Tracking of brachial and central aortic systolic pressure over the normal human lifespan: insight from the arterial pulse waveforms

Adji, Audrey; O’Rourke, Michael

doi:10.1111/imj.14815

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…[ 76 ] In this regard, depending on the desired final application, a medical adhesive must withstand pressure values equivalent to normal arterial blood pressure (<120 mmHg). [ 77 ] TA|PUL‐MA 13% adhesive was tested ex vivo regarding its ability to avoid air leakage, using a porcine skin model. The adhesive capacity of the material allowed it to withstand a pressure of 150 mmHg (Movie S8, Supporting Information), greater than normal blood pressure.…”

Section: Resultsmentioning

confidence: 99%

Natural Polymer‐Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On‐Demand Detachment

Sacramento,

Oliveira,

Gomes

et al. 2024

Adv Healthcare Materials

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Medical adhesives are arising as an important clinical tool as adjuvants for sutures and staples in wound closure and healing, and in the achievement of hemostasis. However, clinical adhesives combining cytocompatibility, as well as strong and stable adhesion in physiological conditions are still in demand. Herein, a mussel‐inspired strategy is explored to produce adhesive coacervates using tannic acid (TA) and methacrylate pullulan (PUL‐MA). TA|PUL‐MA coacervates mainly comprise van der Waals forces and hydrophobic interactions. The methacrylic groups in PUL backbone increase the number of interactions in the adhesives matrix, resulting in enhanced cohesion and adhesion strength (72.7 Jm−2), comparing to the non‐methacrylated coacervate. The adhesive properties were kept in physiologic‐mimetic solutions (72.8 Jm−2) for 72 h. The photopolymerization of TA|PUL‐MA enabled the on‐demand detachment of the adhesive. The poor cytocompatibility associated with the use of phenolic groups was here circumvented by mixing reactive oxygen species (ROS)‐degrading enzyme in the adhesive coacervate. This addition did not hamper the adhesive character of the materials, neither their anti‐microbial nor hemostatic properties. This affordable and straightforward methodology, together with the tailorable adhesivity even in wet environments, high cytocompatibility and anti‐bacterial activity, enable foreseeing TA|PUL‐MA as a promising ready‐to‐use bioadhesive for biomedical applications.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Natural Polymer‐Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On‐Demand Detachment

Sacramento,

Oliveira,

Gomes

et al. 2024

Adv Healthcare Materials

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show abstract

“…The aortic pressure wave changes more than the flow wave with ageing [5,[30][31][32]. In normal healthy patients, the ascending aortic flow wave is nearly triangular through adult life.…”

Section: Age and Valvular-related Changes To The Aortic Pressure Waveformmentioning

confidence: 99%

Ageing, Hypertension and Aortic Valve Stenosis: A Conscious Uncoupling

Hungerford

Adji

Hayward

et al. 2021

Heart, Lung and Circulation

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Aortic valve stenosis (AS) is no longer considered to be a disease of fixed left ventricular (LV) afterload (due to an obstructive valve), but rather, functions as a series circuit with important contributions from both the valve and ageing vasculature. Patients with AS are frequently elderly, with hypertension and a markedly remodelled aorta. The arterial component is sizable, and yet, the contribution of ventricular afterload has been difficult to determine. Arterial stiffening increases the speed of propagation of the blood pressure wave along the central arteries (estimated as the pulse wave velocity), which results in an earlier return of reflected waves. The effect is to augment blood pressure in the proximal aorta during systole, increasing the central pulse pressure and, in turn, placing even greater afterload on the heart. Elevated global LV afterload is known to have adverse consequences on LV remodelling, function and survival in patients with AS. Consequently, there is renewed focus on methods to estimate the relative contributions of local versus global changes in arterial mechanics and valvular haemodynamics in patients with AS. We present a review on existing and upcoming methods to quantify valvulo-arterial impedance and thereby global LV load in patients with AS.

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Ageing, hypertension and aortic valve stenosis – Understanding the series circuit using cardiac magnetic resonance and applanation tonometry

Hungerford

Adji

Bart

et al. 2021

International Journal of Cardiology Hypertension

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Tracking of brachial and central aortic systolic pressure over the normal human lifespan: insight from the arterial pulse waveforms

Cited by 4 publications

References 41 publications

Natural Polymer‐Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On‐Demand Detachment

Natural Polymer‐Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On‐Demand Detachment

Ageing, Hypertension and Aortic Valve Stenosis: A Conscious Uncoupling

Ageing, hypertension and aortic valve stenosis – Understanding the series circuit using cardiac magnetic resonance and applanation tonometry

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