Tractography‐based parcellation of the human left inferior parietal lobule

Wang, Jiaojian; Fan, Lingzhong; Zhang, Yu; Liu, Yong; Jiang, Di; Zhang, Yuanchao; Yu, Chunshui; Jiang, Tianzi

doi:10.1016/j.neuroimage.2012.07.045

Cited by 97 publications

(91 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no doubt that new knowledge on PFC dysconnectivity in schizophrenia will be warranted by the next generation of brain atlases, such as the Brainnetome atlas [83] , which has finer parcellation of the PFC and other brain regions [84][85][86][87] .…”

Section: Fine-grained Parcellation Of the Pfcmentioning

confidence: 99%

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

et al. 2015

Self Cite

View full text Add to dashboard Cite

Schizophrenia is hypothesized to arise from disrupted brain connectivity. This "dysconnectivity hypothesis" has generated interest in discovering whether there is anatomical and functional dysconnectivity between the prefrontal cortex (PFC) and other brain regions, and how this dysconnectivity is linked to the impaired cognitive functions and aberrant behaviors of schizophrenia. Critical advances in neuroimaging technologies, including diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), make it possible to explore these issues. DTI affords the possibility to explore anatomical connectivity in the human brain in vivo and fMRI can be used to make inferences about functional connections between brain regions. In this review, we present major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia. We then briefly discuss future prospects that need to be explored in order to move beyond simple mapping of connectivity changes to elucidate the neuronal mechanisms underlying schizophrenia.

show abstract

Section: Fine-grained Parcellation Of the Pfcmentioning

confidence: 99%

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, the AG consists of the anterior and posterior areas PGa and PGp, respectively (Caspers et al, 2006(Caspers et al, , 2008. More recently, two studies employed DWI tractography to segment right and left IPL (Mars et al, 2011;Wang et al, 2012). The right-hemispheric IPL was divided into five subregions: the most anterior cluster (red, color coded as in Fig.…”

Section: Subdivisions Of the Iplmentioning

confidence: 99%

“…The left-hemispheric IPL was divided into six subclusters: a dorsal anterior cluster (blue, color coded as in Fig. 1 of Wang et al, 2012); a ventral anterior cluster (green); and four clusters successively posterior to the green cluster: light green, yellow, orange, and red. The yellow cluster occupies the most posterior part of the SMG, and the orange and red cluster each corresponds to the anterior and posterior AG, respectively .…”

Section: Subdivisions Of the Iplmentioning

confidence: 99%

“…Studies of white matter tractography based on diffusion-weighted imaging (DWI) (Mars et al, 2011;Wang et al, 2012) and those of functional clustering based on resting-state connectivity (Doucet et al, 2011;Nelson et al, 2010;Power et al, 2011;Yeo et al, 2011) also defined subregions that did not follow the boundaries of the IPS, AG, and SMG. However, none of these studies have systematically examined how these subregions are related to the IPS, AG, and SMG, as widely ''localized'' in functional neuroimaging.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Clustering of the Human Inferior Parietal Lobule by Whole-Brain Connectivity Mapping of Resting-State Functional Magnetic Resonance Imaging Signals

Zhang

2014

Brain Connectivity

View full text Add to dashboard Cite

The human inferior parietal lobule (IPL) comprised the lateral bank of the intraparietal sulcus, angular gyrus, and supramarginal gyrus, defined on the basis of anatomical landmarks and cytoarchitectural organization of neurons. However, it is not clear as to whether the three areas represent functional subregions within the IPL. For instance, imaging studies frequently identified clusters of activities that cut across areal boundaries. Here, we used restingstate functional magnetic resonance imaging (fMRI) data to examine how individual voxels within the IPL are best clustered according to their connectivity to the whole brain. The results identified a best estimate of seven clusters that are hierarchically arranged as the anterior, middle, and posterior subregions. The anterior, middle, and posterior IPL are each significantly connected to the somatomotor areas, superior/middle/inferior frontal gyri, and regions of the default mode network. This functional segregation is supported by recent cytoarchitechtonics and tractography studies. IPL showed hemispheric differences in connectivity that accord with a predominantly left parietal role in tool use and language processing and a right parietal role in spatial attention and mathematical cognition. The functional clusters may also provide a more parsimonious and perhaps even accurate account of regional activations of the IPL during a variety of cognitive challenges, as reported in earlier fMRI studies.

show abstract

“…Cytoarchitectonic, functional, and anatomical studies suggest that the rostral aspect of aIPL represents the putative human homologue of monkey area PF (Caspers et al, 2006), with similar motor (Binkofski et al, 1999), somatosensory (Ruben et al, 2001), and social functions (Caspers, Zilles, Laird, & Eickhoff, 2010;Gazzola & Keysers, 2009;Buccino et al, 2001) as well as connectivity patterns ( Wang et al, 2012). Studies in macaque monkeys show that area PF contains neurons with somatosensory and proprioceptive responses that also discharge in association with movements, especially goal-directed motor acts Hyvärinen, 1982).…”

Section: Active Interpersonal Touch Mediated By An Objectmentioning

confidence: 99%

Reach Out and Touch Someone: Anticipatory Sensorimotor Processes of Active Interpersonal Touch

Ebisch

Ferri

Romani

et al. 2014

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

Abstract■ Anticipating the sensorimotor consequences of an action for both self and other is fundamental for action coordination when individuals socially interact. Somatosensation constitutes an elementary component of social cognition and sensorimotor prediction, but its functions in active social behavior remain unclear. We hypothesized that the somatosensory system contributes to social haptic behavior as evidenced by specific anticipatory activation patterns when touching an animate target (human hand) compared with an inanimate target (fake hand). fMRI scanning was performed during a paradigm that allowed us to isolate the anticipatory representations of active interpersonal touch while controlling for nonsocial sensorimotor processes and possible confounds because of interpersonal relationships or socioemotional valence. Active interpersonal touch was studied both as skin-to-skin contact and as object-mediated touch. The results showed weaker deactivation in primary somatosensory cortex and medial pFC and stronger activation in cerebellum for the animate target, compared with the inanimate target, when intending to touch it with oneʼs own hand. Differently, in anticipation of touching the human hand with an object, anterior inferior parietal lobule and lateral occipital-temporal cortex showed stronger activity. When actually touching a human hand with oneʼs own hand, activation was stronger in medial pFC but weaker in primary somatosensory cortex. The findings provide new insight on the contribution of simulation and sensory prediction mechanisms to active social behavior. They also suggest that literally getting in touch with someone and touching someone by using an object might be approached by an agent as functionally distinct conditions. ■

show abstract

Tractography‐based parcellation of the human left inferior parietal lobule

Cited by 97 publications

References 72 publications

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

Functional Clustering of the Human Inferior Parietal Lobule by Whole-Brain Connectivity Mapping of Resting-State Functional Magnetic Resonance Imaging Signals

Reach Out and Touch Someone: Anticipatory Sensorimotor Processes of Active Interpersonal Touch

Contact Info

Product

Resources

About