Tracking Brain Development From Neonates to the Elderly by Hemoglobin Phase Measurement Using Functional Near-Infrared Spectroscopy

Liang, Zhenhu; Tian, Hao; Yang, Ho-Ching; Arimitsu, Takeshi; Takahashi, Tsuyoshi; Sassaroli, Angelo; Fantini, Sergio; Niu, Haijing; Minagawa, Yasuyo; Tong, Yunjie

doi:10.1109/jbhi.2021.3053900

Cited by 15 publications

(7 citation statements)

References 47 publications

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“…As for the analysis of oxy-Hb within a particular frequency range, a recent study reported the robustness of total-Hb measures. 90 Since infants’ hemodynamic physiology remains unclear in terms of the relationship between oxy- and deoxy-Hb and young or premature infants tend to show reversed Hemodynamic Response Function (HRF) 78 , 79 and differences in hemoglobin phase, 91 we do not have much evidence of what total-Hb measure reflects for functional brain networks. Consequently, in this study, our discussion is limited to the results of the conservative analysis.…”

Section: Discussionmentioning

confidence: 90%

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

et al. 2022

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Background Among preterm infants, higher morbidities of neurological disturbances and developmental delays are critical issues. Resting-state networks (RSNs) in the brain are suitable measures for assessing higher-level neurocognition. Since investigating task-related brain activity is difficult in neonates, assessment of RSNs provides invaluable insight into their neurocognitive development. Methods The participants, 32 term and 71 preterm neonates, were divided into three groups based on gestational age (GA) at birth. Cerebral hemodynamic activity of RSNs was measured using functional near-infrared spectroscopy in the temporal, frontal, and parietal regions. Results High-GA preterm infants (GA ≥ 30 weeks) had a significantly stronger RSN than low-GA preterm infants and term infants. Regression analyses of RSNs as a function of postnatal age (PNA) revealed a steeper regression line in the high-GA preterm and term infants than in the low-GA infants, particularly for inter-area brain connectivity between the frontal and left temporal areas. Conclusions Slower PNA-dependent development of the frontal–temporal network found only in the low-GA group suggests that significant brain growth optimal in the intrauterine environment takes place before 30 weeks of gestation. The present study suggests a likely reason for the high incidence of neurodevelopmental impairment in early preterm infants. Impact Resting-state fNIRS measurements in three neonate groups differing in gestational age (GA) showed stronger networks in the high-GA preterm infants than in the term and low-GA infants, which was partly explained by postnatal age (PNA). Regression analyses revealed a similar PNA-dependence in the development of the inter-area networks in the frontal and temporal lobes in the high-GA and term infants, and significantly slower development in the low-GA infants. These results suggest that optimal intrauterine brain growth takes place before 30 weeks of gestation. This explains one of the reasons for the high incidence of neurodevelopmental impairment in early preterm infants.

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Section: Discussionmentioning

confidence: 90%

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

et al. 2022

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“…Additionally, brain hemodynamic responses acquired by fNIRS not only exhibit apparent differences between stressful tasks and rest states but also facilitate stress detection and diagnosis [ 13 , 14 , 15 ]. By taking advantage of these characteristics, the stress level can be easily quantified by the concentration changes of oxygenated hemoglobin (ΔHbO), reduced oxygenated hemoglobin (ΔHbR), and total hemoglobin (ΔHbT) from hemodynamic oscillations [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Subdividing Stress Groups into Eustress and Distress Groups Using Laterality Index Calculated from Brain Hemodynamic Response

2022

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A stress group should be subdivided into eustress (low-stress) and distress (high-stress) groups to better evaluate personal cognitive abilities and mental/physical health. However, it is challenging because of the inconsistent pattern in brain activation. We aimed to ascertain the necessity of subdividing the stress groups. The stress group was screened by salivary alpha-amylase (sAA) and then, the brain’s hemodynamic reactions were measured by functional near-infrared spectroscopy (fNIRS) based on the near-infrared biosensor. We compared the two stress subgroups categorized by sAA using a newly designed emotional stimulus-response paradigm with an international affective picture system (IAPS) to enhance hemodynamic signals induced by the target effect. We calculated the laterality index for stress (LIS) from the measured signals to identify the dominantly activated cortex in both the subgroups. Both the stress groups exhibited brain activity in the right frontal cortex. Specifically, the eustress group exhibited the largest brain activity, whereas the distress group exhibited recessive brain activity, regardless of positive or negative stimuli. LIS values were larger in the order of the eustress, control, and distress groups; this indicates that the stress group can be divided into eustress and distress groups. We built a foundation for subdividing stress groups into eustress and distress groups using fNIRS.

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“…We started data pre-processing with a manual visual check on signal quality following previous work by Liang et al (2021). The spectrograms of all channels were plotted and the NIRS channels without a clear, visible cardiac component (∼1Hz) or only with random noise were regarded as low quality.…”

Section: Fnirs Data Preprocessingmentioning

confidence: 99%

Abnormal brain activation patterns during speech perception and production in children and adults with reading disability

CAO,

FU,

YAN

et al. 2024

Preprint

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Reading disability (RD) is associated with phonological deficits; however, it remains unknown how the phonological deficits change with age as reflected in foreign speech perception and production. In the current study, we compared brain activation during Spanish speech perception and production in native Chinese children and adults with or without RD using fNIRS. Our findings revealed greater similarity to a native Spanish speaker in vowels’ frequency formants in typical controls than in individuals with RD, and in children than in adults. In the brain, we found reduced developmental differences in the right inferior frontal gyrus (IFG) and dorsolateral prefrontal cortex (DLPFC) in individuals with RD than in controls during Spanish speech perception, suggesting slowed development in these regions. Furthermore, using multivariate pattern analysis (MVPA), we found that activation patterns in the left MTG, premotor, supplementary motor area (SMA), and IFG could serve as reliable markers of RD. We provide behavioral and neurological evidence for the developmental differences in impaired speech perception and production in RD readers which can serve as markers of RD.

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Tracking Brain Development From Neonates to the Elderly by Hemoglobin Phase Measurement Using Functional Near-Infrared Spectroscopy

Cited by 15 publications

References 47 publications

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

Subdividing Stress Groups into Eustress and Distress Groups Using Laterality Index Calculated from Brain Hemodynamic Response

Abnormal brain activation patterns during speech perception and production in children and adults with reading disability

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