1997
DOI: 10.1007/s000180050060
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Tracking prions: the neurografting approach

Abstract: The physical nature of the agent that causes transmissible spongiform encephalopathies (the 'prion'), is the subject of passionate controversy. Investigation of it has benefited tremendously from the use of transgenic and knockout technologies. However, prion diseases present several other enigmas, including the mechanism of brain damage and how the affinity of the agent for the central nervous system is controlled. Here we show that such questions can be effectively addressed in transgenic and knockout system… Show more

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Cited by 6 publications
(2 citation statements)
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“…Neuroectodermal grafting procedure. Transplantation of neural tissue in mice was performed essentially as described (1,3,16,18). Briefly, tga20 transgenic mice overexpressing PrP C were mated, and the morning at which a plug was detected was defined as E0.5.…”
Section: Methodsmentioning
confidence: 99%
“…Neuroectodermal grafting procedure. Transplantation of neural tissue in mice was performed essentially as described (1,3,16,18). Briefly, tga20 transgenic mice overexpressing PrP C were mated, and the morning at which a plug was detected was defined as E0.5.…”
Section: Methodsmentioning
confidence: 99%
“…12 In experiments that might mimic natural tissue chimerism, prions have been shown to replicate within genetically susceptible cells engrafted in tissues otherwise composed of scrapie-resistant cells. 1,2,8 Application of methodology to detect genetically susceptible cells in an environment of resistant cells could help determine if natural tissue chimerism might similarly support prion replication in sheep.…”
Section: Discussionmentioning
confidence: 99%