Traditional Chinese drug ShuXueTong facilitates angiogenesis during wound healing following traumatic brain injury

Jin, Xiaoying; Shen, Gang; Gao, Feng; Zheng, Xiaohang; Xu, Xiaoyan; Shen, Fang; Gu, Li; Gong, Jiangbiao; Wen, Liang; Yang, Xiaofeng; Bie, Xiaodong

doi:10.1016/j.jep.2008.02.033

Cited by 27 publications

(13 citation statements)

References 12 publications

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“…VEGF promotes revascularization of ischemic flaps, thus increasing flap survival [16, 17]. Moreover, Shuxuetong injections enhance VEGF/VEGFR-2 expression in patients with traumatic brain injuries [6, 18]. In the present study, the VEGF expression level was markedly higher in test flaps than in controls.…”

Section: Discussionsupporting

confidence: 46%

“…In Chinese traditional medicine, both components promote blood flow (huo xue), activate meridians (tong luo), and disperse blood stasis (hua yu) [6]. Thus, we logically hypothesized that Shuxuetong might facilitate angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…A Shuxuetong injection is traditionally used in Chinese medicine to treat “blood stasis and stagnation” (yu xue yu zhi), particularly in patients with cerebral and myocardial infarction [6]. The material is extracted from Hirudo leeches and also contains Pheretima (defined below).…”

Section: Introductionmentioning

confidence: 99%

“…The enzyme mediates anticoagulation by activating plasminogen, promoting thrombolysis, and preventing thrombus recurrence. Moreover, recent work has shown that Shuxuetong facilitates angiogenesis during wound healing following traumatic brain injury [6]. In addition, the material has a protective effect on brain tissue subject to ischemia-reperfusion injury, by enhancing expression of gamma-aminobutyric acid (GABA) in the hippocampus [10].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Traditional Chinese Medicine Shuxuetong Injection on Random Skin Flap Survival in Rats

Cai

Huang

Lin

2014

The Scientific World Journal

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Background. A Shuxuetong injection is traditionally used in Chinese medicine to treat “blood stasis and stagnation” (yu xue yu zhi). We investigated the effect of such injection on the survival of random skin flaps. Methods. McFarlane flaps were established in 60 rats divided into two groups. Postoperative celiac injections were given to both groups for 7 days. Shuxuetong was injected into the test group, and saline was injected into controls. On day 7, tissues were stained with H&E (hematoxylin-eosin) stain, immunohistochemically evaluated, and the expression levels of xanthine oxidase were determined. Result. The mean area of flap survival in the test group was significantly higher than in controls. Expression of vascular endothelial growth factor and superoxide dismutase, and microvessel development, were markedly increased in the test group, and the malondialdehyde level was reduced. Conclusion. Shuxuetong promotes random skin flap survival.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Traditional Chinese Medicine Shuxuetong Injection on Random Skin Flap Survival in Rats

Cai

Huang

Lin

2014

The Scientific World Journal

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“…It is possible to shorten the period of wound healing by promoting angiogenesis using various bioactive substances. Many researchers have reported that traditional Chinese drugs (crude drugs) have angiogenesis promoting effects, antimycotic properties, and antiangiogenic functions [8][9][10][11][12][13][14][15] . Yang et al 8) reported that several crude drugs such as Salvia miltiorrhiza Bunge (Danshen), Angelica sinensis (Danggui), Astragalus membranaceus Bunge (Huangqi), and Puerarin radix (Gegen) can promote angiogenesis by acting on proteins such as vascular endothelial growth factor (VEGF).…”

Section: Introductionmentioning

confidence: 99%

The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials

et al. 2017

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This study aimed to determine the effect of crude drugs on the dynamic viscoelasticity and angiogenic property of soft polymer materials, in vitro. Two kinds of polyethyl methacrylates, and crude drugs (Astragalus membranaceus Bunge [HQ] and Salvia miltiorrhiza Bunge [DS]) were used in their powdered forms. And, acetyl tributyl citrate and ethyl alcohol were used in the liquid form. The dynamic viscoelasticity of each specimen was measured after 0, 1, 3, 7, 14 and 28 days of immersion in distilled water. The CellPlayer angiogenesis PrimeKit assay was used to test angiogenesis. Significant differences in dynamic viscoelasticity were observed among the materials. Specimens containing 1 wt% HQ showed higher angiogenic activity than those containing 5 wt% and 10 wt% HQ, and DS. Our results suggest that the addition of low amounts of crude drugs to soft polymer materials may promote angiogenesis in human tissues.

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Identification and Quantification of Characteristic Peptides (Oligopeptides) in Shuxuetong (SXT) Injection by LC–MS/MS

Liu²,

Xing³

et al. 2022

Chromatographia

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Traditional Chinese drug ShuXueTong facilitates angiogenesis during wound healing following traumatic brain injury

Cited by 27 publications

References 12 publications

Effects of Traditional Chinese Medicine Shuxuetong Injection on Random Skin Flap Survival in Rats

Effects of Traditional Chinese Medicine Shuxuetong Injection on Random Skin Flap Survival in Rats

The effect of crude drugs on the angiogenic property and dynamic viscoelasticity of PEMA-based soft polymer materials

Identification and Quantification of Characteristic Peptides (Oligopeptides) in Shuxuetong (SXT) Injection by LC–MS/MS

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