Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease

Zhu, Zhou; Zhang, Shiqing; Lui, Cathy N. P.; Zhu, Peili; Zhang, Zhang; Lin, Kaili; Dai, Yiwu; Yung, Ken Kin-Lam

doi:10.26599/jnr.2019.9040026

Cited by 21 publications

(4 citation statements)

References 93 publications

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“…Traditional Chinese medicine (TCM) is considered a huge source of novel drugs and compounds for therapy in neurological diseases [3]. Ginseng (Panax ginseng), a popular herb used in TCM, has been confirmed to play a protective role in cerebral ischemia in vivo [4].…”

Section: Introductionmentioning

confidence: 99%

Oleanolic Acid Alleviates Cerebral Ischemia/Reperfusion Injury via Regulation of the GSK-3β/HO-1 Signaling Pathway

et al. 2021

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Oleanolic acid (OA), a bioactive ingredient of Panax ginseng, exhibits neuroprotective pharmacological effects. However, the protective role of OA in cerebral ischemia and involved mechanisms remain unclear. This study attempted to explore the therapeutic effects of OA both in vitro and in vivo. OA attenuated cytotoxicity and overproduction of intracellular reactive oxygen species (ROS) by regulation of glycogen synthase kinase-3β (GSK-3β)/heme oxygenase-1 (HO-1) signal in oxygen-glucose deprivation/reoxygenation (OGD/R)-exposed SH-SY5Y cells. Additionally, OA administration significantly reduced the area of cerebral infarction and the neurological scores in the rat models of cerebral ischemia with middle cerebral artery occlusion (MCAO). The OA administration group showed a higher percentage of Nissl+ and NeuN+ cells, along with lower TUNEL+ ratios in the infarct area of MCAO rats. Moreover, OA administration reduced ROS production while it suppressed the GSK-3β activation and upregulated the HO-1 expression in infarcted tissue. Our results illustrated that OA significantly counteracted cerebral ischemia-mediated injury through antioxidant effects induced by the regulation of the GSK-3β/HO-1 signaling pathway, implicating OA as a promising neuroprotective drug for the therapy of ischemic stroke.

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Section: Introductionmentioning

confidence: 99%

Oleanolic Acid Alleviates Cerebral Ischemia/Reperfusion Injury via Regulation of the GSK-3β/HO-1 Signaling Pathway

et al. 2021

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“…It may also minimize the side effects of conventional medications. 78,109,140 These benefits may be helpful to lessen suffering and improve the quality of life of animal patients in their aging years. It is hoped that this study will lead to new knowledge and awareness of the potential benefits of TCVM therapy in treating CCD.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Traditional Chinese Veterinary Medicine in the Treatment of Cognitive Dysfunction: A Systematic Review and Meta-Analysis

Nokay,

Shiau

2022

American Journal of Traditional Chinese Veterinary Medicine

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The objective of this systematic review study was to assess the efficacy of traditional Chinese medicine (TCM) or traditional Chinese veterinary medicine (TCVM) in the treatment of cognitive dysfunction. The study considered the similarities in Alzheimer’s disease (AD) and canine cognitive dysfunction (CCD). The initial literature search resulted in 573 relevant clinical and nonclinical studies. Three categories of controlled clinical trials in AD patients were selected for review: placebo control (20), conventional medicine control (126), and integrated treatment (183). The studies were reviewed and those that met the inclusion criteria were selected for meta-analysis. The review found that 10 placebo-controlled studies, 38 conventional medicine-controlled studies, and 38 integrated studies were qualified for meta-analysis. In placebo-controlled studies, meta-analyses based on improvements in Mini-Mental State Examination (MMSE) and Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) found statistical significance in the MMSE (p=8.74×10-7), ADAS-cog (p=0.0085), and overall p-value (p=3.66×10-17), suggesting that the TCM treatments were significantly more effective than placebo. In conventional treatment-controlled studies, results from the meta-analyses also suggest that TCM treatments were significantly more effective than conventional treatments based on the overall p-value (p=1.67×10-23) and improvement in MMSE (p=0.0002). In the integrated treatment studies, the meta-analyses findings suggest that TCM-integrated treatments were significantly more effective than conventional treatments alone (overall p-value: p=1.82×10-48 and p=0.0050 in MMSE improvements). Based on this systematic review and considering the similarities in pathology in the human and canine, TCVM may be helpful to lessen suffering and improve the quality of life in patients with canine cognitive dysfunction.

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“…Data has showed that the expression of hsa-miR-221-3p, hsa-miR-214-3p, hsa-miR-29c-3p, and miR-124 family is meaningful for the diagnosis of PD [ 7 – 10 ]. Meanwhile, some scholars believe that miRNA has great potential in treating PD [ 9 – 14 ]. The abnormal expression of miR-9-5p in neurodegenerative diseases would sabotage its neuroprotective effect [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-9-5p Inhibits the MMP+-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson’s Disease

Xiao

Yan

Sun

et al. 2022

Oxidative Medicine and Cellular Longevity

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The pathogenesis of Parkinson’s disease remains unclear that there is no cure for Parkinson’s disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson’s disease. Here, we demonstrate that miR-9-5p inhibits the dopaminergic neuron apoptosis via the regulation of β-catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR-9-5p improved the motor function of mice with Parkinson’s disease. The results of this study suggest that miR-9-5p might be a potential therapeutic target against Parkinson’s disease.

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Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease

Cited by 21 publications

References 93 publications

Oleanolic Acid Alleviates Cerebral Ischemia/Reperfusion Injury via Regulation of the GSK-3β/HO-1 Signaling Pathway

Oleanolic Acid Alleviates Cerebral Ischemia/Reperfusion Injury via Regulation of the GSK-3β/HO-1 Signaling Pathway

Efficacy of Traditional Chinese Veterinary Medicine in the Treatment of Cognitive Dysfunction: A Systematic Review and Meta-Analysis

MiR-9-5p Inhibits the MMP+-Induced Neuron Apoptosis through Regulating SCRIB/β-Catenin Signaling in Parkinson’s Disease

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