Tracking of Ubiquitin Signaling through 3.5 Billion Years of Combinatorial Conjugation
Alena N. Kaminskaya,
Alena S. Evpak,
Alexey A. Belogurov
et al.
Abstract:Ubiquitination is an evolutionary, ancient system of post-translational modification of proteins that occurs through a cascade involving ubiquitin activation, transfer, and conjugation. The maturation of this system has followed two main pathways. The first is the conservation of a universal structural fold of ubiquitin and ubiquitin-like proteins, which are present in both Archaea and Bacteria, as well as in multicellular Eukaryotes. The second is the rise of the complexity of the superfamily of ligases, whic… Show more
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