Traditional Chinese Medicine in the Treatment of Diabetes

Covington, Maggie B.

doi:10.2337/diaspect.14.3.154

Cited by 95 publications

(74 citation statements)

References 5 publications

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“…Diabetes is a major health problem worldwide along with its associated complications (Zimmet et al, 1997) and this could be linked to changes in the dietary patterns in both developing and developed countries. The prevalence of type II diabetes is growing at an exponential rate (Zimmet and Lefebvre, 1996) and a lot of attention is been given to natural products for the management of the disease (Covington, 2001).…”

Section: Introductionmentioning

confidence: 99%

Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties

Ademosun¹

2013

Afr. J. Pharm. Pharmacol.

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This study sought to compare the antioxidant properties [1,1-diphenyl-2 picrylhydrazyl (DPPH) and hydroxyl (OH) radicals scavenging abilities] and inhibition of Fe 2+ -induced lipid peroxidation and two key enzymes relevant to type-2 diabetes (α-amylase and α-glucosidase) of snake tomato (Trichosanthes cucumerina) with two tomato varieties [Lycopersicon esculentum Mill. var. esculentum (ESC) and Lycopersicon esculentum Mill. var. cerasiforme (CER)]. Snake tomato (0.84 mg/g) and CER (0.87 mg/g) had significantly (P < 0.05) higher total phenolic content than ESC (0.27 mg/g). However, CER had the highest total flavonoid content of 0.48 mg/g, compared to snake tomato (0.27 mg/g) and ESC (0.15 mg/g). In consonance with the phenolic content, CER and snake tomato had higher DPPH and OH radicals scavenging abilities than ESC. The inhibition of Fe 2+ induced malondialdehyde (MDA) production in rats pancreas revealed that snake tomato had significantly lower inhibitory effect than CER. Furthermore, snake tomato and CER showed stronger inhibition of α-glucosidase [snake tomato (EC 50 = 1.65 mg/ml), CER (EC 50 = 1.32 mg/ml)] than α-amylase [snake tomato (EC 50 = 2.15 mg/ml), CER (EC 50 = 2.39 mg/ml)] activity. The antioxidant properties of snake tomato favourably compared with the cultivars of tomatoes, and its stronger inhibition of α-glucosidase activity than α-amylase activities suggests that snake tomato could be an alternative or complement to the use of lycopersicon tomatoes.

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Section: Introductionmentioning

confidence: 99%

Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties

Ademosun¹

2013

Afr. J. Pharm. Pharmacol.

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“…In view of TCM, diabetes is referred as Xiao Ke which is a syndrome of "wasting and thirsting" (Duan, 2008). The disease is described as the constitutional deficiency of yin of the kidney and lung and associated with the internal heat that consumes fluids, and thus causes wasting and thirst (Covington, 2001;Duan, 2008). There were 13 traditional herbal formulations for treating Xiao Ke according to the Yellow Emperor's Inner Canon, and later on derived into hundreds of prescriptions to aim at different symptoms of diabetes (Duan, 2008;Li et al, 2004).…”

Section: The Validation Of Holistic Application Of Herbal Formulationsmentioning

confidence: 99%

“…Upon identifying the disease pattern, a treatment plan, normally using herbal medicine and/or acupuncture, can be determined to rebalance the patient's inner yin and yang energy, and thus treating the root of the illness. Herbs may be prescribed individually or as part of a formula, of which formula are polyherbals including four typical components ( Table 2) that promote the effective use of herbs (Covington, 2001). The ultimate aim of Chinese healing is to preserve or restore the healthy equilibrium of the body to adapt to the living environment.…”

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confidence: 99%

Traditional Chinese Herbal Medicine – East Meets West in Validation and Therapeutic Application

Yuen¹,

Tse²,

Yung³

2012

Recent Advances in Theories and Practice of Chinese Medicine

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“…Qi is the driving force of life activities and Yin is the material basis of life activities (7). Damage of Qi is more common in early DN (8), and as the disease progresses, DN gradually causes the damage of Yin (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of ‘Spleen-kidney-care’ Yiqi Huayu and Jiangzhuo traditional Chinese medicine for the treatment of patients with diabetic nephropathy

Liu¹,

Zheng²,

Li³

2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the effect of the traditional Chinese medicine (TCM), ʻSpleen-kidney-careʼ Yiqi Huayu and Jiangzhuo decoction (SKC-YJ), as an adjuvant therapy in diabetic nephropathy (DN) treatment. In total, 72 patients with DN were randomly divided into control (n=54) and experimental (n=18) groups, with the latter administered SKC-YJ treatment. Indicators for determining the condition of the patients included the levels of proteinuria, blood glucose, glycosylated hemoglobin, blood lipids, blood viscosity and C-reactive protein, which were used to analyze the treatment protocols for DN. Following SKC-YJ treatment, the urinary albumin excretion rate, fasting blood glucose, 2 h-postprandial blood glucose, glycosylated hemoglobin, triglyceride, total cholesterol, blood viscosity, fibrinogen and C-reactive protein levels were detected in the two groups, and were all demonstrated to decrease significantly following treatment with SKC-YJ. Furthermore, the results revealed that SKC-YJ treatment exhibited no significant side-effects on the blood, liver and renal functions or gastrointestinal reactions. By contrast, SKC-YJ improved the symptoms of nausea, vomiting and diarrhea in the patients with DN, while showing no allergic reaction during the observation period. Therefore, SKC-YJ treatment was shown to significantly improve the clinical efficacy of DN treatment, illustrating novel roles for TCM in DN treatment. IntroductionAn increasing number of studies have revealed that the incidence of diabetes is based on the relative or absolute deficiency of insulin secretion from islet β-cells, which is caused by high levels of blood glucose (1-3). Diabetes is characterized by chronic, systemic metabolic disorders, while diabetic nephropathy (DN) is a systemic complication of diabetes. DN is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli (4) and is characterized by nephrotic syndrome and diffuse glomerulosclerosis. DN is one of the most serious, chronic complications of diabetes, seriously affecting the life of patients, and in certain cases, resulting in mortality (5).According to traditional Chinese medicine (TCM) syndrome differentiation typing, DN is classified as a variety of types, including 'Thirsty', 'Consumption' and 'Edema' (6). Specifically, DN is associated with congenital deficiency, diet, emotional disorders, excessive labor and fever. Currently, TCM considers the pathogenesis of DN to be involved in spleen and kidney deficiency. Qi is the driving force of life activities and Yin is the material basis of life activities (7). Damage of Qi is more common in early DN (8), and as the disease progresses, DN gradually causes the damage of Yin (8-10).Disease of the islet β-cells is closely associated with the spleen (11). Modern medicine and TCM considers the kidney to be associated with the nervous, endocrine, reproductive, exercise, breathing, digestion, water metabolism, blood and immune systems, as well as other abnormal physi...

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Traditional Chinese Medicine in the Treatment of Diabetes

Cited by 95 publications

References 5 publications

Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties

Antioxidative properties and inhibition of key enzymes linked to type-2 diabetes by snake tomato (Tricosanthes cucumerina) and two tomato (Lycopersicon esculentum) varieties

Traditional Chinese Herbal Medicine – East Meets West in Validation and Therapeutic Application

Clinical efficacy of ‘Spleen-kidney-care’ Yiqi Huayu and Jiangzhuo traditional Chinese medicine for the treatment of patients with diabetic nephropathy

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