Traditional Chinese Medicine for Cardiovascular Disease: Evidence and Potential Mechanisms

Hao, Panpan; Jiang, Fan; Cheng, Jie; Ma, Lihong; Zhang, Y.; Zhao, Yuanyuan; Wiebrecht, Axel

doi:10.1016/s0415-6412(17)30083-8

Cited by 56 publications

(64 citation statements)

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“…A growing number of studies have demonstrated the protective cardiovascular effects of Chinese herbal medicines . Tongguan capsule (Chinese national patent number: CN101647856A) has long been used to treat ischaemic heart diseases, including acute coronary syndrome and angina pectoris in clinical practice .…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] A growing number of studies have demonstrated the protective cardiovascular effects of Chinese herbal medicines. [13][14][15] Tongguan capsule (Chinese national patent number: CN101647856A) has long been used to treat ischaemic heart diseases, including acute coronary syndrome and angina pectoris in clinical practice. [16][17][18][19][20] Previous data have shown that Tongguan capsules decrease infarct size, mitigate ventricular remodelling and prevent ischaemia/reperfusion arrhythmia occurrence in MI animal models.…”

Section: Introductionmentioning

confidence: 99%

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Tongguan capsule‐derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts

Guo

et al. 2018

J Cellular Molecular Medi

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Tongguan capsule is a compound Chinese medicine used to treat ischaemic heart diseases. This study aimed to investigate whether Tongguan capsule‐derived herb (TGD) has a preventive effect on atrial fibrillation (AF) in post‐myocardial infarction (MI) rats and to determine the underlying mechanisms. MI was induced by ligation of the left anterior descending coronary artery. TGD was administered to the post‐MI rats over a 4‐week period. The TGD‐treated rats had lower rates of AF inducibility and shorter AF durations than the MI rats. TGD improved the left atrial (LA) conduction velocity and homogeneity. It reduced the fibrosis‐positive areas and the protein levels of collagen types I and III in the left atrium. In vitro, it inhibited the expression of collagen types I and III by inhibiting the proliferation, migration, differentiation and cytokine secretion of cardiac fibroblasts (CFs). In conclusion, the current study demonstrated that TGD reduces susceptibility to AF and improves LA conduction function in rats with post‐MI by inhibiting left atrial fibrosis and modulating CFs. Targeting the CF population may be a novel antiarrhythmic therapeutic approach.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tongguan capsule‐derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts

Guo

et al. 2018

J Cellular Molecular Medi

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“…Some of them had also taken IHD or CHD as whole to assess the e cacy of TCM. Panpan Hao et al 39 had evaluated TCM therapy for several CVD risk factors, atherosclerotic cardiovascular disease (ASCVD) and CHF in 1 study. They included RCTs published in the past decade with a relatively strict criteria.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine for ischemic heart disease: clinical manifestations and objective indicators

Liao

Tian

Shao

et al. 2020

Preprint

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Background: The clinical practice of Traditional Chinese medicine (TCM) has a history of more than 2000 years. Modern clinical trials and experimental researches of TCM have been conducted for decades and provided support for the application of TCM in the prevention and treatment of ischemic heart disease (IHD). However the level of evidence and the proper application of TCM were still barely satisfactory.Methods: In this study, we divided IHD into 5 different stages, including stable angina, unstable angina, acute myocardial infarction, post myocardial infarction and chronic heart failure. Then we systematically reviewed and meta-analyzed the existing RCTs on both clinical manifestations and objective indicators, in these 5 aspects.Results: The results indicate that TCM can both improve the clinical manifestations and ameliorate the objective parameters in different courses of IHD. Some of the improvements lead to potential long-term benefits.Conclusions: TCM is effective on CVD in different stages of diseases, both in improving clinical manifestations and objective indicators. To acquire more solid and comprehensive evidence of TCM in treating CVD, more rigorously designed RCTs with longer follow-up duration are warranted.

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“…Those molecules have been used separately or as a mixture to cure or prevent cancer, cardiovascular disease, and neurodegenerative disease, among others [1,2]. Among natural compounds, Traditional Chinese Medicine (TCM) has the characteristics of low toxicity, multiple targets, and integrity, which can be regulated by the machinery of the body immune function, inhibit the formation of tumor tissue neovascularization, promote the death of tumor cells, and reduce the effect of tumor cell resistance to achieve antitumor properties, in the prevention and treatment of cancer prescription surface which have certain advantages [3][4][5]. Among TCM, Schisandra chinensis has been used for thousands of years to prevent memory deficiency [6].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Schisandrin B and Its Biological Properties

Nasser

Zhu

Chen

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nature is a vast source of bioactive molecules and has provided an active and efficient reservoir for drug discovery. Among natural compounds, one of the most promising is Schisandrin B (Sch B), isolated from Schisandra chinensis, which was documented to possess diversified pharmacokinetic propriety, among them antioxidant, anti-inflammation, cardioprotection, and neuroprotection. Due to its large biological properties, Sch B was recorded to be a potent cure for several diseases by targeting several signaling pathways. This review is aimed at emphasizing the recent data on the biological properties of Sch B among the molecular mechanism of this drug on tumoral, cardiac, and neural diseases. The data suggest that the antitumor activities of Sch B were mainly through apoptosis and cell cycle arrest at the diver’s stage. It is reported that Sch B could be used as effective chemotherapy, neuroprotection, and cardioprotection since it possesses a spectrum of biological activities; however, further investigations on the mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural drug candidate.

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Traditional Chinese Medicine for Cardiovascular Disease: Evidence and Potential Mechanisms

Cited by 56 publications

References 1 publication

Tongguan capsule‐derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts

Tongguan capsule‐derived herb reduces susceptibility to atrial fibrillation by inhibiting left atrial fibrosis via modulating cardiac fibroblasts

Traditional Chinese medicine for ischemic heart disease: clinical manifestations and objective indicators

A Comprehensive Review on Schisandrin B and Its Biological Properties

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