Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

Gao, Zhengrong; Feng, Yun‐Zhi; Zhao, Ya‐Qiong; Zhao, Jie; Zhou, Yinghui; Ye, Qin; Chen, Yun; Tan, Li; Zhang, Shaohui; Feng, Yao; Hu, Jiyi; Ou-Yang, Ze-Yue; Dusenge, Marie Aimee; Guo, Yue

doi:10.1186/s13020-022-00640-5

Cited by 19 publications

(15 citation statements)

References 187 publications

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“…Plant derived compounds have been included or added in the composition of orthopedic biomaterials (metallic, ceramic and polymeric matrix) in order to deliver the phytochemical substance at the bone site, leading to functionalized scaffolds with plant extracts applied in tissue engineering. A wide range of natural compounds have been proposed for incorporation within bone tissue engineering scaffolds in order to enhance bone growth, inhibit osteoclastic bone resorption, and prevent other bone-related complications [ 43 , 134 , 135 , 136 ]. Recently, an innovative concept has emerged in nanotechnology tissue engineering: combination and nanostructured scaffolds.…”

Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș

Miere

Filip

et al. 2023

Plants

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts); the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoprotegerin, osterix, RANKL, Runx2); and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds—such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others—presented a beneficial and stimulating effect in the bone regeneration process due to the pro-estrogenic activity, the antioxidant and the anti-inflammatory effect and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone-related pathologies envisaged through the incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș

Miere

Filip

et al. 2023

Plants

View full text Add to dashboard Cite

show abstract

“…Plant derived compounds have been included or added in the composition of orthopedic biomaterials (metallic, ceramic and polymeric matrix) in order to deliver the phytochemical substance at bone site leading to functionalized scaffolds with plant extracts applied in tissue engineering. A wide range of natural compounds have been proposed for incorporation within bone tissue engineering scaffolds in order to enhance bone growth, to inhibit osteoclastic bone resorption, and to prevent other bone-related complications [132,133]. Lately, an innovative concept has emerged from nanotechnology-tissue engineering combination and nanostructured scaffolds attracted a huge interest due to their promising results in improving the bone healing process.…”

Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș¹,

Miere²,

Filip³

et al. 2023

Preprint

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts), the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoportegerin, osterix, RANKL, Runx2) and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others presented a beneficial and stimulating effect in the bone regeneration process due to pro-estrogenic activity, antioxidant and anti-inflammatory effects and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone related pathologies envisaged by incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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“…Therefore, it is essential to create a medication that minimizes side effects while maintaining the medication's effectiveness. Chinese medicine is well known to play a signi cant role in the upkeep of health in Asian nations like China (Gao et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate

Cai

Song

Liu

et al. 2023

Preprint

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The purpose of this study was to investigate the mechanism by which resveratrol (Res) inhibits apoptosis and promotes proliferation and differentiation of preosteoblastic MC3T3-E1, laying the groundwork for the treatment of osteoporosis (OP). The TCMSP database was used to find the gene targets for Res. The GeneCards database yielded the gene targets for OP. Following the discovery of potential gene targets, GO, KEGG, and Reactome enrichment analysis were conducted. Verifying the major proteins involved in apoptosis can bind to Res using molecular docking. CCK8 measured the proliferative activity of mouse preosteoblasts in each group following Res intervention. Alkaline phosphatase staining (ALP) and alizarin red staining to measure the degree of osteogenic differentiation. RT-qPCR to determine the expression levels of Runx2 and OPG genes for osteogenic differentiation ability of cells. Western blot to measure the degree of apoptosis-related protein activity in each group following Res intervention. The biological processes investigated for GO of Res therapeutic OP involved in cytokine-mediated signaling pathway, negative regulation of apoptotic process, Aging, extrinsic apoptotic signaling pathway in absence of ligand, according to potential therapeutic target enrichment study. Apoptosis, FoxO signaling pathway, and TNF signaling pathway are the primary KEGG signaling pathways. Recactome pathways are primarily engaged in Programmed Cell Death, Apoptosis, Intrinsic Apoptotic Pathway, and Caspase activation via extrinsic apoptotic signaling pathways. This research established a new approach for Res treatment of OP by demonstrating how Res controls the apoptosis-related proteins TNF, IL6, and CASP3 to suppress osteoblast death and increase osteoclastogenesis.

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Traditional Chinese medicine promotes bone regeneration in bone tissue engineering

Cited by 19 publications

References 187 publications

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Resveratrol Prevents Apoptosis, allowing Preosteoblastic MC3T3-E1 cells to Proliferate and Differentiate

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