Traditional Chinese medicine on treating chronic prostatitis/chronic pelvic pain syndrome

Abstract

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urinary system disease in the male population. Recent studies have shown that traditional Chinese medicine (TCM) can alleviate the pain caused by CP/CPPS to a certain extent and improve the quality of life of patients. In this systematic review, we aim to evaluate the effectiveness and safety of TCM for chronic prostatitis/chronic pelvic pain syndrome. Methods and analysis: We will search for PubMed, Cochrane Library, AMED, EMbase, WorldSciNet; Nature, Science online and China Journal Full-text Database (CNKI), China Biomedical Literature CD-ROM Database (CBM), and related randomized controlled trials included in the China Resources Database. The time is limited from the construction of the library to May 2019. The quality of the included randomized controlled trials (RCTs) will be evaluated with the risk of bias (ROB) tool and evidence will be evaluated by Grading of Recommendations Assessment Development and Evaluation (GRADE). STATA 13.0 and Revman 5.3 will be used to perform a systematic review and meta-analysis to synthesize direct and indirect evidence. Ethics and dissemination: This systematic review will evaluate the efficacy and safety of TCM for treating chronic prostatitis/chronic pelvic pain syndrome. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process trial. Trial registration number: PROSPERO CRD42019131527

The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b

“… 12 IL-2 is a regulatory growth factor that contributes to increased PGE-2 levels upon prostatitis, leading to microvasculature dilation, increased vascular permeability, and tissue edema. 13 MIP-2 and MIP-1α are chemotactic agents that recruit macrophages, lymphocytes and neutrophils to inflammatory sites. 14 Previous studies have shown that patients with chronic prostatitis have higher concentrations of MIP-2 and MIP-1α in their prostatic fluid, and that the levels of these cytokines are positively correlated with the severity of chronic prostatitis.…”

Prostatitis No.1 traditional chinese medicine significantly exhibited anti-inflammation role on prostatitis through miR-205-5p/YES1

“…Traditional Chinese medicine (TCM) has been widely used in clinical trials of prostatitis in recent years (8). According to TCM, the cause of prostatitis is mainly in the kidney.…”

Dihydroartemisinin Promoted Bone Marrow Mesenchymal Stem Cell Homing and Suppressed Inflammation and Oxidative Stress against Prostate Injury in Chronic Bacterial Prostatitis Mice Model

“…However, the treatment effects of these methods are not very satisfactory. Due to the multitargeted therapy and fewer side effects of traditional Chinese medicines (TCMs), there are more and more research studies that have focused on the prevention and treatment of CP with TCM [ 3 ]. Many TCM compound preparations and their active components such as Abacopteris penangiana [ 4 ], Bazhengsan [ 5 ], and flavonoids [ 6 ] were effective in the treatment of CP.…”