The extensive use of fireworks generates large amounts of pollutants, deteriorating air quality and potentially causing adverse health impacts. In Medellín and its metropolitan area, although fireworks are banned during December, their use is widespread during the Christmas season, particularly during the midnight of November 30 (La Alborada) and New Year’s Eve (NYE). It is therefore essential to assess the effects of these celebrations on air quality in the region. Air-quality data from the official monitoring network and a low-cost particulate matter (PM) citizen science project, backscattering intensity (BI) retrievals from a ceilometer network, potential temperature from a microwave radiometer, and information from a radar wind profiler provide an excellent platform to study the spatio-temporal distribution of contaminants resulting from the La Alborada and NYE celebrations. Substantial increases in PM2.5 and PM10 mass concentrations due to La Alborada and NYE, ranging in some cases from 50 to 100 μgm−3, are observed in the Aburrá Valley and particularly in the densely populated communes of Medellín, with most concentration changes corresponding to ultrafine and fine particles. The PM increments resulting from fireworks show almost no increase in the net amount of black carbon in the atmosphere. Ceilometer BI profiles show a substantial change immediately after the La Alborada and NYE midnights, confined to the atmospheric boundary layer (ABL). Strong thermal inversions lead to fairly homogeneous increments in BI within the ABL, lasting until the onset of the convective boundary layer. In contrast, weak thermal inversions lead to rapid dispersion of aerosols, allowing them to episodically escape above the ABL.