Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

Ling, Xi; Zhang, Xiaoxuan; Nie, Min; Zhao, Yuanjin

doi:10.34133/research.0141

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…We employed a template-assisted layer-by-layer deposition and solidification technique to fabricate bilayer microneedles. , As shown in Figure A–C, fluorescence microscopy revealed bilayer MNs consisting of a SA layer (indicated in red) and a FK13-a1 layer (shown in green), confirming the bilayer structure of the SA/FK13-a1@GelMA MNs. Scanning electron microscopy (SEM) results, presented in Figure S2, displayed the conical structure of the microneedle array, characterized by a sharp tip, a height of 600 μm, and a base diameter of 300 μm.…”

Section: Resultsmentioning

confidence: 75%

pH- and Matrix Metalloproteinase-Responsive Multifunctional Bilayer Microneedles Platform for Treatment of Tinea Pedis

Yang,

Pan,

Tian

et al. 2024

ACS Biomater. Sci. Eng.

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Persistent foot odor and itchiness are common symptoms of tinea pedis, significantly disrupting the daily life of those affected. The cuticular barrier at the site of the tinea pedis is thickened, which impedes the effective penetration of antifungal agents. Additionally, fungi can migrate from the skin surface to deeper tissues, posing challenges in the current clinical treatment for tinea pedis. To effectively treat tinea pedis, we developed a platform of bilayer gelatin methacrylate (GelMA) microneedles (MNs) loaded with salicylic acid (SA) and FK13-a1 (SA/FK13-a1@GelMA MNs). SA/FK13-a1@GelMA MNs exhibit pH-and matrix metalloproteinase (MMP)-responsive properties for efficient drug delivery. The MNs are designed to deliver salicylic acid (SA) deep into the stratum corneum, softening the cuticle and creating microchannels. This process enables the antibacterial peptide FK13-a1 to penetrate through the stratum corneum barrier, facilitating intradermal diffusion and exerting antifungal and anti-inflammatory effects. In severe cases of tinea pedis, heightened local pH levels and MMP activity further accelerate drug release. Our research demonstrates that SA/FK13-a1@GelMA MNs are highly effective against Trichophyton mentagrophytes, Trichophyton rubrum, and Candida albicans. They also reduced stratum corneum thickness, fungal burden, and inflammation in a guinea pig model of tinea pedis induced by T. mentagrophytes. Furthermore, it was discovered that SA/FK13-a1@GelMA MNs exhibit excellent biocompatibility. These findings suggest that SA/FK13-a1@GelMA MNs have significant potential for the clinical treatment of tinea pedis as well as other fungal skin disorders.

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Section: Resultsmentioning

confidence: 75%

pH- and Matrix Metalloproteinase-Responsive Multifunctional Bilayer Microneedles Platform for Treatment of Tinea Pedis

Yang,

Pan,

Tian

et al. 2024

ACS Biomater. Sci. Eng.

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“…Small vascular lesions and dysfunction of fibroblast cells can easily lead to skin fibrosis. To alleviate this condition, Luan et al [ 146 ] employed a template-assisted layer-by-layer curing method to prepare photothermal-responsive micro-needles. The needle tips encapsulated triptolide and paeoniflorin (TP/Pae), while the needle bases encapsulated BP/TP/Pae.…”

Section: Bp-based Composite Biomaterials For Tissue Repairmentioning

confidence: 99%

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Qi,

Zhang,

Wang

et al. 2024

Pharmaceuticals

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Black Phosphorus (BP) is a new semiconductor material with excellent biocompatibility, degradability, and optical and electrophysical properties. A growing number of studies show that BP has high potential applications in the biomedical field. This article aims to systematically review the research progress of BP composite medical materials in the field of tissue engineering, mining BP in bone regeneration, skin repair, nerve repair, inflammation, treatment methods, and the application mechanism. Furthermore, the paper discusses the shortcomings and future recommendations related to the development of BP. These shortcomings include stability, photothermal conversion capacity, preparation process, and other related issues. However, despite these challenges, the utilization of BP-based medical materials holds immense promise in revolutionizing the field of tissue repair.

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“…Despite these advancements, current research on MNs for skin diseases still faces challenges [ 16 ]. One major obstacle lies in the uniform structure of most current MNs, which significantly hinders temporally and spatially controlled release of medications [ 17 , 18 ]. In addition, the effectiveness of conventional small-molecule medications remains unsatisfactory [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine Integrated Multifunctional Responsive Core–Shell Microneedles for Dermatosis Treatment

Luan,

Zhang,

Luan

et al. 2024

Research

Self Cite

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Microneedles have demonstrated value in targeted treatment of dermatosis. Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects. Here, we present innovative shell–core microneedles with light-pH dual responsiveness for spatiotemporal sequential release of multiple Chinese herb drugs to treat scleroderma. By using a stepwise template-assisted method, we effectively prepare a hydrogel-based core layer containing polydopamine-MXene (P-MXene) loaded with triptolide (TP), and a shell layer composed of polyvinyl alcohol (PVA) encapsulating paeoniflorin (Pae). P-MXene can adsorb the sparingly soluble TP to ensure its encapsulation efficiency and contribute to the synergistic photothermal effect benefitting from its excellent photothermal conversion ability. Besides, PVA can rapidly dissolve upon microneedle piercing into the skin and quickly release the anti-inflammatory and detoxifying Pae, establishing a favorable low-acid subcutaneous environment. In response to pH changes and near-infrared effects, TP is sustainably released from P-MXene and delivered through the swollen pores of the hydrogel. On the basis of these characteristics, we demonstrate that these microneedles could effectively reduce profibrotic key cytokines interleukin-1β and transforming growth factor-β, thereby reducing collagen deposition and decreasing epidermal thickness, ameliorating skin fibrosis and capillary lesion in scleroderma mouse models. These findings highlight the important clinical potential of these microneedles in the treatment of skin diseases.

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Traditional Chinese Medicine Integrated Responsive Microneedles for Systemic Sclerosis Treatment

Cited by 6 publications

References 54 publications

pH- and Matrix Metalloproteinase-Responsive Multifunctional Bilayer Microneedles Platform for Treatment of Tinea Pedis

pH- and Matrix Metalloproteinase-Responsive Multifunctional Bilayer Microneedles Platform for Treatment of Tinea Pedis

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Traditional Chinese Medicine Integrated Multifunctional Responsive Core–Shell Microneedles for Dermatosis Treatment

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