Traditional Chinese Medicine for Cardiovascular Disease

Hao, Panpan; Jiang, Fan; Cheng, Jing; Ma, Lianyue; Zhang, Yun; Zhao, Yong

doi:10.1016/j.jacc.2017.04.041

Cited by 439 publications

(256 citation statements)

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“…8,9) The knowledge of the antioxidant properties of natural and synthetic molecules is an important requirement for investigations in the fields of biochemistry, biology, food chemistry, and other disciplines. It is of particular significance in the nutritional, pharmacological and health fields, for the prevention of diseases due to unbalanced diet and cell aging.…”

Section: -7)mentioning

confidence: 99%

Semi-synthesis of Twelve Known 20Z/E Pseudo-Ginsenosides and Their Comparative Study of Antioxidative Activity in Free Radical Induced Hemolysis of Rabbit Erythrocytes

Chen

Zhang

et al. 2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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SummaryTweleve pseudo-ginsensides were synthesized under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. The inhibitory effects of these tweleve pseudo-ginsenosides were screened on the hemolysis of rabbit erythrocytes caused by 2,2 ' -azobis (2-amidinopropane hydrochloride) (AAPH). It was found that the IC 50 values followed the sequence of (20Z) pseudo-protopanaxatriol (pseudo-PPT) < (20Z) pseudo-protopanaxadiol (pseudo-PPD) < (20Z) pseudo-Rh2 < (20E) pseudo-PPT< (20E) pseudo-PPD < (20E) pseudo-Rh2 < (20Z) pseudo-Rg2 < (20E) pseudo-Rg2 < Rb1 < (20Z) pseudo-Rh1 < Rg2 < (20E) pseudo-Rh1. These compounds can be divided into three groups: accelerate the hemolysis group (7, 8), weak group (2, 11, 12) and strong group (others).Moreover, we also find that most of the Z configuration has better antioxidative activity than E configuration and the number and type of sugar moieties to the ring of triterpene dammarane influence the antioxidative activity.

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Section: -7)mentioning

confidence: 99%

Semi-synthesis of Twelve Known 20Z/E Pseudo-Ginsenosides and Their Comparative Study of Antioxidative Activity in Free Radical Induced Hemolysis of Rabbit Erythrocytes

Chen

Zhang

et al. 2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Efficacy and clearly demonstrated mechanism theories from dietary plants and herbs are widely used in alternative medicines. Because of the various therapeutic capabilities, active compounds isolated from herbs and plants are well described [16,17]. One of the effective compounds from TMC is resveratrol (RES), which has beneficial effects of supplementation in humans and animals that are widely studied, but studies during pregnancy on animal metabolic health are limited.…”

Section: Introductionmentioning

confidence: 99%

Positive Roles of Resveratrol in Early Development of Testicular Germ Cells against Maternal Restraint Stress in Mice

Mustafa

Ennab

Nazar

et al. 2020

Animals

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Our present study was designed to evaluate the effects of resveratrol (RES) in Swiss mice by exposing them to prenatal stress. Twenty-four Swiss mice were divided into four groups: control (C), maternal restraint stress (MRS), maternal restraint stress + resveratrol (MRS + RES) 2 mg, and maternal restraint stress + resveratrol (MRS + RES) 20 mg. Dams were exposed to stress by restraint in plastic tubes for four hours a day from 12–18 days of gestation. The results showed that male pups of MRS were significantly decreased in the testis weight, anogenital distance, area of seminiferous tubules, diameter of seminiferous tubules, area of the lumen, diameter of the lumen, and epithelial height of seminiferous tubules. However, the anomalies of the reproductive tract produced under restraint stress were neutralized by the use of RES 2 mg/kg. A significant difference was observed between terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)- positive germ cells in MRS and MRS + RES 20 mg/kg groups, while it was non-significant between MRS + RES 2 mg/kg and C groups. Apart from these effects, blood glucose levels were increased in MRS and MRS + RES 20 mg/kg groups, while experimental animals of the MRS + RES 2 mg/kg group significantly recovered. These results suggested that a lower dose of RES could cure the adverse effects of prenatal stress in early age male progeny. Thus, our study suggests, for the first time, practical values for a lower dose of RES 2 mg/kg as a safe and effective agent in the first week age of prenatally stressed mice.

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“…As a kind of TCM product with national quality standards, traditional Chinese patent medicine (TCPM) has been registered and sold in various countries around the world [33]. e antihypertensive effect of TCPMs has been proven to be safe and effective, which made it a good substitute for western medicine intolerance patients [34]. Cardiovascular experts have reached a consensus on the treatment of hypertension with TCPMs.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Patent Medicine for Primary Hypertension: A Bayesian Network Meta‐Analysis

Chen

Shi

Tan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Traditional Chinese Patent Medicine (TCPM) is now being used more and more extensively for primary hypertension in China. However, the comparative efficacy and safety of it need more clarified evidence. Thus, we conducted a Bayesian network meta-analysis to compare TCPMs with other interventions. Methods. We searched China National Knowledge Infrastructure (CNKI), WanFang Data, PubMed, Embase, and Cochrane Library from inception to April 2019 for randomized controlled trials (RCTs) with diagnosis of primary hypertension that compared the efficacy of TCPMs with antihypertension drugs (ADs). Two researchers screened literature, extracted data, and evaluated risk of bias independently. The primary outcomes were systolic blood pressure (SBP) and diastolic blood pressure (DBP). The secondary outcomes were adverse effects (AEs), total cholesterol (TC), and triglyceride (TG). We used the Bayesian network meta-analysis to compare interventions and described the categorical variable and the continuous variable as odds ratio (OR) and mean difference (MD), respectively. Besides, we ranked all interventions via the Surface Under the Cumulative Ranking (SUCRA) values and conducted metaregression with nine covariates as additional analysis. Results. We included 192 studies with 23366 patients diagnosed as primary hypertension in total. For SBP reduction, eighteen interventions were significantly better than AD. Among them, Yinxingye (YXY) + AD (MD = −12, 95% CrI [−16, −8.5]) was superior to others in the rank plot with SUCRA 0.91. For DBP reduction, sixteen interventions were significantly better than AD. Among them, Qinggan Jiangya (QGJY) + AD (MD = −8.7, 95% CrI [−12, −5.5]) and Qiju Dihuang (QJDH) + AD (MD = −8.8, 95% CrI [−12, −5.2]) were superior to others in the rank plot with SUCRA 0.89. To summarize the SUCRA values, we found that QGJY + AD and YXY + AD had the most significant reductions for both SBP and DBP. YXY + AD was the best one for both TC (MD = −1.3, 95% CrI [−1.9, −0.64]) and TG (MD = −0.52, 95% CrI [−0.92, −0.11]) reductions. Considering adverse effects, we found two interventions had significant differences comparing with AD. Among them, YXY + AD was the best one with SUCRA of 0.01. Conclusion. In all TCPMs, QGJY + AD and YXY + AD may be the best options for hypertension. Meanwhile, YXY + AD can improve blood lipids in patients with hypertension. However, due to the vague reports of adverse effects and other limitations, more evidence, especially that provided by high-quality studies, is needed to prove the advantages of TCMPs.

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Traditional Chinese Medicine for Cardiovascular Disease

Cited by 439 publications

References 50 publications

Semi-synthesis of Twelve Known 20<i>Z</i>/<i>E</i> Pseudo-Ginsenosides and Their Comparative Study of Antioxidative Activity in Free Radical Induced Hemolysis of Rabbit Erythrocytes

Semi-synthesis of Twelve Known 20<i>Z</i>/<i>E</i> Pseudo-Ginsenosides and Their Comparative Study of Antioxidative Activity in Free Radical Induced Hemolysis of Rabbit Erythrocytes

Positive Roles of Resveratrol in Early Development of Testicular Germ Cells against Maternal Restraint Stress in Mice

Traditional Chinese Patent Medicine for Primary Hypertension: A Bayesian Network Meta‐Analysis

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