Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation

Chen, Xiaomin; Wen, Ya; Shao, Chen; Jin, Xin; Liu, Chen; Wang, Wei; Kong, Ning; Ling, Dong-Ya; Huang, Qin; Chai, Jin-Er; Zhang, Xiaolei; Li, Jie; Xu, Maosheng; Jiang, Zhong; Du, Hong-Gen

doi:10.3389/fnins.2023.1125677

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…The manipulation can activate the function of the bilateral orbito gyrus, the middle frontal gyrus, the bilateral cuneate lobes, the bilateral inferior frontal gyrus, and the bilateral anterior cingulate gyrus. It increases connectivity between the sensory and executive cortex and inhibits its connection to the cognitive, visual, and memory cortex 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of the mulligan maneuver for cervicogenic headache: a randomized controlled trial

Jin,

Du,

Kong

et al. 2023

Sci Rep

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Cervicogenic headache is an often observed secondary headache in clinical settings, with patients who endure prolonged and persistent pain being particularly susceptible to mood changes. Currently, the Mulligan is one of the effective methods for CEH. However, there is a lack of evaluation about the strength and frequency of headaches, as well as the assessment of pain-induced emotions, in individuals with CEH using this particular procedure. Herein, we aimed to evaluate the effectiveness of the Mulligan maneuver from a multidimensional perspective of pain intensity and mood. A total of forty patients diagnosed with CEH who satisfied the specified inclusion criteria were recruited and allocated randomly into two groups: the control group and the treatment group, with each group consisting of twenty cases. The control group received health education, while the treatment group received the Mulligan maneuver once daily over a course of 10 treatment sessions.The clinical outcome of patients with CEH in two groups was assessed using the Visual Analog Scale (VAS), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD). Resting-state functional magnetic resonance imaging was employed to examine variations in brain function activities between the two CEH groups. Brain regions showing differences were identified as regions of interest and subsequently correlated with clinical behavioral measures using Pearson’s correlation analysis. The differences in VAS, HAMA and HAMD between the two groups of CEH patients were also statistically significant. The brain regions that showed differences in the ReHo scores between the two groups of CEH patients included the left cerebellum, the frontal gyrus, and the middle temporal gyrus. There was a positive correlation between the left frontal gyrus and VAS, HAMA and HAMD. The left middle temporal gyrus had a negative correlation with VAS, HAMA, and HAMD and the left cerebellum had a positive correlation with VAS correlation. The Mulligan maneuver may improve pain levels and have a moderating effect on pain-related negative emotions by regulating the function of relevant brain regions in CEH patients.

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Section: Introductionmentioning

confidence: 99%

Clinical efficacy of the mulligan maneuver for cervicogenic headache: a randomized controlled trial

Jin,

Du,

Kong

et al. 2023

Sci Rep

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Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation

Zhou,

Wu,

Wang

et al. 2024

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Spinal manipulative therapy (SMT) has been shown to significantly alleviate pain in patients with lumbar disc herniation (LDH), with its effects closely associated with brain function modulation. This study investigates the neural biomarkers linked to pain relief efficacy following a complete SMT treatment cycle in LDH patients. A total of 59 LDH patients were randomized into two groups: SMT treatment (Group 1, n = 28) and sham treatment (ST) (Group 2, n = 31). A matched healthy control group (Group 3, n = 28) was also included. Functional magnetic resonance imaging (fMRI) was performed on LDH patients at two time points (TPs)—before (TP1) and after (TP2) treatment—while healthy controls were scanned once. Clinical assessments were conducted using the Visual Analogue Scale (VAS) and the Japanese Orthopaedic Association (JOA) scale. Post-treatment results indicated significant improvements in both VAS and JOA scores for Group 1, while the improvement was limited to VAS scores for Group 2. Graph properties analysis revealed notable differences in brain network connectivity between LDH patients and healthy controls, particularly between the left precentral gyrus (left PreCG) and left inferior frontal gyrus, opercular part (left IFGoperc). Enhanced functional connectivity (FC) was observed in Group 1, notably between the right angular gyrus (right ANG) and the left middle orbital gyrus (left ORBmid), with right ANG showing a significant positive correlation with clinical scores. This study identifies the sensorimotor network—salience network are significantly activated in chronic pain among LDH patients. The default mode network—dorsal attention network may serve as key neural biomarkers for the efficacy of SMT treatment in alleviating pain in LDH.

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Clinical Efficacy of the Mulligan Maneuver for Cervicogenic Headache: A Randomized Controlled Trial

Jin,

Du,

Kong

et al. 2023

Preprint

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Background Cervicogenic headache is an often observed secondary headache in clinical settings, with patients who endure prolonged and persistent pain being particularly susceptible to mood changes.Currently, the Mulligan is one of the effective methods for CEH. However, there is a lack of evaluation about the strength and frequency of headaches, as well as the assessment of pain-induced emotions, in individuals with CEH using this particular procedure. Herein, we aimed to evaluate the effectiveness of the Mulligan maneuver from a multidimensional perspective of pain intensity and mood. Methods༚ A total of forty patients diagnosed with CEH who satisfied the specified inclusion criteria were recruited and allocated randomly into two groups: the control group and the treatment group, with each group consisting of twenty cases. The control group received health education, while the treatment group received the Mulligan maneuver once daily over a course of 10 treatment sessions.The clinical outcome of patients with CEH in two groups was assessed using the Visual Analog Scale (VAS), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD). Resting-state functional magnetic resonance imaging (fMRI) was employed to examine variations in brain function activities between the two CEH groups. Brain regions showing differences were identified as regions of interest (ROI) and subsequently correlated with clinical behavioral measures using Pearson's correlation analysis. Results The differences in VAS, HAMA and HAMD between the two groups of CEH patients were also statistically significant (P < 0.05). The brain regions that showed differences in the ReHo scores between the two groups of CEH patients included the left cerebellum, the frontal gyrus, and the middle temporal gyrus. There was a positive correlation between the left frontal gyrus and VAS, HAMA and HAMD. (R2 = 0.48, P < 0.05; R2 = 0.28, P < 0.05; R2 = 0.26, P < 0.05); the left middle temporal gyrus had a negative correlation with VAS, HAMA, and HAMD. (R2 = 0.44, P < 0.05; R2 = 0.43, P < 0.05; R2 = 0.25, P < 0.05); and the left cerebellum had a positive correlation with VAS correlation (R2 = 0.27, P < 0.05). Conclusion The Mulligan maneuver may improve pain levels and have a moderating effect on pain-related negative emotions by regulating the function of relevant brain regions in CEH patients.

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Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation

Cited by 6 publications

References 41 publications

Clinical efficacy of the mulligan maneuver for cervicogenic headache: a randomized controlled trial

Clinical efficacy of the mulligan maneuver for cervicogenic headache: a randomized controlled trial

Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation

Clinical Efficacy of the Mulligan Maneuver for Cervicogenic Headache: A Randomized Controlled Trial

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