Traditional Chinese medicine for treatment of sepsis and related multi-organ injury

Song, Yehao; Lin, Wei Chen; Zhu, Wen

doi:10.3389/fphar.2023.1003658

Cited by 12 publications

(5 citation statements)

References 154 publications

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“…The key inducing factor of sepsis-related multiple organ injury is the uncontrolled persistent inflammatory response, especially for patients with organ dysfunction in the past, which will aggravate the further deterioration of sepsis-related organ dysfunction [45] . When organ dysfunction occurs in hospitalized patients with sepsis, even mild organ injury can cause about 10% of the in-hospital mortality.…”

Section: Sepsis -Multiple Organsmentioning

confidence: 99%

Development of network pharmacology in sepsis treatment

Chen

2023

Preprint

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So far, sepsis is still a global disease and health problem facing mankind. Due to the complexity of the pathophysiology and pathogenesis of sepsis, the idea that a drug corresponds to a single target - a single disease is no longer suitable for the treatment of complex diseases such as sepsis. The application of network pharmacology to explore the signal network relationship between diseases, targets, and drugs has gradually become a new disease treatment methodology. This effective treatment for disease targets can improve the effectiveness and success of drug therapy, and it is possible to develop from the current treatment of symptoms of complex diseases to the real cure of complex diseases. This paper will discuss the application and discovery of network pharmacology in the treatment of sepsis, to provide a certain scientific theoretical basis for the subsequent basic and clinical research of sepsis treatment.

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Section: Sepsis -Multiple Organsmentioning

confidence: 99%

Development of network pharmacology in sepsis treatment

Chen

2023

Preprint

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“…This review summarizes several effective TCM methods for treating sepsis, including TCM compounds, herbal monomer extracts, and acupuncture. Among these, acupuncture is a promising non-pharmacological treatment that may be effective for sepsis [9] . It has been practiced in the clinic for over 2,000 years.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture targeting the immune system to alleviate sepsis

Fang,

Lan,

et al. 2024

Acupuncture and Herbal Medicine

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Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates. However, options for sepsis are still limited to general treatment in intensive care units (ICUs), and effective therapies that improve sepsis survival are required. Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation, susceptibility to infections, and death. Therefore, many investigators have focused on the potential benefits of immunomodulation therapy for sepsis. Electroacupuncture (EA) has been practiced in clinics for many years and has shown advantages in treating infectious diseases. Over the last few decades, our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments. We searched the literature regarding “CNKI, Wan Fang Data, VIP Database, PubMed, and Ingenta Connect” from 2010 to 2023, using the keywords "sepsis," "septic," and “electroacupuncture” and 336 sources were searched. Finally, we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on sepsis. In this review, we found that EA has clinical benefits in relieving septic inflammation, improving immune function, and attenuating related muti-organ injury through several mechanisms, such as activation of the cholinergic anti-inflammatory pathway (CAP), vagal-adrenal axis, inhibition of the nuclear factor Kappa-B (NF-κB) signaling pathway, signal transducers and activators of transcription (STAT) signaling pathway, and improvement of immune cell function. Therefore, EA may be a promising complementary therapy for sepsis treatment. We also expect these data will contribute to further studies on EA in sepsis.

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“…In recent years, Chinese medicine has proven to be safe and effective as a complementary or alternative therapy for sepsis (4). Curcuminoids are comprised of three components, including bisdemethoxycurcumin (10%-15%), demethoxycurcumin (20%-27%), and curcumin (60%-70%).…”

Section: Introductionmentioning

confidence: 99%

Research progress of curcumin in the treatment of sepsis

Tao,

Shen

2024

Shock

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Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. It is an important clinical problem in acute and critical care. In recent years, with the increasing research on the epidemiology, and pathogenesis, diagnostic and therapeutic strategies of sepsis, great progress has been made in clinical practice, but there is still a lack of specific and effective treatment plans. Curcuma longa, a leafy plant of the ginger family, which is a common and safe compound, has multiple pharmacological actions, including, but not limited to, scavenging of oxygen free radicals, attenuation of inflammatory response, and anti-fibrotic effects. Great progress has been made in the study of sepsis-associated rodent models and in vitro cellular models. However, the evidence of curcumin in the clinical management practice of sepsis is still insufficient; hence, it is very important to systematically summarize the study of curcumin and sepsis pathogenesis.

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Traditional Chinese medicine for treatment of sepsis and related multi-organ injury

Cited by 12 publications

References 154 publications

Development of network pharmacology in sepsis treatment

Development of network pharmacology in sepsis treatment

Electroacupuncture targeting the immune system to alleviate sepsis

Research progress of curcumin in the treatment of sepsis

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