The patients with pulmonary lobectomy invariably are shifted to the intensive care unit/high-dependency unit after the surgery because these patients can have significant minor and major complications. These complications following pulmonary lobectomy are preventable, and early identification in ICU can lead to reduced morbidity and mortality. Good intensive care management after pulmonary lobectomy can reduce the cost by decreasing the number of days patient stays in the hospital. This chapter will broadly discuss the common complications encountered in ICU after pulmonary lobectomy and approach to manage them.