Tracheopathia Osteoplastica

Bowen, D.

doi:10.1136/jcp.12.5.435

Cited by 28 publications

(18 citation statements)

References 6 publications

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“…Another interesting feature is the observation of bone marrow in the osseous nodules and ridges of tracheopathia osteoplastica (Dalgaard, 1947;Bowen, 1959;and present case), which has likewise been observed in other metaplastic lesions: Micheli and Fogliati (1952) (Willis, 1958); and personal observations include bone marrow in bone of abdominal scar tissue, osteoma cutis, and silicotic nodules of lung. The haemopoietic tissue in all these different sites can only have arisen by a metaplastic process from dedifferentiated, "uncommitted " mesenchymal cells, and hence the finding of bone marrow within the bone of tracheopathia osteoplastica would appear to lend support to the interpretation of a metaplastic causation.…”

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confidence: 73%

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Tracheopathia Osteoplastica

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confidence: 73%

“…It is characterized by the development of multiple small, cartilaginous and bony islets in the connective tissue of the mucosa and submucosa of the trachea and, to a lesser extent, of the main bronchi. Dalgaard (1947) collected about 90 cases from the literature, and Bowen (1959) (Fig. 1).…”

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confidence: 99%

Tracheopathia Osteoplastica

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“…Gegen Dalgaards Theorie spricht, dass die Tracheahinterwand, an der sich die meisten elastischen Fasern befinden, nie Knoten aufweist. Ebenso konnte his tologisch kein elastischer Knorpel nach gewiesen werden, und die Knoten zeigen keine Verbindung zu den elastischen Fa serbänden [14].…”

Section: Kausale Pathogeneseunclassified

Tracheopathia osteoplastica

Tóth

2012

Pathologe

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Tracheopathia osteoplastica is a very rare disease of the tracheobronchial tree with unknown origin and etiopathogenesis. The characteristic features are intramucosal nodules in the tracheal and/or bronchial mucosa. The clinical symptoms are unspecific and in most of the cases are consequences of airway stenosis. A collective of patient cases (4 tracheobronchial biopsies and 16 autopsy cases) was established to study the histology of tracheopathia osteoplastica and consisted of surgical pathology specimens (biopsies) and autopsy material. The study revealed two different types of tracheal ossification and nodule formation: (1) degenerative changes with nodule formation and ossification (tracheopathia osteoplastica tuberosa) and (2) diffuse degeneration of the tracheal cartilage with ossification of the outer third of the cartilaginous rings (tracheopathia osteoplastica peripherica). The histological changes indicate that tracheopathia osteoplastica is a type of sclerosing tracheopathy but the degenerative focus is at an unusual place (in the middle of the cartilage). No type of new cartilage formation was found in any of the cases.

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“…In Anbetracht der geringen Fallzahl bei den einzelnen Publikationen obliegen die Angaben zur möglichen Pathophysiologie wohl eher der Spekulation: Chronische Infekte, genetische Disposition, chemische und mechanische Irritationen, Störungen des Kalziumstoffwechsels, Amyloidose, Tuberkulose und sogar eine Lues [8] sind als ätiologische Faktoren genannt worden (Übersicht bei [22] …”

Section: äTiologieunclassified

Klinische Aspekte der Tracheopathia osteoplastica

Neumann

Kasper

Schultz-Coulon

2001

HNO

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Tracheopathia osteoplastica is a rare condition of the tracheobronchial tree characterized by the formation of multiple osseous or cartilaginous submucosal nodules which protrude into the lumen. Clinical features, pathological-anatomical, and radiological findings are described and discussed on the basis of three recent cases and a literature review.Two female patients (age 56 and 62 years) and one male (age 44 years) presented with recurrent tracheobronchitis, a "difficult intubation" at the time of an emergency situation requiring tracheostomy. The diagnosis was confirmed by tracheoscopy. CT scans showed radiodense nodular thickening of the tracheal wall compromising the lumen in all patients, whereas plain chest radiography revealed scalloped linear calcification in only one case. Histologically the nodules consisted of lamellar-type bone covered by normal mucosa. None of the patients needed therapeutic measures as there was no impairment of ventilatory function. The long-term observations (>15 years) of a few authors suggest that the disease is of benign course and does not deteriorate.

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Tracheopathia Osteoplastica

Cited by 28 publications

References 6 publications

Tracheopathia Osteoplastica

Tracheopathia Osteoplastica

Tracheopathia osteoplastica

Klinische Aspekte der Tracheopathia osteoplastica

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