Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review

Wei, Zihao; Chen, Jing; Zuo, Fang; Guo, Julie; Sun, Xiaodong; Liu, Deming; Liu, Conghai

doi:10.1016/j.jep.2022.115748

Cited by 56 publications

(23 citation statements)

References 123 publications

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“…TCM has been practiced for thousands of years, and is widely used in cancer treatment as a mainstream form of alternative and complementary therapy in China due to its effectiveness, low toxicity, and limited adverse effects. [22][23][24] Matrine possesses the dual advantages of both chemotherapeutic agents and traditional CHs, and shows distinct benefits in preventing cancers. 8 For instance, Matrine-inhibited M2-like macrophage polarization to block the metastasis of lung cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Chang,

Li,

Huang

et al. 2023

Environmental Toxicology

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BackgroundMatrine has been identified to have anticancer activity in hepatocellular carcinoma (HCC). Circ_0055976 was highly expressed in HCC. Here, we investigated the function and relationship of Matrine and circ_0055976 in HCC tumorigenesis.MethodsCell proliferation and invasion were detected using Cell Counting Kit‐8, 5‐Ethynyl‐2′‐deoxyuridine (EdU), colony formation and transwell assays, respectively. Cell aerobic glycolysis was evaluated by detecting glucose consumption, lactate production, and the ratios of ATP/ADP. Levels of genes and proteins were detected by quantitative real‐time polymerase chain reaction and Western blotting. The target relationship between miR‐1179 and circ_0055976 or lactate dehydrogenase A (LDHA) was analyzed by dual‐luciferase reporter assay. The mouse xenograft model was established to conduct the in vivo assay.ResultsMatrine suppressed HCC cell proliferation, invasion and anaerobic glycolysis in vitro. Circ_0055976 was highly expressed in HCC tissues and cells, and was reduced by Matrine treatment. Moreover, overexpression of circ_0055976 reversed the anticancer effects of Matrine in HCC cells. Mechanistically, circ_0055976/miR‐1179/LDHA formed an axis. Circ_0055976 knockdown or miR‐1179 overexpression impaired HCC cell proliferation, invasion, and anaerobic glycolysis, which were reversed by miR‐1179 inhibition or LDHA overexpression. Meanwhile, forced expression of LDHA abolished the regulatory effects of Matrine on HCC cells. In the clinic, Matrine impeded HCC tumor growth in vivo, and this effect was boosted after circ_0055976 silencing.ConclusionMatrine suppressed HCC cell proliferation, invasion, and anaerobic glycolysis via circ_0055976/miR‐1179/LDHA axis, providing a new insight into the clinical application of Matrine in HCC treatment.

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Section: Discussionmentioning

confidence: 99%

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Chang,

Li,

Huang

et al. 2023

Environmental Toxicology

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“…Scutellarin and scutellarein are the natural oxyflavonoids obtained from Erigeron breviscapus ; they are naturally glycosylated, perform a wide range of functions and have a variety of medicinal properties [ 13 , 141 , 142 ]. The therapeutic properties are as follows: vasodilating, acting as an anticoagulant and being tumor suppressive.…”

Section: Regulation Of Autophagy By Scutellaria Fl...mentioning

confidence: 99%

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

Tuli

Bhushan

Kumar³

et al. 2023

Pharmaceuticals

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In parallel with a steady rise in cancer incidence worldwide, the scientific community is increasingly focused on finding novel, safer and more efficient modalities for managing this disease. Over the past decades, natural products have been described as a significant source of new structural leads for novel drug candidates. Scutellaria root is one of the most studied natural products because of its anticancer potential. Besides just describing the cytotoxic properties of plant constituents, their molecular mechanisms of action in different cancer types are equally important. Therefore, this review article focuses on the role of the Scutellaria flavones wogonin, baicalein, baicalin, scutellarein and scutellarin in regulating the autophagic machinery in diverse cancer models, highlighting these molecules as potential lead compounds for the fight against malignant neoplasms. The knowledge that autophagy can function as a dual-edged sword, acting in both a pro- and antitumorigenic manner, further complicates the issue, revealing an amazing property of flavonoids that behave either as anti- or proautophagic agents.

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“…In the research field of various diseases, TCM has an inestimable prospect. All kinds of traditional Chinese medicine not only have excellent performance in relieving symptoms but also play a huge role in curing diseases [6][7][8]. In the fight against the novel coronavirus disease 2019 (COVID- 19), traditional Chinese medicines have a remarkable effect on preventing infection and curing mild infections [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

TCM Prescription Generation via Knowledge Source Guidance Network Combined with Herbal Candidate Mechanism

Hou

Song

Zhao

et al. 2023

Computational and Mathematical Methods in Medicine

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Traditional Chinese medicine (TCM) prescriptions have made great contributions to the treatment of diseases and health preservation. To alleviate the shortage of TCM resources and improve the professionalism of automatically generated prescriptions, this paper deeply explores the connection between symptoms and herbs through deep learning technology, and realizes the automatic generation of TCM prescriptions. Particularly, this paper considers the significance of referring to similar underlying prescriptions as herbal candidates in the TCM prescribing process. Moreover, this paper incorporates the idea of referring to the potential guidance information of corresponding prescriptions when model extracts symptoms representations. To provide a reference for inexperienced young TCM doctors when they prescribe, this paper proposes a dual-branch guidance strategy combined with candidate attention model (DGSCAM) to automatically generate TCM prescriptions based on symptoms text. The format of the data used this paper is the “symptoms-prescription” data pair. The specific method is as follows. First, DGSCAM realizes the extraction of key information of prescription-guided symptoms through a dual-branch network. Then, herbal candidates in the form of prescriptions that can treat symptoms are proposed in view of the compatibility knowledge of TCM prescriptions. To our knowledge, this is the first attempt to use prescriptions as herbal candidates in the prescription generation process. We conduct extensive experiments on a mixed public and clinical dataset, achieving 37.39% precision, 25.04% recall, and 29.99% F1 score, with an average doctor score of 7.7 out of 10. The experimental results show that our proposed model is valid and can generate more specialized TCM prescriptions than the baseline models. The DGSCAM developed by us has broad application scenarios and greatly promotes the research on intelligent TCM prescribing.

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Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review

Cited by 56 publications

References 123 publications

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR‐1179/lactate dehydrogenase A axis

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

TCM Prescription Generation via Knowledge Source Guidance Network Combined with Herbal Candidate Mechanism

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