Traditional Chinese medication for cardiovascular disease

Hao, Panpan; Jiang, Fan; Chen, Yuguo; Yang, Jianmin; Zhang, Kai; Zhang, Mingxiang; Zhang, Cheng; Zhao, Yong; Zhang, Yun

doi:10.1038/nrcardio.2014.177

Cited by 102 publications

(75 citation statements)

References 23 publications

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“…Management of vascular risks and symptoms is the primary approaches in treating vascular dementia, and TCM has proven ability to treat cardiovascular diseases and hypertension effectively [3, 13]. Moreover, TCM formulations for the treatment of dementia-like and memory disorders have been extensively documented in the classical Chinese medical literature, including herbs such as Salvia miltiorrhiza , Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, and Panax ginseng [14–16].…”

Section: Introductionmentioning

confidence: 99%

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Zhou

Cui

Tseng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer's disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).

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Section: Introductionmentioning

confidence: 99%

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Zhou

Cui

Tseng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…Cardiovascular diseases account for a large percentage of disease-related deaths worldwide, and as such, the discovery of novel drugs or compounds among traditional herbal medicines that have cardiovascular protective effects is a focus of intense research (Hao et al, 2015;Yao et al, 2015). Research on the cardiovascular pharmacology of ginseng has aroused great interest among scholars in recent years.…”

Section: Introductionmentioning

confidence: 99%

Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives

Sun

Liu

Chen

2016

Sci. China Life Sci.

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Ginseng is among the oldest traditional Chinese medicinal herbs and is widely used in China and Southeast Asia. Over the past 50 years, considerable research has focused on the chemical constituents, pharmacological action, and clinical applications of ginseng. In this review, we examine the current state of research on ginseng, including the main active ingredient ginsenoside, its pharmacological effects on the cardiovascular system, and mechanisms of action. We focus on what is known of the effects of ginseng against atherosclerosis, arrhythmia, myocardial ischemia, and its inhibition of ventricular remodeling, providing a basis for expanding the clinical applications of ginseng.

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“…To provide high quality of evidence for clinical practice, well-designed, large-scale, multicenter RCTs are recommended (65,66). Definitively, RCTs are necessary to provide evidence for the average efficacy of dispensing granules comparing with traditional decoction.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of dispensing granules with traditional decoction: a systematic review and meta-analysis

et al. 2018

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as effective as the traditional decoction kept unclear. This systematic review and meta-analysis was made to assess the efficacy of dispensing granules compared with traditional decoction. Methods:We searched four databases since their inception to 9th September in 2016. Two authors independently identified trials, extracted data and assessed risk of bias with Cochrane Reviewer's Handbook 5.0. We conducted meta-analysis with RevMan 5.1.0 software for eligible and appropriate trials.Results: In the end, 7,035 participants from 51 randomized controlled trials (RCTs) which compared dispensing granules with traditional decoction were included in this systematic review. There were 33 different kinds of diseases for investigation, of which 8 RCTs observed common cold, 4 RCTs observed migraine. For rheumatoid arthritis, insomnia and hypertension, there were 3 RCTs reported respectively.The last RCTs reported different kinds of diseases in one or two trials. The majority of trials were in low methodological quality. Thirty-eight (74.5%) RCTs showed that the efficacy of dispensing granules were similar with traditional decoction, 6 (11.8%) RCTs reported that the therapeutic efficacy of dispensing granules were significantly better than traditional decoction. We conducted meta-analysis for 4 trials investigating patients with migraine. The results showed that dispensing granules reduced headache frequency by about 1.03 attacks per month as compared to traditional decoction. No evidence was found in terms of migraine intensity and duration. Conclusions:The low quality of RCTs and conflicting results made it difficult to draw a definite conclusion. In the future, it needs much more evidence to explore the efficacy and safety of dispensing granules. N-of-1 trials and fuzzy comprehensive evaluation methods may be better choices for assessing the efficacy of them than RCTs.

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Traditional Chinese medication for cardiovascular disease

Cited by 102 publications

References 23 publications

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives

Comparison of the efficacy of dispensing granules with traditional decoction: a systematic review and meta-analysis

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