Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data

Smith, Stephen M.; Jenkinson, Mark; Johansen‐Berg, Heidi; Rueckert, Daniel; Nichols, Thomas E.; Mackay, Clare E.; Watkins, Kate E.; Ciccarelli, Olga; Cader, M Z; Matthews, Paul M.; Behrens, Timothy E.J.

doi:10.1016/j.neuroimage.2006.02.024

Cited by 5,966 publications

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“…Contrary to one whole‐brain DTI study (Saini et al., 2012) but in agreement with another (Klein et al., 2011), we did not find any significant changes in the cerebellum or cerebellar peduncles using TBSS method (Smith et al., 2006). Klein et al.…”

Section: Discussionmentioning

confidence: 99%

“…TBSS (Smith et al., 2006) was chosen as an optimal full‐automated analysis tool that allows investigating the whole‐brain without selection of specific WM region beforehand. All FA images were registered into a common space using nonlinear registration with FMRIB58_FA as a registration target image (Andersson, Jenkinson, & Smith, 2007a, 2007b).…”

Section: Methodsmentioning

confidence: 99%

“…Previous DTI studies in ET confirmed an involvement of the CTC (Jia, Jia‐lin, Qin, Qing, & Yan, 2011; Klein et al., 2011; Nicoletti et al., 2010; Saini et al., 2012) but also of areas outside the “tremor network” (Klein et al., 2011; Saini et al., 2012) when a whole‐brain DTI analysis using tract‐based spatial statistics (TBSS) (Smith et al., 2006) was applied. The areas outside CTC were linked to nonmotor ET symptoms (Benito‐León et al., 2017; Bhalsing et al., 2014, 2015), which provides further evidence for the pathophysiological complexity of ET.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we utilized TBSS (Smith et al., 2006), as a method that allows exploring whole‐brain DTI metrics, to examine the relationship between WM changes and both clinical rating scales (i.e., FTM and Bain scale) and accelerometry tremor measures (i.e., amplitude, frequency and their combined score).…”

Section: Introductionmentioning

confidence: 99%

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White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

et al. 2018

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BackgroundAn evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET.ObjectivesTo investigate ET‐related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry.MethodsTract‐based spatial statistics (TBSS) approach was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age‐ and gender‐matched healthy individuals. Clinical scales, tremor frequency and amplitude as measured by accelerometry were correlated with DTI data.Results ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in nonmotor regions including the inferior fronto‐occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores.ConclusionsThe results show that ET‐related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

et al. 2018

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“…These DTI parameters were compared voxel‐by‐voxel with TBSS (Smith et al., 2006), as part of FSL. Briefly, the mean FA skeleton image that represents the center of tracts, consistent across subjects, was obtained by thinning the across‐subjects averaged FA image (threshold of 0.2).…”

Section: Methodsmentioning

confidence: 99%

Complex regional pain syndrome: The matter of white matter?

et al. 2017

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IntroductionMany central pathophysiological aspects of complex regional pain syndrome (CRPS) are still unknown. Although brain‐imaging studies are increasingly supporting the contribution of the central nervous system to the generation and maintenance of the CRPS pain, the brain's white‐matter alterations are seldom investigated.MethodsIn this study, we used diffusion tensor imaging to explore white‐matter changes in twelve CRPS‐type‐1 female patients suffering from chronic right upper‐limb pain compared with twelve healthy control subjects.ResultsTract‐based spatial‐statistics analysis revealed significantly higher mean diffusivity, axial diffusivity, and radial diffusivity in the CRPS patients, suggesting that the structural connectivity is altered in CRPS. All these measures were altered in the genu, body, and splenium of corpus callosum, as well as in the left anterior and posterior and the right superior parts of the corona radiata. Axial diffusivity was significantly correlated with clinical motor symptoms at whole‐brain level, supporting the physiological significance of the observed white‐matter abnormalities.ConclusionsAltogether, our findings further corroborate the involvement of the central nervous system in CRPS.

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Neuroimaging of Cognitive Dysfunction and Depression in Aging Retired National Football League Players

Hart¹,

Kraut

Womack³

et al. 2013

JAMA Neurol

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To assess cognitive impairment and depression in aging former professional football (National Football League [NFL]) players and to identify neuroimaging correlates of these dysfunctions. Design:We compared former NFL players with cognitive impairment and depression, cognitively normal retired players who were not depressed, and matched healthy control subjects.Setting: Research center in the North Texas region of the United States.Patients: Cross-sectional sample of former NFL players with and without a history of concussion recruited from the North Texas region and age-, education-, and IQ-matched controls. Thirty-four retired NFL players (mean age, 61.8 years) underwent neurological and neuropsychological assessment. A subset of 26 players also underwent detailed neuroimaging; imaging data in this subset were compared with imaging data acquired in 26 healthy matched controls.Main Outcome Measures: Neuropsychological measures, clinical diagnoses of depression, neuroimaging mea-sures of white matter pathology, and a measure of cerebral blood flow.Results: Of the 34 former NFL players, 20 were cognitively normal. Four were diagnosed as having a fixed cognitive deficit; 8, mild cognitive impairment; 2, dementia; and 8, depression. Of the subgroup in whom neuroimaging data were acquired, cognitively impaired participants showed the greatest deficits on tests of naming, word finding, and visual/verbal episodic memory. We found significant differences in white matter abnormalities in cognitively impaired and depressed retired players compared with their respective controls. Regional blood flow differences in the cognitively impaired group (left temporal pole, inferior parietal lobule, and superior temporal gyrus) corresponded to regions associated with impaired neurocognitive performance (problems with memory, naming, and word finding). Conclusions:Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy controls. These deficits are correlated with white matter abnormalities and changes in regional cerebral blood flow.

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Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data

Cited by 5,966 publications

References 50 publications

White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

Complex regional pain syndrome: The matter of white matter?

Neuroimaging of Cognitive Dysfunction and Depression in Aging Retired National Football League Players

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