Tracheobronchopathia osteochondroplastica

Castella, J.; Puzo, C.; Cornudella, R.; Curell, R.; Tarres, J.

doi:10.1159/000194416

Cited by 16 publications

(10 citation statements)

References 3 publications

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“…1 Chronic bronchorrhea has been described in a patient with TPO. 58 In one review of 15 patients with TPO, the mean age was 63.5 years, and the most common symptoms were cough (66%), hemoptysis (60%), dyspnea on exertion (53%), and wheeze (30%). Thirteen percent of the patients were asymptomatic.…”

Section: Clinical Featuresmentioning

confidence: 99%

Tracheobronchopathia Osteochondroplastica

Prakash¹

2002

Seminars in Respiratory and Critical Care Medicine

102

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Tracheobronchopathia osteochondroplastica (TPO) is an uncommon benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. The nodules originate in the airway cartilages and thus typically spare the posterior membranous wall of the airways. The disorder is more common in men and the diagnosis is usually made in the fourth through sixth decades of life. There is no relationship to smoking or other systemic disorders. The disease is manifested by chronic cough and wheezing, which frequently lead to the mistaken diagnosis of asthma. Other pulmonary symptoms include dyspnea and hemoptysis. One of the complications is the increased incidence of recurrent respiratory infections. The pulmonary symptoms and complications are the consequence of narrowing and thickening of the airway walls. Even though roentgenologic imaging studies may indicate the diagnosis, bronchoscopy is the most definitive diagnostic test. The bronchoscopic appearance alone is diagnostic of the disease, and biopsy of the airway lesions is seldom, if ever, required. Although there is no specific therapy for this disorder, management of tracheobronchopathia osteochondroplastica includes bronchodilators, prompt treatment of pulmonary infections, and bronchoscopic dilatation when indicated.

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Section: Clinical Featuresmentioning

confidence: 99%

Tracheobronchopathia Osteochondroplastica

Prakash¹

2002

Seminars in Respiratory and Critical Care Medicine

102

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“…[1][2][3][4][5][6] Significant rigidity of the affected areas of the tracheobronchial tree contributes to the respiratory problems. The characteristic feature of TPO is the presence of multiple ossified or cartilaginous sessile nodules in the submucosa of the trachea and bronchi.…”

mentioning

confidence: 99%

Tracheobronchopathia Osteochondroplastica

Nienhuis

Prakash

Edell

1990

Ann Otol Rhinol Laryngol

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Tracheobronchopathia osteochondroplastica is an unusual disease of obscure causation characterized by cartilaginous or bony outgrowths into the lumen of the tracheobronchial tree. Our retrospective review of 15 patients, 8 of whom were women, revealed a mean age of 63.5 years. The most common symptoms were cough (66%), hemoptysis (60%), dyspnea on exertion (53%), and wheeze (30%). Thirteen percent of the patients were asymptomatic. Chest radiography was not helpful in the diagnosis. Tracheal tomography revealed typical beaded intraluminal calcification in 4 of the 12 patients tested. Mirror laryngoscopy initially revealed the abnormalities in 30% of the patients, and bronchoscopy confirmed the diagnosis and determined the extent of the disease in all patients. Even though upper airway involvement has been thought to be uncommon, 40% of our patients demonstrated abnormalities of the larynx and upper trachea. Histologic confirmation of heterotopic bone formation was obtained in 60% of the patients. Pulmonary function tests showed mild obstructive lung disease. There were no deaths directly attributable to the disease. Treatments attempted included cryotherapy, laser excision, external beam irradiation, and bronchoscopic removal of the obstructing lesions.

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“…The ossification is usually confined to preexisting bronchial or tracheal cartilage, but ossous metaplasia can occur [1]. In contrast, the tumor reported herein is a well-circumscribed single nodule without cartilage, localized in peripheral lung parenchyma; thus, unlikely to be mistaken for tracheobronchopathia osteochondroplastica.…”

Section: Discussionmentioning

confidence: 73%

Lung osteoma—a new benign lung lesion

et al. 2006

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Extraskeletal osteomas have not been described in the lung. Tumors with osseous elements can be found, such as hamartoma and amyloid tumor, and reactive lesions such as osseous metaplasia. A 39-year-old male patient was treated for multiple myeloma and got a bone marrow transplantation 2 years and a few months before he presented with a solitary well-circumscribed tumor in the right middle lobe. The patient underwent surgical resection. The tumor presented with a fibrous capsule and consisted of mature bone trabecules. Within the tumor, fatty tissue was seen. There were small bone spicules interpreted as areas of new bone formation and appositional growth. No amyloid deposition, no immature epithelial tubules as in hamartomas, and no normal lung structure as in osseous metaplasia were seen. Within the osseous elements, a positive reaction was seen with antibodies for osteonectin, whereas the reaction for calcitonin was negative. To the best of our knowledge, this is the first case of an osteoma being reported in the lung looking like any other extraskeletal osteoma. This tumor might have been induced by circulating stem cells; however, due to autologous bona marrow transplantation, this cannot be proven.

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Tracheobronchopathia osteochondroplastica

Cited by 16 publications

References 3 publications

Tracheobronchopathia Osteochondroplastica

Tracheobronchopathia Osteochondroplastica

Tracheobronchopathia Osteochondroplastica

Lung osteoma—a new benign lung lesion

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