2020
DOI: 10.3389/fphar.2020.00497
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Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

Abstract: Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease characterized by memory loss and cognitive impairment. The major characteristics of AD are amyloid b plaques, apoptosis, autophagy dysfunction, neuroinflammation, oxidative stress, and mitochondrial dysfunction. These are mostly used as the significant indicators for selecting the effects of potential drugs. It is imperative to explain AD pathogenesis and realize productive treatments. Although the currently used chemical drugs for… Show more

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Cited by 75 publications
(50 citation statements)
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References 145 publications
(145 reference statements)
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“…Pharmacological studies have validated the efficacy of many bioactive compounds in traditional Chinese medicines used over thousands of years. [16] Recent published articles confirm the folkloric application of C. cicadae in arresting and treating several ailments. [10,11] CISP is indispensable in cancer chemotherapy, but its off-target behavior affecting vital organs in the body is worrisome to physicians and patients.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…Pharmacological studies have validated the efficacy of many bioactive compounds in traditional Chinese medicines used over thousands of years. [16] Recent published articles confirm the folkloric application of C. cicadae in arresting and treating several ailments. [10,11] CISP is indispensable in cancer chemotherapy, but its off-target behavior affecting vital organs in the body is worrisome to physicians and patients.…”
Section: Discussionmentioning
confidence: 93%
“…Pharmacological studies have validated the efficacy of many bioactive compounds in traditional Chinese medicines used over thousands of years [16] . Recent published articles confirm the folkloric application of C. cicadae in arresting and treating several ailments [10,11] .…”
Section: Discussionmentioning
confidence: 95%
“…In order to reduce oxidative damage in cardiovascular tissue, an increasing number of medicinal plants are used as natural antioxidants in the clinic [ 32 ]. Active components with antioxidant activity can be isolated from various medicinal plants [ 33 , 34 ]. Examples include phenols, flavonoids, and polysaccharides from traditional Chinese herbal medicine.…”
Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning
confidence: 99%
“…Traditional Chinese medicine (TCM) has been established for thousands of years in China’s medical system ( Chen et al, 2020b ). It has the characteristics of overall vision, syndrome differentiation, and treatment, and has unique advantages in the prevention, treatment, rehabilitation, and health care of various diseases ( Liang et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%