Traditional Chinese Medicine QPYF as Preventive Treatment for <i>Clostridium difficile</i> Associated Diarrhea in a Mouse Model

Guo, Yanan; Wang, Jun; Zhang, Haojun; Jia, Hao; Li, Ping; Liu, Xin-Zhu

doi:10.1155/2016/3759819

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…Therefore, the levels of inflammatory cytokines are evaluated in AAD, including TNF and IL-8. In our results, TCM can improve some inflammation factors, such as TNF and IL-8, while TCM makes no difference in hs-CRP, which is consistent with the results reported by Ya-Nan et al [ 55 ]. However, due to the limited study number, we cannot draw a definite conclusion about the results so far.…”

Section: Discussionsupporting

confidence: 93%

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

Sun

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Due to the limited treatment options in antibiotic-associated diarrhea (AAD) in children, more effective treatments should be explored. Traditional Chinese medicine (TCM) has a long history in China, which has produced a pretty effect in clinical practice. Many randomized clinical trials (RCTs) have explored the effect of traditional Chinese medicine on treating AAD in children. However, there has been no systematic review or meta-analysis on the impact of TCM on AAD in children. The aim of this study was to systematically review RCTs on the effect of TCM in children with AAD. Methods. RCTs in the past ten years on TCM for AAD in children were included. We searched Electronic databases as much as possible. This paper was registered in PROSPERO (CRD42022301034). Results. 26 studies were included in this systematic review. 25 studies reported the effects of TCM interventions on the total effective rate (RR = 1.20, CI 1.16 to 1.24; p < 0.001 ). 7 studies reported the effects of TCM interventions on the time to change the shape of feces (MD = −1.37, CI −1.67 to −1.07; p < 0.001 ). 17 studies reported the effects of TCM interventions (MD = −1.43, CI −1.71 to −1.15; p < 0.001 ). The pooled results showed that there were no significant differences between the two groups in CD3+, CD4+, CD8+, CD4 : CD8, time for bowel sounds to return to normal, hs-CRP, and IgM. There was a significant difference between the two groups in frequency of diarrhea on the third day after TCM intervention, vomiting improvement time, diamine oxidase, IL-8, TNF, IgA, IgG, and average hospital stay. Conclusions. TCM interventions combined with conventional therapy can improve the therapeutic effect of AAD in children. However, future studies are still needed for the low methodological quality.

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Section: Discussionsupporting

confidence: 93%

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

Sun

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…However, the increase of total eubacteria in the large intestine may be attributed to the increase of Lactobacillus genus , Enterobacteriaceae family , and Clostridium coccoides. Consistent with this notion, PR can be used as a preventive treatment for Clostridium difficile- associated diarrhea in a mouse model 71 . A lower abundance of Clostridium coccoides was detected in the caecum, while a higher abundance of the Enterococcus genus in the jejunum and caecum after PR intervention.…”

Section: Discussionmentioning

confidence: 73%

Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus

Zhang

et al. 2021

Sci Rep

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Puerarin has been reported to be an excellent antioxidant, anti-inflammatory and antimicrobial agent, but the potential effect of puerarin on porcine epidemic diarrhea virus (PEDV) is unclear. This study aimed to determine whether puerarin could alleviate intestinal injury in piglets infected with PEDV. A PEDV (Yunnan province strain) infection model was applied to 7-day-old piglets at 104.5 TCID50 (50% tissue culture infectious dose). Piglets were orally administered with puerarin at the dosage of 0.5 mg/kg body weight from day 5 to day 9. On day 9 of the trial, piglets were inoculated orally with PEDV. Three days later, jugular vein blood and intestinal samples were collected. Results showed puerarin reduced morbidity of piglets infected with PEDV. In addition, puerarin reduced the activities of aspartate aminotransferase and alkaline phosphatase, the ratio of serum aspartate aminotransferase to serum alanine aminotransferase, the number of white blood cells and neutrophils, and the plasma concentrations of interleukin-6, interleukin-8 and tumor necrosis factor-α, as well as protein abundances of heat shock protein-70 in PEDV-infected piglets. Moreover, puerarin increased D-xylose concentration but decreased intestinal fatty acid-binding protein concentration and diamine oxidase activity in the plasma of piglets infected with PEDV. Puerarin increased the activities of total superoxide dismutase, glutathione peroxidase and catalase, while decreasing the activities of myeloperoxidase and concentration of hydrogen peroxide in both the intestine and plasma of PEDV-infected piglets. Puerarin decreased mRNA levels of glutathione S-transferase omega 2 but increased the levels of nuclear factor erythroid 2-related factor 2. Furthermore, puerarin increased the abundance of total eubacteria (16S rRNA), Enterococcus genus, Lactobacillus genus and Enterobacteriaceae family in the intestine, but reduced the abundance of Clostridium coccoides in the caecum. These data indicate puerarin improved intestinal function in piglets infected by PEDV and may be a promising supplement for the prevention of PEDV infection.

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“…TCM has the characteristics of abundant resources, low cost, and few side effects, and it plays an important role in the Chinese medical system. Some studies have shown that herbal medicines have good efficacy against CDI [ 22 ]. The combination of TCM and antibiotics can prevent recurrent infections caused by antibiotic treatment [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated serum pharmacochemistry and metabolomics reveal potential effective components and mechanisms of Shengjiang Xiexin decoction in the treatment of Clostridium difficile infection

Cui¹,

Zhang²,

Zhang³

et al. 2023

Heliyon

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Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model

Cited by 10 publications

References 14 publications

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus

Integrated serum pharmacochemistry and metabolomics reveal potential effective components and mechanisms of Shengjiang Xiexin decoction in the treatment of Clostridium difficile infection

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