Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

Fan, Yiting; Yang, Zhihua; Wang, Lin; Liu, Yangxi; Song, Yinglin; Yu, Li; Wang, Xianliang; Zhao, Zhiqiang; Mao, Jingyuan

doi:10.3389/fphar.2023.1154167

Cited by 7 publications

(4 citation statements)

References 78 publications

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“…Another study in which elderly patients were included was carried out in China, where lower concentrations of VD were correlated with an enhanced risk of HFpEF. The findings of this study signified that VDD may be an important risk determinant regarding HFpEF [122]. The exact mechanisms through which VDD could play a part in HFpEF development are not fully understood.…”

Section: Heart Failure With Preserved Ejection Fraction (Hfpef)mentioning

confidence: 77%

Vitamin D and Cardiovascular Diseases: An Update

Haider,

Ghafoor,

Hassan

et al. 2023

Cureus

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Vitamin D is a vital nutrient that plays a significant part in several physiological processes within the human body, including calcium metabolism, bone health, immune function, and cell growth and differentiation. It is obtained mainly through exposure to sunlight but can be acquired from certain foods and supplements as well. Vitamin D deficiency (VDD) could be the risk factor for cardiovascular diseases (CVDs), such as heart disease and stroke. In blood vitamin D low levels have been linked with an enhanced risk of developing CVDs. However, it is unclear whether vitamin D levels are the leading cause or consequence of these conditions. While some studies highlight that taking vitamin D supplements could decrease the risk of CVD; however, more research is required to better understand the association between vitamin D and cardiovascular health. In this review, we aimed to summarize the currently available evidence supporting the association between vitamin D and CVDs and anesthesia considerations.

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Section: Heart Failure With Preserved Ejection Fraction (Hfpef)mentioning

confidence: 77%

Vitamin D and Cardiovascular Diseases: An Update

Haider,

Ghafoor,

Hassan

et al. 2023

Cureus

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“…HFpEF is associated with substantial morbidity and mortality, and modern medicine offers less effective treatment ( 83 ). Various CTPMs have shown good efficacy in the context of HFpEF, but the similarities and differences in their functionality are not clear ( 84 ). Therefore, selecting the most suitable CTPMs for patients has become an important clinical problem that needs to be solved.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reviews have reported that various TCM preparations, including decoctions, powders, tablets, capsules, and others, have shown positive therapeutic effects on HFpEF ( 84 , 86 ). However, these reviews have described these effects without quantitative analysis.…”

Section: Discussionmentioning

confidence: 99%

“…A comprehensive analysis of all outcome indicators revealed that QSYQDP + CWM and SXBXP + CWM may be the most favorable treatment options for HFpEF. Previous reviews have reported that various TCM preparations, including decoctions, powders, tablets, capsules, and others, have shown positive therapeutic effects on HFpEF (84,86). However, these reviews have described these effects without quantitative analysis.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Chinese traditional patent medicines for heart failure with preserved ejection fraction: a Bayesian network meta-analysis of 64 randomized controlled trials

Guo,

Zhu,

et al. 2023

Front. Cardiovasc. Med.

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BackgroundHeart failure with preserved ejection fraction (HFpEF) is associated with substantial morbidity and mortality, and modern medicine offers less effective treatment for HFpEF. Much evidence shows that Chinese traditional patent medicines (CTPMs) have good efficacy for HFpEF, but the advantages and disadvantages of different CTPMs for HFpEF are still unclear. This study used network meta-analysis (NMA) to compare clinical efficacies of different CTPMs for HFpEF.MethodsRandomized controlled trials (RCTs) of CTPMs for treating HFpEF were searched in seven Chinese and English databases from inception to September 2023: China National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biology Medicine, PubMed, Cochrane Library, and Embase. Two researchers independently screened the literature, extracted data, and evaluated the quality of the included studies. The GeMTC package in R (version 4.1.2) was used to perform Bayesian NMA.ResultsA total of 64 RCTs were included, involving six CTPMs and 6,238 patients. The six CTPMs were Qili Qiangxin capsule (QLQXC), Qishen Yiqi dropping pill (QSYQDP), Yixinshu capsule (YXSC), Yangxinshi tablet (YXST), Shexiang Baoxin Pill (SXBXP), and Tongxinluo capsule (TXLC). Conventional Western medicine (CWM) treatment was given to the control group, and CWM treatment combined with CTPM treatment was given to the experimental group. The results indicated that CPTMs + CWM were all superior to CWM alone; SXBXP + CWM had the best efficacies in improving the New York Heart Association cardiac functional classification efficiency; TXLC + CWM was best at improving the ratio of early diastolic mitral inflow velocity to late diastolic mitral inflow velocity (E/A); QSYQDP + CWM was best at reducing N-terminal pro-B type natriuretic peptide (NT-proBNP); and QSYQDP + CWM was best at improving the 6-min walking test. In terms of safety, there was no signiﬁcant difference between CTPMs + CWM and CWM.ConclusionCompared with CWM alone, CTPMs + CWM combinations have certain advantages and good safety in the treatment of HFpEF. QSYQDP + CWM and SXBXP + CWM may be the potential optimal integrative medicine-based treatments for HFpEF. Given the limitations of this study, further high-quality, multicenter, large sample, randomized, and double-blind studies are needed to confirm the current results.Systematic Review Registrationidentifier, CRD42022303938.

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Untargeted Profiling of Shenfu Qiangxin Pills Based on High‐Resolution Mass Spectrometry and Absolute Quantitation of Multiple Components Using Parallel Reaction Monitoring

Gao,

Liang,

Zhang

et al. 2024

J of Separation Science

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Shenfu Qiangxin (SFQX) pills are proprietary traditional Chinese medicine used for the treatment of chronic heart failure with significant clinical effects. However, the systematic identification and quantification of complexed components in SFQX have not been reported yet. In this work, a reliable and comprehensive method for a rapid identification of chemical components was developed by data dependent acquisition using ultra performance liquid chromatography coupled with high‐resolution mass spectrometry (UHPLC‐Q Exactive‐Orbitrap‐MS). A total of 104 compounds mainly including flavonoids, saponins, alkaloids, anthraquinones, coumarins, and phenolic acids were identified through database searching. The identified compounds were further ascribed to herb species in SFQX pills, such as Ginseng Radis et Rhizoma, Aconiti Lateralis Radix Praeparata (processed), Mori Cortex, Lepidii Semen, Rhei Radix et Rhizoma, and Polyporus. Thirty‐two representative compounds were elaborated with cleavage pathways and characteristic fragments in MS/MS spectrum of commercially available standards. A quantification method based on parallel reaction monitoring technique was established, and absolute quantification of 28 components in SFQX pills was then carried out. This work constitutes a basis and methodological reference for the quality control, consistency evaluation, and standardization of similar proprietary Chinese medicines.

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Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

Cited by 7 publications

References 78 publications

Vitamin D and Cardiovascular Diseases: An Update

Vitamin D and Cardiovascular Diseases: An Update

Efficacy of Chinese traditional patent medicines for heart failure with preserved ejection fraction: a Bayesian network meta-analysis of 64 randomized controlled trials

Untargeted Profiling of Shenfu Qiangxin Pills Based on High‐Resolution Mass Spectrometry and Absolute Quantitation of Multiple Components Using Parallel Reaction Monitoring

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