Context.-The mechanics of the practice of medicine in general and of pathology in particular is evolving rapidly with the rise in the use of electronic information systems for managing the care of individual patients, including the ordering and reporting of laboratory tests, maintaining the health of served populations, and documenting the full range of health care activities. Pathologists currently in practice and those in training need to acquire additional skills in informatics to be prepared to maintain a central role in patient care.Objective.-To summarize the evolving landscape of pathology informatics, with particular attention to the preparation of pathologists for this discipline and to the possible influence of the new subspecialty certification in clinical informatics.Data Sources.-Most of the information discussed is drawn from the authors' direct experience with informatics, resident and fellow education, and the organizations supporting these activities in pathology.Conclusions.-The increasing reliance of medical practice on electronic health records and other clinical information systems is creating a greater need for physicians skilled in the use and management of these tools. The establishment of clinical informatics as a formal subspecialty in medicine will likely help secure a role for physicians within information management structures at health care institutions. Pathologists must actively engage in informatics to assure that our specialty is appropriately recognized and represented in this growing discipline.(Arch Pathol Lab Med. 2014;138:505-511; doi: 10.5858/ arpa.2013-0328-RA) I nformatics is a term that means different things to different people. While most will accept the generic definition of ''the science of information management,'' how that definition manifests itself in different clinical settings varies significantly.1 The term pathology informatics has existed for decades, but the recent surge in implementation of electronic health record (EHR) systems and an expanding role of pathology laboratory information systems (LISs) in orchestrating the day-to-day activities in a pathology laboratory and in integrating with hospital systems has turned a new focus to this subspecialty area of pathology. With the increasing penetration of high-throughput data generating techniques such as next-generation sequencing and personalized medicine, both pathologists in practice and pathologists in training are beginning to realize that informatics is something they can no longer ignore.Even academic medical centers are changing their attitudes toward informatics. While only a decade ago, many academic centers considered informatics to be a technical activity not meeting the scholarship requirements for academic promotion, now contributions to clinical information management activities are increasingly recognized as both scholarly and crucial to the future of health care. In fact, many institutions have chief medical information officers to manage the rapidly changing electronic environment. Large...