Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis

Bu, Lan; Dai, Ou; Zhou, Fei; Liu, Fei; Chen, Jinfeng; Peng, Cheng; Xiong, Liang

doi:10.1016/j.biopha.2020.110855

Cited by 87 publications

(40 citation statements)

References 155 publications

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“…TCM extract is a kind of TCM product with a relatively clear pharmacodynamic material basis and strict quality standard, which is a novel product form in the international natural medicine market and can be widely used in natural health products ( Shen et al, 2017 ; Bu et al, 2020 ). At present, a variety of preclinical works on the anti-CRC effect of TCM extracts (water extract, ethanolic extract, chloroform extract, etc) have been reported.…”

Section: Antitumor Status Of Traditional Chinese Medicine and Its Clinical Trials On Colorectal Cancermentioning

confidence: 99%

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Sun

Zhang

et al. 2021

Front. Pharmacol.

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As an important part of complementary and alternative medicine, traditional Chinese medicine (TCM) has been applied to treat a host of diseases for centuries. Over the years, with the incidence rate of human colorectal cancer (CRC) increasing continuously and the advantage of TCM gradually becoming more prominent, the importance of TCM in both domestic and international fields is also growing with each passing day. However, the unknowability of active ingredients, effective substances, and the underlying mechanisms of TCM against this malignant tumor greatly restricts the translation degree of clinical products and the pace of precision medicine. In this review, based on the characteristics of TCM and the oral administration of most ingredients, we herein provide beneficial information for the clinical utilization of TCM in the prevention and treatment of CRC and retrospect the current preclinical studies on the related active ingredients, as well as put forward the research mode for the discovery of active ingredients and effective substances in TCM, to provide novel insights into the research and development of innovative agents from this conventional medicine for CRC treatment and assist the realization of precision medicine.

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Section: Antitumor Status Of Traditional Chinese Medicine and Its Clinical Trials On Colorectal Cancermentioning

confidence: 99%

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Sun

Zhang

et al. 2021

Front. Pharmacol.

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“…The origins of allopathic medicine are also rooted in the pharmacognosy of natural products, with at least 200 pharmaceuticals having been developed by extracting the active principles from their naturally occurring species especially those of plant origins. 5 The Tao-Hong-Si-Wu-Tang (THSWT) 6 and Wu Cao Si Wu Tang (SWT) 7,8 combinations are famous traditional Chinese herbal medicine formulae, which have traditionally been used in China for a variety of illnesses and maladies for about one thousand years. 4 As with many herbal remedies used in folklore, not all of the ingredients are well documented, and not all have been subjected to detailed scientifically controlled clinical trials that could prove or disprove the purported benefits.…”

Section: Introductionmentioning

confidence: 99%

“…), Tao Ren (Prunus persica (L.) Batsch. ), and Hong Hua (Carthamus tinctorius L), 6 while the SWT formula 7 consists of four herb units: Rx. Rehmanniea, Rx.…”

Section: Introductionmentioning

confidence: 99%

“…Both of the above formulas have long been employed clinically in TCM to promote blood circulation, to relieve women's irregular menses disorders, and have also been used to treat immunological disorders, migraine, mood disorders and cardiovascular diseases such as hypertension and angina. [6][7][8] Furthermore, because they have been reported to increase blood flow of the microcirculation the formula has been reported to provide beneficial effects in regulating diabetic neuropathies and remineralization of glucocorticoid-induced avascular necrosis of the femoral head. 9 In addition, THSWT has traditionally also been used as a folk remedy in the treatment of physical and mental fatigue in the southern part of China, and in recent animal studies has been shown to significantly improve physical endurance during exercise along with improvements in numerous biochemical parameters including exercise induced lactate accumulation, enhanced glycogen metabolism, and in improved nitrogen metabolism, thereby lending scientific credence to the actions claimed by folklore.…”

Section: Introductionmentioning

confidence: 99%

“…10 An especially important form of dosage in TCM is the preparation of a decoction, which is known to bring about a more positive clinical impact due to the boiling method used in its preparation. 7,8 The improved clinical effects of decoctions are thought to be due to the boiling method used in their preparation. The heat and moisture applied during the preparation of decoctions causes the plant fibers to swell and the combined heat and moisture facilitates the breakdown of the indigestible plant cell walls, thereby enabling a more effective extraction of the active principles from the plant sources.…”

Section: Introductionmentioning

confidence: 99%

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2021

AOWMC

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The tradition of Chinese Medicine (TCM) has been in use and development for thousands of years, where it has been applied in some form for the treatment of nearly every common illness. TCM is currently undergoing a resurgence in interest and in providing an adjunct to allopathic medical care virtually worldwide. TCM therapeutics may be administered in many forms from capsules, to powders, homogenates, tinctures and decoctions. Si Wu Tang, a derivative of the traditional Chinese including Formulas, is a combination of substances that may function in a synergistic manner to promote a calming effect and an amelioration of symptoms of hypertension. Such formulas are often used in TCM to treat or alleviate a wide range of the common illness and disorders of both Eastern and Western society. Reported beneficial effects include improvements in circulatory, cardiovascular, mood, endocrine metabolic and reproductive disorders. One such TCM formula commonly recommended is the Wu Cao Si Wu Tang [SWT]formula, used to treat the hypertension of obesity and a variety of other disorders. Hypertension is a key risk factor for cardiovascular morbidity and mortality and is a leading cause of end-stage renal disease; over 7 million US deaths per year may be directly attributed to pathophysiologic complications resulting from poor control of blood pressure. While numerous advances in the diagnosis and treatment of hypertension have had a major impact on decreasing the overall risks and an improved management of this chronic disease, a definitive cure for all causes of hypertension has remained elusive to date. To determine the comparative effectiveness of conventional Western treatment vs. drug free Traditional Oriental Therapy for hypertension, we reviewed the data from independent studies. Wu Cao Si Wu Tang was found to be as effective as allopathic medications in controlling blood pressure in a group of moderately hypertensive patients.

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Flavonoid Compounds in Hippophae rhamnoides L. Protect Endothelial Cells from Oxidative Damage Through the PI3K/AKT‐eNOS Pathway

Wang,

Zhang,

Zhang

et al. 2024

Chemistry & Biodiversity

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Sea buckthorn, a traditional medicinal plant, has been used for several years in China for the prevention and treatment of various diseases, a practice closely associated with its significant antioxidant activity. The aim of this study was to investigate the protective effects of sea buckthorn flavonoids on vascular endothelial cells in an oxidative stress environment. We isolated and extracted active compounds from sea buckthorn and investigated their impact on endothelial nitric oxide synthase (eNOS) activity through the PI3K/AKT‐eNOS signaling pathway through a combination of network pharmacology and cellular experiments, elucidating the regulatory effects of these compounds on endothelial cell functions. Three flavonoids, named Fr.4‐2‐1, Fr.4‐2‐2 and Fr.4‐2‐3, were obtained from sea buckthorn. The results of network pharmacology indicated that they might exert their effects by regulating the PI3K‐AKT signaling pathway. In vitro results showed that all three flavonoids were effective in alleviating the degree of oxidative stress in cells, among which Fr.4‐2‐1 exerted its antioxidant effects by modulating the PI3K/AKT‐eNOS pathway. Flavonoids in sea buckthorn can effectively inhibit oxidative stress‐induced cellular damage, preserving the integrity and functionality of endothelial cells, which is crucial for maintaining vascular health and function.

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Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis

Cited by 87 publications

References 155 publications

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Untitled

Flavonoid Compounds in Hippophae rhamnoides L. Protect Endothelial Cells from Oxidative Damage Through the PI3K/AKT‐eNOS Pathway

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