Traditional Chinese Medicine Tongxinluo Improves Cardiac Function of Rats with Dilated Cardiomyopathy

Abstract

The study aimed at testing the hypothesis that tongxinluo capsule might exert its cardioprotective effect by preventing ventricular remodeling and improving coronary microvascular function in a rat model of doxorubicin-induced dilated cardiomyopathy (DCM). Rats that survived DCM induction were randomly divided into three groups to be given 1.5 g·kg−1·day−1 (TXL-H, n = 9) or 0.15 g·kg−1·day−1 (TXL-L, n = 10) of tongxinluo, or normal saline at the same volume (DCM-C, n = 10) intragastrically. Age matched normal rats treated with normal saline were used as normal controls (NOR-C, n = 9). After four weeks of treatment, the DCM-C, TXL-H, and TXL-L groups exhibited significant cardiac dysfunction, left ventricular remodeling, and coronary microvascular dysfunction, compared with the NOR-C rats. However, myocardial functional parameters were significantly improved and microvascular density (MVD) increased in the TXL-H group compared with the DCM-C group (all P < 0.01). Left ventricular remodeling was prevented. There were close linear relationships between CVF and LVEF (r = −0.683, P < 0.05), MVD and LVEF (r = 0.895, P < 0.05), and MVD and CVF (r = −0.798, P < 0.05). It was indicated that high-dose tongxinluo effectively improved cardiac function in rat model of DCM.

The differential effects of green tea on dose-dependent doxorubicin toxicity

“…In the study, the rats were treated with a cumulative dose of DOX, seven times (1.0 or 2.0 mg/kg), every week, to approach the schedule of the clinical conditions ( 17 ). No observed general toxic effect was at 1 mg/kg and general toxic effect without mortality was found at 2 mg/kg ( 49 , 57 ). However, a similar schedule using even 0.8 mg DOX/kg results in adverse cardiac effects at the histological, ultrastructural, and biochemical levels ( 15 ).…”

Przegląd piśmiennictwa

“…Chińscy autorzy, Shen i wsp. [1], przeprowadzili badanie na modelu zwierzęcym DCM indukowanej doksorubicyną w celu oceny potencjalnego wpływu kardioprotekcyjnego TXL. Badanie odbyło się zgodnie z obowiązującymi międzynarodowymi regulacjami dotyczącymi etyki badań doświadczalnych nad zwierzętami.…”

“…Na-tomiast dawka stosowana w grupie TXL-L (0,15 g/kg mc./ /d.) jest około 3-krotnie mniejsza od wspomnianej dawki klinicznej [1].…”

Exploring the Pharmacological Mechanism of the modified Chinese medicine formulas “Shenfu-Linguizhugan decoction” treating Dilated cardiomyopathy Based on Network Pharmacology

“…As one of the most popular models of complementary and alternative medicine in China, TCM is gradually accepted by non-Chinese people due to its apparent e cacy, abundant resources, and low toxicity, and is increasingly used in western countries [6,7]. In the clinical treatment of DCM, there are many proprietary Chinese medicines and TCM injections alone or as an adjuvant to conventional chemotherapy [8][9][10][11].…”