Trachyspermum ammi Seeds Supplementation Helps Reverse Scopolamine, Alprazolam and Electroshock Induced Amnesia

Abstract

The present study was designed to explore the beneficial effects of successive 10 days administration of Trachyspermum ammi seed's powder (TASP) along with diet (at the dose of 0.5%, 1.0% and 2.0% w/w) on learning and memory of mice. A total of 306 mice divided in 51 equal groups were employed in the study. Passive avoidance paradigm (PAP) and Object recognition Task (ORT) were employed as exteroceptive models. The brain acetylcholinesterase activity (AChE), serum cholesterol, brain monoaldehyde (MDA), brain reduced glutathione (GSH) and brain nitrite were estimated and Alprazolam, Scopolamine and Electroshock induced amnesia was employed to describe the actions. Treatment of TASP significantly increased step down latency of PAA and significantly increased discrimination index of ORT in groups with or without amnesia when compared to respective control groups. Furthermore, TASP administration resulted in significant fall in brain AChE activity, brain MDA level and brain nitrite level with simultaneous rise in brain GSH level, thereby decreased oxidative damage. A significant decrease in serum cholesterol was also observed. Ajowan supplementation may prove a remedy for the management of cognitive disorders owing to have pro-cholinergic, antioxidant and hypo-lipidemic activities.

Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

“…In this study, we showed that scopolamine significantly reduced the spatial working memory of rats measured via the Y‐maze test. This agrees with previous reports that scopolamine induces cognitive deficiencies in animals (Akinyemi et al., ; Kwon et al., ; Soni & Parle, ). The Y‐maze test is an experimental behavioral procedure widely used to assess immediate spatial working memory, which is one of the indices of overall cognitive function (de Bruin et al., ; Hamlin, Windels, Boskovic, Sah, & Coulson, ).…”

Brain targeted oral delivery of doxycycline hydrochloride encapsulated Tween 80 coated chitosan nanoparticles against ketamine induced psychosis: behavioral, biochemical, neurochemical and histological alterations in mice

“…Acetylcholine is a one of the main neurotransmitter involved in formation of memory, which is degraded by AChE enzyme (Soni & Parle, 2017 ). Ketamine has already been established to reduce the concentration of acetylcholine in hippocampal region of brain by the blockade of nAChR with increase of AChE activity related to cause cognitive symptoms of psychosis (Chatterjee et al., 2012 ).…”

“…Memory session was performed on next day and the animal was observed for 300 s to evaluate the cognitive function of animals. Animals were not provided shocks during the memory session (Soni and Parle, 2017 ).…”

Effect of Alkaloid Extract from African Jointfir (Gnetum africanum) Leaves on Manganese‐Induced Toxicity in Drosophila melanogaster

“…NO content in the whole fly tissue homogenate was estimated using the Greiss reagent spectrophotometric based method [36] with slight modifications. Briefly, the reaction mixture consist of 150 μ L of tissue homogenate, 50 μ L of distilled water, and 600 μ L of Greiss reagent (0.1% N -(1-naphthyl)-ethylenediamine dihydrochloride, 1% sulfanilamide, and 2.5% phosphoric acid).…”