Traditional Chinese Medicine Injections in the Treatment of Diabetic Foot: A Systematic Review and Meta‐Analysis

Tan, Lizi; Shi, Qingyang; Liu, Chunxiang; Zhang, Junhua; Wang, Hui; Zhai, Jing

doi:10.1155/2018/4730896

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…Thus, there is an utmost need for the development of new therapeutic agents that can exert multifunctional potential on the various phases of wound healing. A systematic review reported that therapeutic moieties of natural origin could be implicated in the management of impaired DFU [15]. Boswellia serrata Roxb.…”

Section: Wound Healing Potential Of the Standardized Extract Of Boswementioning

confidence: 99%

Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers

Pengzong

Xiong

et al. 2019

Planta Med

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The aim of the present study was to evaluate the wound healing potential and possible mechanism of action of the standardized extract of Boswellia serrata against the experimental model of diabetic foot ulcer. α-Boswellic acid was isolated from the standardized extract of B. serrata and characterized (HPLC, 1H-NMR, 13C-NMR, ESI-MS). Diabetes was induced in Sprague-Dawley rats by streptozotocin (55 mg/kg, i. p.), and wounds were created on the dorsal surface of the hind paw. B. serrata (100, 200, and 400 mg/kg, p. o.) was administered to the rats for 16 days. The HPLC analysis showed a single peak with a retention time of 12.51 min. The compound was identified with ESI-MS [M + Na]+ = 455.37 as α-boswellic acid. Treatment with B. serrata (200 and 400 mg/kg) significantly increased the rate of wound contraction via modulation of oxido-nitrosative stress and elevated the hydroxyproline level at the wound area. reverse transcription-PCR analysis revealed that streptozotocin-induced increases in TNF-α, interleukin-1β, interleukin-6, nuclear factor-kappa-light-chain-enhancer of activated B cells, and Bcl-2-associated X protein, and decreases in angiopoietin-1, Tie2, transforming growth factor beta 1, vascular endothelial growth factor, and collagen-1 mRNA expression were significantly inhibited by B. serrata. It also significantly reduced wound cellular necrosis as evaluated by flow cytometry using propidium iodide fluorescence intensity. Streptozotocin-induced histopathological alterations were also significantly ameliorated by B. serrata. In conclusion, standardized extracts of B. serrata exert its wound healing potential via orchestrating mechanisms, which include the inhibition of oxido-inflammatory markers (oxido-nitrosative stress, TNF-α, interleukins, and nuclear factor-kappa-light-chain-enhancer of activated B cells), increased collagen synthesis (hydroxyproline and collagen-1) and angiogenesis (Ang-1/Tie2), promoting growth factors (transforming growth factor beta 1 and vascular endothelial growth factor), and inhibition of apoptosis (Bcl-2-associated X protein) to accelerate wound healing in experimental delayed diabetic foot ulcer.

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Section: Wound Healing Potential Of the Standardized Extract Of Boswementioning

confidence: 99%

Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers

Pengzong

Xiong

et al. 2019

Planta Med

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“…Previous study found that a group of traditional Chinese medicine (TCM) ( e.g. , herbal medicine foot bath decoction[ 5 ], TCM injections[ 6 , 7 ], Chinese herbal medicine ulcer oil[ 8 ], moxibustion[ 9 ], Astragali Radix and Rehmanniae Radix Mixture[ 10 ], the peptide compounds of Wuguchong[ 11 ], Astragali Radix and Rehmanniae Radix[ 12 , 13 ]) played an important role in the treatment of the disease. Some study also found that interventional radiology plays a crucial role in the treatment of diabetic foot disease[ 14 ].…”

Section: To the Editormentioning

confidence: 99%

“…In recent years, most diabetic foot patients in China are adopting TCM and western medicine[ 5 , 15 ]. A series of systematic review articles showed that TCM can increase the clinical effective rate of conventional therapies by 27%[ 6 ], regulate the signaling pathways to promote diabetic wound healing[ 16 ]. An experiment on albino Wistar rats found that Astragali Radix and Rehmanniae Radix in the ratio of 2:1 significantly enhance the circulating CD34+/VEGFR2+/CD45-EPCs levels in diabetic foot ulcer[ 17 ].…”

Section: To the Editormentioning

confidence: 99%

More studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot

Yan

et al. 2022

WJD

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Diabetes mellitus is a common global public health problem that can cause serious illness and premature death. Diabetic foot ulcer, one of the complications of diabetes, is a major cause of morbidity and mortality and is associated with many other devastating complications. Previous study found that a group of traditional Chinese medicine (TCM) can be used for treating diabetic foot ulcers. More and more attention is being paid to the use of Chinese medicine to heal diabetic feet. Under the guidance of relevant theories of traditional Chinese medicine, more studies are needed to reveal the key active components and related signal pathways of TCM in the treatment of diabetic foot ulcer. One clinical study explored the treatment of diabetic foot with infection combined moist exposed burn ointment with Jinhuang powder. However, large-scale multi-center, double blind, randomized, placebo-controlled clinical trials and animal studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot.

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“…Research on TCM for chronic non-communicable diseases has recently developed rapidly[ 40 ]. In particular, studies have reported that oral administration or injection of TCM herbal-based agents as an additional treatment to conventional therapies is beneficial to DFU healing[ 41 , 42 ]. Meanwhile, in recent years, complementary modalities have also demonstrated therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot

Liu¹,

Li²,

Guo³

et al. 2022

World J Diabetes

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Diabetes mellitus (DM) is a complex disease that often causes multiple systemic complications that have become a major international public health problem. Diabetic foot (DF) is one of the severe and frequent chronic complications of DM due to vascular lesions and neuropathy. DF ulcers (DFU) affect approximately 15% of people with DM and are the leading cause of death and disability. The prevalence and recurrence of DF are worrisome, and morbidity and mortality are also on the rise, which poses a substantial socioeconomic burden. Treating DF is difficult for clinicians and requires multidisciplinary cooperation, combining local and systemic therapy to reduce amputation and case-fatality rates. Traditional Chinese Medicine (TCM) has received extensive attention due to noticeable therapeutic effects and few adverse reactions. In recent years, research on DF treatment by TCM has been increasing, and further progress has been made. TCM includes oral medication, injectable preparations, and adjuvant therapy. This article reviews the relevant research on TCM-related adjuvant therapy for DF. We describe current progress in TCM in terms of external application, acupuncture, massage, acupoint injection, foot bath, fumigation, and moxibustion, as well as the mechanisms involved.

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Traditional Chinese Medicine Injections in the Treatment of Diabetic Foot: A Systematic Review and Meta‐Analysis

Cited by 8 publications

References 21 publications

Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers

Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers

More studies are necessary to establish the effectiveness of Jinhuang powder in the treatment of diabetic foot

Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot

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