Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia

Li, Qian; Zhai, Liying; Jiang, Qinying; Qin, Wen; Li, Qingji; Yin, Xiaohui; Guo, Mingxia

doi:10.1016/j.neulet.2015.04.027

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…The approach to an asymptotic value around 8–9 years is consistent with these and other results (e.g. Braunitzer et al, 2012; see also review by Hadad et al, 2015). However, despite the different age functions, global form and motion thresholds had a substantial shared variance: when the effect of age was removed by analysing the studentized residuals for each threshold in a regression against age and gender, individual form and motion thresholds showed a correlation of r = 0.597.…”

Section: Resultssupporting

confidence: 91%

“…Fractional anisotropy in the superior longitudinal fasciculus is also reduced compared to controls in several neurodevelopmental disorders, including cerebral palsy, where it is correlated with IQ (Ballester-Plané et al , 2016) and amblyopia, where it is correlated with visual acuity (Li et al, 2015). It is also correlated with response time variability in attention-deficit hyperactivity disorder (Wolfers et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Individual differences in children’s global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus

et al. 2017

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Reduced global motion sensitivity, relative to global static form sensitivity, has been found in children with many neurodevelopmental disorders, leading to the “dorsal stream vulnerability” hypothesis (Braddick et al, Neuropsychologia, 2003). Individual differences in typically developing children’s global motion thresholds have been shown to be associated with variations in specific parietal cortical areas (Braddick et al, J Cog Neuro, 2016). Here, in 125 children aged 5–12 years, we relate individual differences in global motion and form coherence thresholds to fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF), a major fiber tract communicating between parietal lobe and anterior cortical areas. We find a positive correlation between FA of the right SLF and individual children’s sensitivity to global motion coherence, while FA of the left SLF shows a negative correlation. Further analysis of parietal cortical area data shows that this is also asymmetrical, showing a stronger association with global motion sensitivity in the left hemisphere. None of these associations hold for an analogous measure of global form sensitivity. We conclude that a complex pattern of structural asymmetry, including the parietal lobe and the superior longitudinal fasciculus, is specifically linked to the development of sensitivity to global visual motion. This pattern suggests that individual differences in motion sensitivity are primarily linked to parietal brain areas interacting with frontal systems in making decisions on integrated motion signals, rather than in the extra-striate visual areas that perform the initial integration. The basis of motion processing deficits in neurodevelopmental disorders may depend on these same structures.

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Individual differences in children’s global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus

et al. 2017

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“…Considering the role the optic radiations play in relaying information from the subcortical LGN to V1, the preservation of this key visual system tract could contribute to the intact visual processing previously demonstrated in ME participants [Kelly et al, ; Steeves et al, ]. For example, lower FA in the optic radiations of children with amblyopia has been associated with reduced visual acuity [Li et al, ]. Thus, it is possible that the less extensive changes to the optic radiations following early monocular enucleation may be associated with the fact that ME participants demonstrate equivalent acuity compared to binocular viewing controls [Reed et al, ]…”

Section: Discussionmentioning

confidence: 99%

Altered white matter structure in the visual system following early monocular enucleation

Wong

Rafique

Kelly

et al. 2017

Human Brain Mapping

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Partial visual deprivation from early monocular enucleation (the surgical removal of one eye within the first few years of life) results in a number of long-term morphological adaptations in adult cortical and subcortical visual, auditory, and multisensory brain regions. In this study, we investigated whether early monocular enucleation also results in the altered development of white matter structure. Diffusion tensor imaging and probabilistic tractography were performed to assess potential differences in visual system white matter in adult participants who had undergone early monocular enucleation compared to binocularly intact controls. To examine the microstructural properties of these tracts, mean diffusion parameters including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were extracted bilaterally. Asymmetries opposite to those observed in controls were found for FA, MD, and RD in the optic radiations, the projections from primary visual cortex (V1) to the lateral geniculate nucleus (LGN), and the interhemispheric V1 projections of early monocular enucleation participants. Early monocular enucleation was also associated with significantly lower FA bidirectionally in the interhemispheric V1 projections. These differences were consistently greater for the tracts contralateral to the enucleated eye, and are consistent with the asymmetric LGN volumes and optic tract diameters previously demonstrated in this group of participants. Overall, these results indicate that early monocular enucleation has long-term effects on white matter structure in the visual pathway that results in reduced fiber organization in tracts contralateral to the enucleated eye. Hum Brain Mapp 39:133-144, 2018.V C 2017 Wiley Periodicals, Inc.

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“…Moreover, eye growth is parellel to neurodevelopment. White matter changes were found in children with anisometropic amblyopia [42]. It has also been reported that low 5-minute Apgar score increased the risk of reduced vision in children [43].…”

Section: Discussionmentioning

confidence: 78%

The biometric parameters of aniso-astigmatism and its risk factor in Chinese preschool children: the Nanjing Eye Study

Tong

Hao

Wang

et al. 2020

Preprint

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BackgroundsTo determine the biometric components of aniso-astigmatism and associated maternal risk factors in Chinese preschool children.MethodsIn the population-based, cohort Nanjing Eye Study, children were measured for noncycloplegic refractive error using an autorefractor and for biometric parameters using an optical low-coherent reflectometry. The difference of total astigmatism (TA) between both eyes was calculated using cylinder power (non-vectorial aniso-TA was defined as ≥ 1.00 Dioptre Cylinder [DC] between both eyes) and by vector analysis (vectorial aniso-TA was defined as a difference of ≥ 0.5 in J0 or J45 between both eyes which is equivalent to 1.00 DC). The prevalence of aniso-TA was presented. Interocular biometric parameters were compared between with vs. without aniso-astigmatism group. In addition, risk factors were determined using multivariate logistic regression model.ResultsOf 1131 children (66.90 ± 3.38 months, 53.31% male), the prevalence of non-vectorial aniso-TA was 1.95% (95% Confidence Interval (CI) = 1.14%-2.75%), while the prevalence of vectorial aniso-TA was twice as common as non-vectorial aniso-TA, neither varying with sex or age. With aniso-TA eyes were more asymmetric in axial length and corneal curvature radius than without aniso-TA eyes. In multivariate logistic regression model, 5-min apgar score less than 7 was significantly associated with higher risk of aniso-TA (vectorial aniso-TA: Odds Ratio (OR) = 6.42, 95%CI = 2.63–15.69, P < 0.001; non-vectorial aniso-TA: OR = 4.92, 95%CI = 1.41–17.68, P = 0.01). Being twin or triple was significantly associated with higher risk of vectorial aniso-CA (OR = 2.43, 95%CI = 1.05–5.60, P = 0.38). Pre-term delivery (OR = 2.60, 95%CI = 1.09–6.15, P = 0.03) and post-term delivery (OR = 3.61, 95%CI = 1.31–9.96, P = 0.01) were significantly associated with higher risk of vectorial aniso-CA.ConclusionsBoth corneal curvature radius and axial length asymmetry were correlated with aniso-TA. Children with 5-min apgar score < 7 were more likely to have aniso-TA, while twin or triple, pre-term or post-term delivery were risk factors for vectorial aniso-CA.

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Tract-based spatial statistics analysis of white matter changes in children with anisometropic amblyopia

Cited by 17 publications

References 34 publications

Individual differences in children’s global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus

Individual differences in children’s global motion sensitivity correlate with TBSS-based measures of the superior longitudinal fasciculus

Altered white matter structure in the visual system following early monocular enucleation

The biometric parameters of aniso-astigmatism and its risk factor in Chinese preschool children: the Nanjing Eye Study

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