2020
DOI: 10.1016/j.cell.2020.06.043
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Abstract: Highlights d A SARS-CoV-2 variant with Spike G614 has replaced D614 as the dominant pandemic form d The consistent increase of G614 at regional levels may indicate a fitness advantage d G614 is associated with lower RT PCR Cts, suggestive of higher viral loads in patients d The G614 variant grows to higher titers as pseudotyped virions

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Cited by 3,976 publications
(5,334 citation statements)
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“…D614G change is caused by an A/G nucleotide mutation at position 23,403 in the reference strain 32 , this variant is being associated with higher viral loads and enhances viral effectivity in patients 8,32,33 despite the higher viral loads, G614 is neutralizing similarly as D614 by polyclonal antibody 32 . To date, this variant becomes the dominant form displacing the WT, according to the levels of mutation in the world, presented on the nextstrain database (www.nextstrain.org).…”
Section: Resultsmentioning
confidence: 99%
“…D614G change is caused by an A/G nucleotide mutation at position 23,403 in the reference strain 32 , this variant is being associated with higher viral loads and enhances viral effectivity in patients 8,32,33 despite the higher viral loads, G614 is neutralizing similarly as D614 by polyclonal antibody 32 . To date, this variant becomes the dominant form displacing the WT, according to the levels of mutation in the world, presented on the nextstrain database (www.nextstrain.org).…”
Section: Resultsmentioning
confidence: 99%
“…A previous study revealed the global transition of the SARS-CoV-2 spike protein from the original D614 to the G614 variant. 67 To be speci c, through March 1, 2020, the G614 variant was rare outside Europe; however, it increased in frequency worldwide by the end of March. 67 As the virus types and genetic mutations were different regionally and chronologically, [65][66][67] the in uence of SARS-CoV-2 on the olfactory epithelium may have differed according to virus type and genetic mutation.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, a high similarity was observed in tested strains collected at the early stage of COVID-19 outbreak when compared with reference strain (NC_045512). However, numerous novel mutations, such as S-D614G, were identi ed in current strains worldwide according to recent studies [21]. The increased genetic diversity of SARS-CoV-2 in human hosts over time cannot be neglected.…”
Section: Discussionmentioning
confidence: 99%