Traditional and biotechnological aspects of obtaining medicinal preparations fromRhodiola Rosea L. (A review)

Abstract

By now, there are about 300 medicinal plants successfully used in medical practice. Moreover, recent years showed a steady tendency for extending this class.Obtaining phytopreparations always involves extraction of the biologically active substances, followed by their separation and purification using various technological methods. One of the main negative factors, introducing instability in the manufacture of phytopreparations, is an irregular character of the supply of raw materials for their production. The reasons include, in particular, a sharp decrease in the natural stock of both wild-growing and cultivated medicinal plants.In connection with this, both the search for new medicinal plants and work on creation of a reliable stock of pharmacopoeial plants are of considerable practical value. Besides the traditional work on large-scale cultivation of medicinal plants, a highly promising direction is the biotechnological production of raw plant materials and related preparations.Biotechnology, which means carrying out technological processes with the aid of biological systems, has been rapidly developing in the past years and is recognized as a priority direction in the future scientific progress [ 1 -8].An important field of biotechnology is the growth of plant cells (or medicinal plant tissue cultures), in which the main difficulties are related to development of the necessary commercial equipment. This field is most extensively developed in Japan, where large-scale cultivation of plant cells was successfully realized many years ago (a 20-m 3 biomass reported in 1976) [1].From the standpoint of the commercial growth of cultures, the most efficient technology is that based on bulk cultivation (suspension cell culture). This method reduces the process time and minimizes manual operations as compared

Biometric and phytochemical variability of roseroot (Rhodiola rosea L.) from field cultivation

“…rosea rhizomes with roots can be up to 3.5 kg [16,40]. In Plewiska near Poznań, the fresh weight of the raw material after six years of growing from seeds reached up to 1.7 kg [29], and similarly in Finland -more than 2 kg [3].…”

“…The most important biologically active constituents are phenolics [14]. There are mainly: phenylpropanoids (rosavin, rosin and rosarin), phenyletanoids (salidroside and p-tyrosol), flavonoids, proanthocyanidins as well as tannins [15][16][17][18][19][20].…”

Total Syntheses of Rhodiolosides A and D and of Sachalinols A–C

“…[1][2][3] (-)-Rosiridol itself also occurs in the leaves of Cunila spicata (Lamiaceae) [4] and in the petals of the rose Rosa damascena. [5] (-)-Rosiridin (2) is the β-glucosylated analogue of (-)-rosiridol (1) [6] and has recently been identified as an inhibitor of monoamine oxidase B (MAO B), which is involved in neurodegenerative diseases.…”

Biometric features and content of phenolic compounds of roseroot (Rhodiola rosea L.)

“…In Poland, roseroot grows in the Giant Mountains, Babia Góra, Tatra and Bieszczady Mountains [4][5][6]. For centuries, rhizomes of this species, also known as golden root, arctic root, and Hongjingtian in Chinese, have been an important raw material in folk medicine of Scandinavia, Russia, Mongolia, and China [7][8][9][10]. Traditional use was associated with the adaptogenic properties of this taxon.…”

“…Traditional use was associated with the adaptogenic properties of this taxon. In the last decades, many research studies have found that roseroot increases mental and physical strength as well as it shows anti-stress, cardioprotective, antioxidative, immunomodulatory, and anticancer activities [7,[11][12][13][14]. The above-described features of Rh.…”