The medical complexity of children who undergo pediatric HTx is increasing, and comorbidities including deconditioning, poor nutrition, muscular weakness, airway anomalies, and pulmonary dysfunction render a proportion of these children ventilator-dependent prior to undergoing HTx. [1][2][3][4][5][6] Positive pressure ventilation improves cardiac output and reduces left ventricular afterload, myocardial oxygen demand, and respiratory muscle oxygen consumption. 7,8 However, prolonged intubation in children decreases the patient's comfort, limits mobility, and delays development of oropharyngeal skills. Furthermore, inadvertent extubation, vocal cord dysfunction,