Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia: An ERP Study

Giordano, Giulia; Brando, Francesco; Perrottelli, Andrea; Lorenzo, Giorgio Di; Siracusano, Alberto; Giuliani, Luigi; Pezzella, Pasquale; Altamura, Mario; Bellomo, Antonello; Cascino, Giammarco; Casale, Antonio Del; Monteleone, Palmiero; Pompili, Maurizio; Galderisi, Silvana; Maj, Mario

doi:10.3389/fpsyt.2021.790745

Cited by 12 publications

(6 citation statements)

References 106 publications

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“…The resulting combination of EEG alterations, in chronic patients with schizophrenia, was associated with real-life functioning and with illness-related variables which have an impact on functional outcomes, such as cognitive impairment, depression, and negative symptoms, at 4-year follow-up [ 4 , 6 ]. Previous research identified alterations of several EEG indices in SCZs, which are related to different brain functions and associated with different illness features influencing the outcome or with the outcome itself [ 25 – 29 ]. However, despite the results of these studies, no EEG index has been implemented in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Several quantitative resting-state EEG and event-related potentials (ERP) alterations have been reported in SCZs in different stages of the illness and many of them are associated with psychopathology, cognitive impairment, and functional outcome [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…As to determinants of functional outcome, cognitive impairment was found to be associated with alterations in multiple resting-state frequency bands [ 29 , 37 ], abnormalities of P300 amplitude and latency [ 27 , 37 , 38 ], deficit in both N100 amplitude and sensory gating [ 29 , 37 , 39 ], and lower MMN amplitude [ 29 , 37 , 40 – 42 ]. As regard psychopathology, the severity of negative symptoms was found to be related to increased slower rhythms in resting-state recordings and reduced N100 amplitude [ 25 , 43 , 44 ]. Conflicting findings were reported about the relationship between negative symptoms and other ERPs [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

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A multivariate approach to investigate the associations of electrophysiological indices with schizophrenia clinical and functional outcome

et al. 2023

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Background Different electrophysiological (EEG) indices have been investigated as possible biomarkers of schizophrenia. However, these indices have a very limited use in clinical practice, as their associations with clinical and functional outcomes remain unclear. This study aimed to investigate the associations of multiple EEG markers with clinical variables and functional outcomes in subjects with schizophrenia (SCZs). Methods Resting-state EEGs (frequency bands and microstates) and auditory event-related potentials (MMN-P3a and N100-P3b) were recorded in 113 SCZs and 57 healthy controls (HCs) at baseline. Illness- and functioning-related variables were assessed both at baseline and at 4-year follow-up in 61 SCZs. We generated a machine-learning classifier for each EEG parameter (frequency bands, microstates, N100-P300 task, and MMN-P3a task) to identify potential markers discriminating SCZs from HCs, and a global classifier. Associations of the classifiers’ decision scores with illness- and functioning-related variables at baseline and follow-up were then investigated. Results The global classifier discriminated SCZs from HCs with an accuracy of 75.4% and its decision scores significantly correlated with negative symptoms, depression, neurocognition, and real-life functioning at 4-year follow-up. Conclusions These results suggest that a combination of multiple EEG alterations is associated with poor functional outcomes and its clinical and cognitive determinants in SCZs. These findings need replication, possibly looking at different illness stages in order to implement EEG as a possible tool for the prediction of poor functional outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A multivariate approach to investigate the associations of electrophysiological indices with schizophrenia clinical and functional outcome

et al. 2023

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“…In particular, the MAP domain is associated with deficits in different aspects of motivation [ 1 – 4 , 6 , 10 , 33 – 35 , 40 – 42 ], or general impairment in decision making and executive control of behavior, although this latter hypothesis needs further investigations [ 28 ]. The EXP domain, on the other hand, is associated with impairments in cognition and social cognition and might be subtended by a diffuse neurodevelopmental alteration in brain connectivity leading to deficits in overall cognition [ 1 – 4 , 6 , 10 , 30 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

“…The two-factor solution of negative symptoms has been very influential over time, guiding the way research studies have been conducted to investigate the pathophysiological mechanisms of negative symptoms [ 30 ], the way rating scales are scored in statistical analyses, and the way clinical trials have been designed to develop treatments for these symptoms.…”

Section: Introductionmentioning

confidence: 99%

External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning

Giordano,

Sanmarchi,

Mucci

et al. 2023

Eur. Psychiatr.

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Background. The conceptualization of negative symptoms (NS) in schizophrenia is still controversial. Recent confirmatory factor-analytic studies suggested that the bi-dimensional model (motivational deficit [MAP] and expressive deficit [EXP]) may not capture the complexity of NS structure, which could be better defined by a five-factor (five NS domains) or a hierarchical model (five NS domains as first-order factors, and MAP and EXP, as second-order factors). A validation of these models is needed to define the structure of NS. To evaluate the validity and temporal stability of the five-factor or the hierarchical structure of the brief negative symptom scale (BNSS) in individuals with schizophrenia (SCZ), exploring associations between these models with cognition, social cognition, functional capacity, and functioning at baseline and at 4 years follow-up. Methods. Clinical variables were assessed using state-of-the-art tools in 612 SCZ at two-time points. The validity of the five-factor and the hierarchical models was analyzed through structural equation models.Results. The two models had both a good fit and showed a similar pattern of associations with external validators at the two-time points, with minor variations. The five-factor solution had a slightly better fit. The associations with external validators favored the five-factor structure. Conclusions. Our findings suggest that both five-factor and hierarchical models provide a valid conceptualization of NS in relation to external variables and that five-factor solution provides the best balance between parsimony and granularity to summarize the BNSS structure. This finding has important implications for the study of pathophysiological mechanisms and the development of new treatments.

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Electrophysiological Correlates of Reward Anticipation in Subjects with Schizophrenia: An ERP Microstate Study

et al. 2023

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The current study aimed to investigate alterations of event-related potentials (ERPs) microstate during reward anticipation in subjects with schizophrenia (SCZ), and their association with hedonic experience and negative symptoms. EEG data were recorded in thirty SCZ and twenty-three healthy controls (HC) during the monetary incentive delay task in which reward, loss and neutral cues were presented. Microstate analysis and standardized low-resolution electromagnetic tomography (sLORETA) were applied to EEG data. Furthermore, analyses correlating a topographic index (the ERPs score), calculated to quantify brain activation in relationship to the microstate maps, and scales assessing hedonic experience and negative symptoms were performed. Alterations in the first (125.0–187.5 ms) and second (261.7–414.1 ms) anticipatory cue-related microstate classes were observed. In SCZ, reward cues were associated to shorter duration and earlier offset of the first microstate class as compared to the neutral condition. In the second microstate class, the area under the curve was smaller for both reward and loss anticipation cues in SCZ as compared to HC. Furthermore, significant correlations between ERPs scores and the anticipation of pleasure scores were detected, while no significant association was found with negative symptoms. sLORETA analysis showed that hypo-activation of the cingulate cortex, insula, orbitofrontal and parietal cortex was detected in SCZ as compared to HC. Abnormalities in ERPs could be traced already during the early stages of reward processing and were associated with the anticipation of pleasure, suggesting that these dysfunctions might impair effective evaluation of incoming pleasant experiences. Negative symptoms and anhedonia are partially independent results.

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Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia: An ERP Study

Cited by 12 publications

References 106 publications

A multivariate approach to investigate the associations of electrophysiological indices with schizophrenia clinical and functional outcome

A multivariate approach to investigate the associations of electrophysiological indices with schizophrenia clinical and functional outcome

External validation of the five domains of negative symptoms: Focus on cognition, functional capacity, and real-world functioning

Electrophysiological Correlates of Reward Anticipation in Subjects with Schizophrenia: An ERP Microstate Study

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