Traditional and medicinal use of Barbaloin: potential for the management of various diseases

Abstract

Barbaloin is the phytoconstituent which is obtained from the plant known as aloe vera. As we all know aloe vera is the main curative medicinal plants, has been traditionally used as alternative treatment against the many skin diseases. Barbaloin extracted from the aloe vera plant which is physically light yellow colored powder. Extraction of barbaloin from the plant Aloe barbadensis Miller had been accomplished by the Soxhelt extraction, Batch extraction experiment and Ultrasound assisted extraction method (UAE). Barbaloin showed various kinds of therapeutic and medicinal properties like anti-diabetic, antioxidants, anti-cancer, anti-inflammatory and and anti-microbial. It also has good effect on cardiovascular system, test perception, enzyme or metabolism and bioavailability. Our Skin plays an important role in the development of skin diseases because there are many types of skin disorders are developed and the variety of disorders may result to dermatitis or they affect the social wellbeing of a person. Due to their good pharmacological activities, Barbaloin have great potential to treat the different type of skin disorders like Eczema, Psoriasis, Burns and wound, Acne, Dandruff, Frostbite, Rashes, Cold sores, Razor burn and Sunburn. To access the effective use of barbaloin there are various attempts have been experimented on the subject of their Pharmacological activities to check their effect on skin disease and the steps regarding the Isolation of barbaloin also has been made. We can examine their effects on chronic skin diseases. In this review article we discuss about the potential of barbaloin on skin disorders, medicinal importance or Pharmacological activities and their methods of extraction.

RETRACTED ARTICLE: Barbaloin: an amazing chemical from the ‘wonder plant’ with multidimensional pharmacological attributes

“…The inner gel obtained after the process can be scrapped and then smaller pieces cut from it. Various standardized protocols are available for barbaloin extraction, such as the Soxhlet extraction procedure, ultrasound-assisted extraction methods, batch extraction experiments (Singh et al 2020 ). An elaborate drying process is followed using the solar drying method for 3 weeks at 30–45 ºC.…”

“…Pure barbaloin had been found to inhibit the growth of the bacteria Neisseria gonorrhoeae responsible for causing sexually transmitted disease gonorrhoeae (Kambiz and Afolayan 2008 ; Khare et al 2021 ). Barbaloin, when administered with phyto-extracts from Withania somnifera, was found to show anti-viral properties against the herpes simplex type 1 virus (Singh et al 2020 ). Also, a study by Van et al ( 2002 ) pointed at the anti-plasmodial property of Barbaloin (Van et al 2002 ).…”

“…Barbaloin has been found to possess an antioxidant property by helping in the process of destroying free radicals produced in the process of oxidative stresses taking place within the cell. It exhibited its antioxidant properties in the regions of free radical induced with the deoxyribonucleic acid (DNA) component (Singh et al 2020 ). Barbaloin also offered protection against the OH-induced components of DNA and broke it compared to another control group.…”

“…The highest effect of barbaloin is reduced in a minimum ratio. On the other hand, there was a gradual decrease in the power of the free radical effects of barbaloin, and this may have led to results to protect the component of deoxyribonucleic acid (Singh et al 2020 ). The presence of enzymes glutathione peroxidase, superoxide dismutase enzymes, and phenolic antioxidants were responsible for the antioxidant property of Aloe vera and its phytocomponents (Sharma et al 2014 ).…”

“…Different studies aimed to show the anti-inflammatory action of barbaloin. These compounds had been shown to gradually retard the synthesis of nitric oxide by showing a negative effect on the expression of nitric oxide mRNA (Singh et al 2020 ). Also, the effect was shown with respect to the manufacture of Prostaglandin E2.…”