Traditional Chinese Medicine constitution types of high-normal blood pressure: A meta-analysis

Mu, Ting-Yu; Zhu, Qianyin; Chen, Ling-shan; Dong, Die; Xu, Jiayi; Xu, Rixiang; Shen, Cui-zhen

doi:10.1016/j.heliyon.2023.e13438

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Over the past few years, there has been a proposal and enhancement of systematic constitutional theory in traditional Chinese medicine (TCM) 8 . TCM constitutions have been extensively studied in a variety of diseases 9–11 . According to Chinese medicine, the constitution of the body is a relatively stable characteristic inherent in the morphological structure and functional activities of human individuals, formed by congenital inheritance and acquisition 11 .…”

Section: Introductionmentioning

confidence: 99%

“… 8 TCM constitutions have been extensively studied in a variety of diseases. 9 , 10 , 11 According to Chinese medicine, the constitution of the body is a relatively stable characteristic inherent in the morphological structure and functional activities of human individuals, formed by congenital inheritance and acquisition. 11 The differences in individual physique are reflected in certain differences in response and adaptation to external stimuli in the physiological state, as well as in susceptibility to certain pathogenic factors in the pathogenesis process and in the tendency for disease development.…”

Section: Introductionmentioning

confidence: 99%

“… 9 , 10 , 11 According to Chinese medicine, the constitution of the body is a relatively stable characteristic inherent in the morphological structure and functional activities of human individuals, formed by congenital inheritance and acquisition. 11 The differences in individual physique are reflected in certain differences in response and adaptation to external stimuli in the physiological state, as well as in susceptibility to certain pathogenic factors in the pathogenesis process and in the tendency for disease development. 12 , 13 Hence, investigating body constitutions aids in scrutinizing the emergence and progression of illnesses, thereby establishing a foundation for diagnosing and treating ailments.…”

Section: Introductionmentioning

confidence: 99%

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The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia

Nie,

Wang,

Zhang

et al. 2024

Aging Medicine

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ObjectiveSarcopenia is a geriatric syndrome that occurs with age and is characterized by a gradual decline in muscle mass, power, and functionality. It serves as a prominent contributor to frailty, disability, and mortality among older individuals. Currently, no standardized global guidelines exist for the diagnosis of sarcopenia. This study aimed to establish the correlation between sarcopenia and the constitutions of traditional Chinese medicine (TCM), considering the connection between physical functioning and sarcopenia.MethodsA total of 1441 participants in this study were diagnosed with sarcopenia. The Asian Working Group for Sarcopenia (AWGS) proposed a sarcopenia definition algorithm. To determine the constitution of each participant, classification and determination standards were used in traditional Chinese medicine. This study evaluated the demographics, lifestyles, and self‐reported medical history of individuals diagnosed with sarcopenia through a self‐administered questionnaire. The constitution of the participants was determined using TCM classification and determination standards. Subsequently, we analyzed the results of univariate analysis and multivariate regression and constructed a receiver operating characteristic (ROC) curve.ResultsParticipants who were diagnosed with sarcopenia had substantially lower original Neutral constitution scores (P < 0.050). In comparison to those without sarcopenia, individuals with sarcopenia exhibited notably elevated original Qi‐deficiency, Yang‐deficiency, Yin‐deficiency, Blood‐stagnation, and Qi‐stagnation scores in contrast to those in the healthy group (P < 0.050). The identified risk factors associated with sarcopenia included the following: Neutral (OR = 0.903), Qi‐deficiency (in males, OR = 1.126), Yang‐deficiency (OR = 1.062), Phlegm‐dampness (in males, OR = 0.833), and Blood‐stagnation (in females, OR = 1.089). The highest area under the curve (AUC) was observed for the original neutral constitution score, followed by the Yang‐deficiency and blood‐stagnation scores (0.644, 0.613, and 0.611, respectively). Additionally, the AUC for the combined original scores of all nine constitutions among males reached 0.778.ConclusionsIn this cross‐sectional study of older people with higher original Qi‐deficiency, Yin deficiency, Yang‐deficiency, Blood‐stagnation, and Qi‐stagnation were associated with sarcopenia. Notably, various TCM constitutions are significantly linked to sarcopenia. There was a significant occurrence of various body constitution types among individuals diagnosed with sarcopenia. The mixture of the nine original constitution scores exhibited good diagnostic performance for sarcopenia in males.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia

Nie,

Wang,

Zhang

et al. 2024

Aging Medicine

View full text Add to dashboard Cite

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An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty

Gu,

Wang,

Yang

et al. 2024

Clinical and Translational Dis

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IntroductionAs global population ages, frailty has surfaced as a major public health challenge. Given the heterogeneity of frailty in the clinical presentation, it is imperative to develop personalised diagnostic and treatment strategies. The traditional Chinese medicine (TCM) constitution offers notable advantages in discerning individual differences. This study aims to elucidate the association between TCM constitutions and frailty, providing insights into the application of TCM for the frailty management.MethodsAn observational study was conducted at Huadong hospital from July 2022 to November 2023. A total of 241 older patients were recruited. Each patient underwent assessments for the TCM constitution and frailty status. Comprehensive data collection encompassed medical history, biochemical indicators, bone mineral density (BMD), body composition and physical performance metrics. Plasma samples were also collected to detect levels of inflammatory factors and lymphogenesis‐related factors, including IL‐1β, TNF‐α, VEGF‐C, ANGPTL4 and ACV‐A. Multi‐level statistical analysis was used to establish the relationship of TCM constitutions with frailty.ResultsAmongst all participants, 54 individuals were classified as non‐frail, 90 individuals as pre‐frail and 97 individuals as frail. Regression analysis indicated that frailty was closely associated with four imbalanced TCM constitutions: Qi deficiency, phlegm dampness, blood stasis and Qi depression. Subsequent analysis demonstrated that Qi deficiency was associated with decreased BMD, phlegm dampness with elevated high‐density lipoprotein levels, Blood stasis with elevated blood glucose levels, and Qi depression with both decreased BMD and elevated low‐density lipoprotein levels. Furthermore, individuals characterised by imbalanced TCM constitutions exhibited inferior handgrip strength, walking pace, lower limb strength and higher levels of inflammatory factors and lymphogenesis‐related factors compared to those with balanced TCM constitution.ConclusionFrailty is independently associated with Qi deficiency, phlegm dampness, blood stasis and Qi depression. Personalised diagnostic approaches based on the TCM constitution may offer valuable insights for directing treatment for older patients with frailty.

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Confidence interval for normal means in meta-analysis based on a pretest estimator

Taketomi,

Chang,

Konno

et al. 2023

Jpn J Stat Data Sci

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Traditional Chinese Medicine constitution types of high-normal blood pressure: A meta-analysis

Cited by 5 publications

References 24 publications

The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia

The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia

An auxiliary diagnostic approach based on traditional Chinese medicine constitutions for older patients with frailty

Confidence interval for normal means in meta-analysis based on a pretest estimator

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