Sediments of Lake Lubińskie were investigated to track human-induced vegetation and fire activity changes in Lubusz Land (western Poland). Geochemical data, as well as pollen, macrocharcoal, and statistical analyses (CONISS, CharAnalysis, PCA, BINCOR) allowed us to recognize the major phases of the human impact. At the beginning of the investigation period, 3000 years ago, the area had already experienced disturbances from humans caused by the Lusatian and Przeworsk cultures, followed by western Slavs, and modern society. Land cover changes were mostly related to deforestation and gaining arable lands. The forest communities shrank substantially also due to timber demand from the growing society. However, the pollen record shows that within the last ~50 years the area experienced forest regeneration. Wildfires played an important role in shaping the landscape in the area of Lake Lubińskie. Overall, 23 fires were identified within the profile showing relatively high fire frequencies (up to 4.8 fires per 500 years) between 600 −38/+36 BCE and 1 ± 206 CE as well as between 1065 ± 98 CE and 1380 ± 92 CE. The highest fire frequency was observed between the 1000s and mid-1400s, showing decreased fire return interval (FRI) and increased charcoal flux as well as progressive deforestation. These changes were related to the establishment of villages (e.g., Lubin village) and the presence of the Joannites. Fire was most commonly used as a land management tool to gain patches of land for agrarian purposes. PCA and BINOCR analyses suggest that most of the fires were set by humans, but natural causes of ignition cannot be excluded. The land-use changes affected the vegetation in the region, causing increased erosion and shifts in the geochemistry of the lake reflected in better bottom waters ventilation and progressive eutrophication.