Tracking the origin, development, and differentiation of hematopoietic stem cells

Dharampuriya, Priyanka R.; Scapin, Giorgia; Wong, Colline; Wagner, Katherine; Cillis, Jennifer L.; Shah, Dhvanit I.

doi:10.1016/j.ceb.2018.01.002

Cited by 22 publications

(7 citation statements)

References 74 publications

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“…Our study found the same outcomes in IgAN. As we all know, platelets and lymphocytes are derived from the same hematopoietic stem cells and the PLR should be kept constant for homeostasis [ 28 , 29 ]. Higher PLR condition means relatively high platelets and low lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

et al. 2020

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Purpose Platelet-to-lymphocyte ratio (PLR) was established showing the poor prognosis in several diseases, such as malignancies and cardiovascular diseases. But limited study has been conducted about the prognostic value of PLR on the long-term renal survival of patients with Immunoglobulin A nephropathy (IgAN). Methods We performed an observational cohort study enrolling patients with biopsy-proven IgAN recorded from November 2011 to March 2016. The definition of composite endpoint was eGFR decrease by 50%, eGFR < 15 mL/min/1.73 m2, initiation of dialysis, or renal transplantation. Patients were categorized by the magnitude of PLR tertiles into three groups. The Kaplan–Meier curves and multivariate Cox models were performed to determine the association of PLR with the renal survival of IgAN patients. Results 330 patients with a median age of 34.0 years were followed for a median of 47.4 months, and 27 patients (8.2%) had reached the composite endpoints. There were no differences among the three groups (PLR < 106, 106 ≤ PLR ≤ 137, and PLR > 137) in demographic characteristics, mean arterial pressure (MAP), proteinuria, and estimated glomerular filtration rate (eGFR) at baseline. The Kaplan–Meier curves showed that the PLR > 137 group was significantly more likely to poor renal outcomes than the other two groups. Using univariate and multivariate cox regression analyses, we found that PLR > 137 was an independent prognostic factor for poor renal survival in patients with IgAN. Subgroup analysis revealed that the PLR remained the prognostic value for female patients or patients with eGFR less than 60 mL/min/1.73 m2. Conclusions Our results underscored that baseline PLR was an independent prognostic factor for poor renal survival in patients with IgAN, especially for female patients or those patients with baseline eGFR less than 60 mL/min/1.73 m2.

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Section: Discussionmentioning

confidence: 99%

The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

et al. 2020

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“…For hematopoiesis, HSCs are generated in different organs, including the aorta-gonad-mesonephros (AGM), fetal liver and bone marrow. HSCs at each developmental stage exhibit distinctive functional characteristics with respect to the cell cycle, response to cytokines, proliferation potential, and long-term hematopoietic function 32,52–54 . Accordingly, many hematopoietic functions, including myeloid and immune functions, become distinct across the fetal, neonatal and adult stages, which in turn become differentially vulnerable to hematological disorders such as bone marrow failure or hematological malignancies 53–56 .…”

Section: Discussionmentioning

confidence: 99%

Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells

Lee

Jeong

Lee

et al. 2019

Sci Rep

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The bone marrow (BM) microenvironment serves as a stem cell niche regulating the in vivo cell fate of normal hematopoietic stem cells (HSC) as well as leukemia stem cells (LSCs). Accumulating studies have indicated that the regeneration of normal HSCs and the process of leukemogenesis change with advancing age. However, the role of microenvironmental factors in these age-related effects are unclear. Here, we compared the stem cell niche in neonatal and adult BM to investigate potential differences in their microenvironmental regulation of both normal and leukemic stem cells. We found that the mesenchymal niche in neonatal BM, compared to adult BM, was characterized by a higher frequency of primitive subsets of mesenchymal stroma expressing both platelet-derived growth factor receptor and Sca-1, and higher expression levels of the niche cross-talk molecules, Jagged-1 and CXCL-12. Accordingly, normal HSCs transplanted into neonatal mice exhibited higher levels of regeneration in BM, with no difference in homing efficiency or splenic engraftment compared to adult BM. In contrast, in vivo self-renewal of LSCs was higher in adult BM than in neonatal BM, with increased frequencies of leukemia-initiating cells as well as higher lympho-myeloid differentiation potential towards biphenotypic leukemic cells. These differences in LSC self-renewal capacity between neonates and adults was abrogated by switching of recipients, confirming their microenvironmental origin. Our study provides insight into the differences in leukemic diseases observed in childhood and adults, and is important for interpretation of many transplantation studies involving neonatal animal models.

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“…As the focus of this review is the role of sphingolipids in hematopoiesis, herein we have presented only a very simplified view of how hematopoiesis is currently understood; this is intended as a guide for the analysis summarized in the later sections. For an in-depth discussion of the processes that govern hematopoiesis, the reader is referred to the following excellent reviews [4,11,[13][14][15][16]].…”

Section: Introduction 1hematopoietic Lineage Commitmentmentioning

confidence: 99%

Sphingolipids in Hematopoiesis: Exploring Their Role in Lineage Commitment

Raza

Salman

Luberto

2021

Cells

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Sphingolipids, associated enzymes, and the sphingolipid pathway are implicated in complex, multifaceted roles impacting several cell functions, such as cellular homeostasis, apoptosis, cell differentiation, and more through intrinsic and autocrine/paracrine mechanisms. Given this broad range of functions, it comes as no surprise that a large body of evidence points to important functions of sphingolipids in hematopoiesis. As the understanding of the processes that regulate hematopoiesis and of the specific characteristics that define each type of hematopoietic cells is being continuously refined, the understanding of the roles of sphingolipid metabolism in hematopoietic lineage commitment is also evolving. Recent findings indicate that sphingolipid alterations can modulate lineage commitment from stem cells all the way to megakaryocytic, erythroid, myeloid, and lymphoid cells. For instance, recent evidence points to the ability of de novo sphingolipids to regulate the stemness of hematopoietic stem cells while a substantial body of literature implicates various sphingolipids in specialized terminal differentiation, such as thrombopoiesis. This review provides a comprehensive discussion focused on the mechanisms that link sphingolipids to the commitment of hematopoietic cells to the different lineages, also highlighting yet to be resolved questions.

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Tracking the origin, development, and differentiation of hematopoietic stem cells

Cited by 22 publications

References 74 publications

The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells

Sphingolipids in Hematopoiesis: Exploring Their Role in Lineage Commitment

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