Traditional Chinese medical therapy for erectile dysfunction

Li, Hao; Jiang, Hongyang; Liu, Jihong

doi:10.21037/tau.2017.03.02

Cited by 27 publications

(16 citation statements)

References 44 publications

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“…In China, traditional herbs or formulas to treat ED are widespread and recognized for their effectiveness [12, 13]. The basic pathogenesis of ED after radical prostatectomy, in terms of traditional Chinese medicine, is considered a Qi deficiency and dysregulated blood stasis [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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HongJing I (HJI), a traditional Chinese herbal formula, has been confirmed to be effective for the clinical treatment of erectile dysfunction (ED). However, the mechanism of action of HJI remains unclear. Here, we aimed to investigate the effect and underlying mechanisms of HJI against ED in a rat model of bilateral cavernous nerve injury (BCNI). Rats were divided into five groups: normal control (NC), BCNI-induced ED model (M), M + low-dose HJI (HL), M + medium-dose HJI (HM), and M + high-dose HJI (HH). All groups were treated with normal saline or the relevant drug for 28 consecutive days after inducing BCNI-ED. At the end of the treatment period, the intracavernous pressure (ICP) was recorded, and histological examination was conducted using Masson’s trichrome staining. Immunofluorescence staining and western blotting were applied to detect the changes in fibrosis protein and Ras homolog A (RhoA), Rho-associated protein kinase 1 (ROCK1), and ROCK2 expression. We found that HJI effectively improved the ICP in the treatment groups. In addition, RhoA, ROCK1, and ROCK2 expression levels were increased upon BCNI-ED induction, and HJI successfully inhibited cavernosum fibrosis and the activation of RhoA/ROCK2 signaling. Overall, these results suggest that the effects of HJI in attenuating ED may be caused, at least in part, by the suppression of RhoA/ROCK2 signaling and alleviation of fibrosis. However, the precise mechanism surrounding this requires further investigation in future studies.

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Section: Introductionmentioning

confidence: 99%

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…In China, 5,000 years of written and recorded history of traditional Chinese medicine has benefited the people living there. Moreover, China is rich in Chinese herbal medicine resources and Chinese herbs have played a role in treating ED (Li et al., 2017; Wang et al., 2020). Our team is devoted to finding additional therapeutic herbs for use with CN‐injured ED.…”

Section: Discussionmentioning

confidence: 99%

Enhanced effects of salidroside on erectile function and corpora cavernosa autophagy in a cavernous nerve injury rat model

Zhao

et al. 2021

Andrologia

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We explored the efficacy and mechanisms of salidroside treatment for erectile dysfunction induced by bilateral cavernous nerve injury (BCNI). Forty male rats were divided into four groups as follows: sham (cavernous nerves exposed only) (S); BCNI (M); BCNI + rapamycin (M + rapamycin); and BCNI + salidroside (M + salidroside). Erectile function in the rats was measured by intracavernosal pressure. Penile tissue was harvested for transmission electron microscopy, immunohistochemistry, immunofluorescence, Masson's trichrome staining, haematoxylin–eosin staining, TdT‐mediated dUTP Nick End Labeling and western blotting. The M group exhibited a decrease in erectile responses and increased apoptosis and fibrosis compared to these in the S group. Meanwhile, nerve content and the penile atrophy index were also decreased in the M group. Treatment with salidroside and rapamycin for 3 weeks partially restored erectile function and significantly attenuated corporal apoptosis, fibrosis, nerve content and penile atrophy in the M group. Moreover, the autophagy level was further enhanced in the M + salidroside group, which was the same as that in the positive observation group (M + rapamycin). Salidroside treatment not only improved erectile function in rats with BCNI, but also inhibited apoptosis and fibrosis and ameliorated the loss of nerve content and endothelial and corpus cavernosum smooth muscle cells by promoting protective autophagy.

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“…Considering the kidney yang-tonifying effect of cistanche, and kidney is a critical organ related with sexual function from the TCM perspective [22], we additionally collected SLQ questionnaire in the current study. Different from the male subjects who achieved all items improved, female subjects failed 2 items, which were ease of insertion and partner's overall pleasure of lovemaking.…”

Section: Discussionmentioning

confidence: 99%

A botanical product containing cistanche and ginkgo extracts improves chronic fatigue syndrome: a randomized, double-blind, placebo-controlled study

Kan¹,

Hu²,

Chen³

et al. 2020

Preprint

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BackgroundDietary therapy may be beneficial in alleviating symptoms of chronic fatigue syndrome (CFS), a disorder characterized by extreme fatigue with no underlying medical condition. The aim of this study is to evaluate the protective effect of a botanical product containing cistanche (Cistanche tubulosa (Schenk) Wight) and ginkgo (Ginkgo biloba L.) extracts on adults with CFS in a randomized, double-blind, placebo-controlled clinical trial.MethodsA total of 190 subjects with CFS were randomized to receive low dose, high dose of product or placebo (tablets) once daily for 60 days. Blood samples and questionnaires of Chalder fatigue, quality of life (QOL), and sexual life quality (SLQ) were collected at baseline and post-intervention.ResultsOur product significantly relieved the symptoms of CFS, among which impaired memory or concentration, muscle pain, unrefreshing sleep, and post-exertional malaise were significantly improved. The intervention of product significantly decreased both physical and mental fatigue scores of the Chalder fatigue questionnaire, and improved QOL and SLQ of the subjects. Levels of blood ammonia and lactic acid in the subjects of product group were significantly lower than those of placebo group. In addition, the change in lactic acid concentration was significantly associated with the effectiveness for CFS symptoms, and correlated to the change in total physical fatigue score of the Chalder fatigue questionnaire.ConclusionsOur botanical product relieves the CFS symptoms and improves the scores of Chalder fatigue, QOL and SLQ questionnaires. These findings suggest a nutritional supplementation approach with botanical extracts as an alternative strategy in mitigating CFS.Trial registrationThis trial has been registered on https://clinicaltrials.gov/ under the identification code: NCT02807649. Registered 21 June 2016 - Retrospectively registered.

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Traditional Chinese medical therapy for erectile dysfunction

Cited by 27 publications

References 44 publications

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury

Enhanced effects of salidroside on erectile function and corpora cavernosa autophagy in a cavernous nerve injury rat model

A botanical product containing cistanche and ginkgo extracts improves chronic fatigue syndrome: a randomized, double-blind, placebo-controlled study

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