1971
DOI: 10.1016/0002-9343(71)90338-x
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Tracheobronchial secretions

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Cited by 70 publications
(24 citation statements)
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“…Albumin has a molecular mass of 66 kDa and is the most abundant protein in serum, accounting for about 60% of the total serum protein, yielding concentrations ranging between 20 and 36 mg/ml in FBS and 35 and 52 mg/ml in human serum (HS) (48). Albumin is also present in respiratory secretions, and its abundance increases during inflammation (49)(50)(51). In addition, previous work by Bellalou et al showed that growth of B. pertussis with albumin-supplemented SSM resulted in a high level of ACT in the supernatant (52).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Albumin has a molecular mass of 66 kDa and is the most abundant protein in serum, accounting for about 60% of the total serum protein, yielding concentrations ranging between 20 and 36 mg/ml in FBS and 35 and 52 mg/ml in human serum (HS) (48). Albumin is also present in respiratory secretions, and its abundance increases during inflammation (49)(50)(51). In addition, previous work by Bellalou et al showed that growth of B. pertussis with albumin-supplemented SSM resulted in a high level of ACT in the supernatant (52).…”
Section: Resultsmentioning
confidence: 99%
“…To address the role of albumin during human infection with B. pertussis, we tested human respiratory secretions for the ability to affect the amount and distribution of ACT. Respiratory secretions contain serum components, notably albumin, and the concentrations of these components increases during inflammation (49)(50)(51). Bronchoalveolar lavage (BAL) was performed on 7 patients with interstitial lung disease or bronchiectasis, and the resulting samples were pooled and concentrated as described.…”
Section: Figmentioning
confidence: 99%
“…lung diseases. In fact, viscous mucus secretions may be responsible for part of the airway obstruction [17,18]. The precise mechanism for the mucolytic activity of azelastine observed in mice and rats (this study), in rabbits [27], guinea pigs [19], and dog [20] is not yet known.…”
Section: Discussionmentioning
confidence: 97%
“…Excessive respiratory secretions and mucus plugs are obvious problems and may contribute to the Address for correspondence: Dr. Naresh Chand, Wallace Laboratories, P.O. Box i001, Cranbury, NJ 08512, USA pathogenesis and mortalities in asthma and in chronic obstructive respiratory diseases [17,18]. Azelastine lowers the viscosity of tenacious mucus during late-phase asthmatic responses in guinea pigs [19].…”
Section: Introductionmentioning
confidence: 99%
“…This "mucociliary escalator" begins in the regions of the respiratory bronchioles. The response of the respiratory mucociliary system to irritants has been previously reviewed (9,10). The lower airways consisting of bronchioles and alveoli do not contain mucin-producing cells in their epithelium, and consequently the extracellular lining is quite different in composition from that of the upper airways.…”
Section: The Extracellular Liningmentioning
confidence: 99%