted 95% CI, 0.33‐0.56). The GRADE quality for this evidence was moderate. Topical ketamine was inferior to a combination of nebulized ketamine and clonidine in preventing postoperative sore throat. Conclusions Preoperative, topical ketamine application may be more effective than non‐analgesic methods in preventing postoperative sore throat. The number of studies did not suffice to determine the place of topical ketamine among agents to prevent postoperative sore throat.

show abstract

Tracheal tubes lubricated with water to reduce sore throat after intubation: A randomized non-inferiority trial

Cited by 7 publications

References 45 publications

Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery

Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery

The Effect of Softening of Endotracheal Tubes on the Decrement of Postoperative Hoarseness and Sore Throat

Topical application of ketamine to prevent postoperative sore throat in adults: A systematic review and meta‐analysis

Contact Info

Product

Resources

About