1993
DOI: 10.1152/jappl.1993.75.4.1728
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Tracheobronchial dilation during isocapnic hypoxia in conscious humans

Abstract: To assess the effects of isocapnic hypoxia on the pharynx, glottis, extrathoracic trachea (ET), intrathoracic trachea (IT), and main bronchi (MB), we measured the cross-sectional areas of these airways by acoustic reflection technique in 15 healthy volunteers. Measurements were made during tidal volume breathing while subjects were normoxic [arterial O2 saturation (SaO2) > 95%] or were made hypoxic by a rebreathing procedure. Under hypoxemic conditions, airway cross-sectional areas increased significantly at E… Show more

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Cited by 13 publications
(6 citation statements)
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“…In hypoxia, the +/+ animals exhibited significant acinar airway dilatation as well as increased lung air and tissue volumes and surface areas, consistent with airway smooth muscle relaxation and compensatory alveolar growth, respectively. Hypoxia reduces airway smooth muscle tone partly via limiting calcium entry into cells (Vannier et al, 1995, Wetzel et al, 1992, Julia-Serda et al, 1993); the bronchodilation effect extends throughout the bronchial tree down to the distal intra-acinar airways as seen in fa/fa lungs where the normally smaller alveolar ducts became more dilated in hypoxia. The hypoxia-induced gains in septal volumes and surface areas were consistently lower in fa/fa compared to +/+ lungs, especially for type II epithelium volume.…”
Section: Discussionmentioning
confidence: 99%
“…In hypoxia, the +/+ animals exhibited significant acinar airway dilatation as well as increased lung air and tissue volumes and surface areas, consistent with airway smooth muscle relaxation and compensatory alveolar growth, respectively. Hypoxia reduces airway smooth muscle tone partly via limiting calcium entry into cells (Vannier et al, 1995, Wetzel et al, 1992, Julia-Serda et al, 1993); the bronchodilation effect extends throughout the bronchial tree down to the distal intra-acinar airways as seen in fa/fa lungs where the normally smaller alveolar ducts became more dilated in hypoxia. The hypoxia-induced gains in septal volumes and surface areas were consistently lower in fa/fa compared to +/+ lungs, especially for type II epithelium volume.…”
Section: Discussionmentioning
confidence: 99%
“…For example, sympathetic responses and catecholamine release would tend to bronchodilate, whereas vagal responses cause constriction. In addition, changing (18,26,33), within species with different experimental protocols (8,10,25), and between in vivo and in vitro preparations (5,6,24,28). To distinguish the direct effects of alveolar hypoxia on lung and airway mechanical function from the confounding effects of systemic hypoxemia, we have used a model in which the lungs of anesthetized dogs can be independently ventilated with different gas mixtures and the respiratory system impedance of each side can be determined separately.…”
Section: Discussionmentioning
confidence: 99%
“…For example, there is evidence of airway constriction to hypoxemia in intact dogs (18,26) but bronchodilation in minipigs (33). In humans, hypoxia has been reported to cause bronchoconstriction (25), to cause bronchodilation (10), and to have no effect (8). Furthermore, there is poor agreement between in vivo and in vitro results.…”
mentioning
confidence: 99%
“…In the lower airways a tracheobronchial dilatation is seen during isocapnic hypoxia (321). Nasal decongestants have been evaluated by acoustic rhinometry, as a simple method to assess the effect of different compounds, dosages, and dosage forms (284, 314, 318, 322).…”
Section: Other Clinical Uses Of Acoustic Rhinometry and Acoustic Reflmentioning
confidence: 99%