Traditional, complementary and alternative medicine in children constipation: a systematic review

Paknejad, Maryam Sadat; Motaharifard, Monireh Sadat; Barimani, Shahdis; Kabiri, Payam

doi:10.1007/s40199-019-00297-w

Cited by 24 publications

(16 citation statements)

References 67 publications

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“…Therefore, such studies about the efficacy and safety of CAM remedies will be of value (14,15). Herbal medicines are among the most commonly used alternative therapies for constipation in adults and children, and most studies have demonstrated their effectiveness in treating the condition; however, low-quality studies are frequent (11,16).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

et al. 2021

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Background: Constipation is a common disorder, and its management imposes a significant health burden. Integration of complementary and alternative medicine into the current health system may result in beneficial outcomes. Objective: This study aimed to evaluate the efficacy and safety of a Persian medicine preparation ("Jalinous" capsule) on functional constipation. "Jalinous" capsule is a combination of Rose (Rosa damascena), mastic (Pistacia lentiscus), Aloe vera (Aloe barbadensis), and turpeth (Ipomoea turpethum). Methods: From January to December 2019, 126 patients aged 18 - 50 with functional constipation according to Rome IV criteria referred to Imam Khomeini hospital's gastrointestinal disease clinic were blindly randomized into "Jalinous" capsule group and placebo group for four weeks. Both groups received psyllium indeed. The patients were followed up at weeks two and four of the treatment and four weeks after the termination of the intervention. Results: Although the frequency of defecation, percentage of incomplete defecation and evacuation, straining during defecation, using manual maneuver to facilitate evacuation and defecation time showed significant improvement in both groups (P < 0.001), improvements in the intervention group were significantly more than in control group (P < 0.001). At the end of the second and fourth weeks of taking the drug and four weeks after stopping the drugs, the patients in the intervention group reported less frequent hard stool form in comparison to the patients in the control group (P < 0.001). Their overall self-reported improvement in symptoms after the treatment was significantly higher than the patients in the placebo group (P < 0.001). Adverse effects were not serious and mostly were transient. Conclusion: "Jalinous" capsule is an effective and safe treatment for functional constipation in adults, but more studies are needed to make confident conclusions.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

et al. 2021

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“…Today, in the medical literature, more studies should be carried out to provide evidence of molecular biology for the use of CAM methods in individual diagnosis and intervention within the framework of the concept of "Individualized Medicine". 7 CAM methods used in reducing the symptoms of pregnancy-related constipation differ from one study to another, in terms of the type of the study, and the application method, measurement tools and assessment methods used in the study. This systematic review of 3 studies (2 on the use of herbal medicine and 1 on the use of foot reflexology) demonstrated that the methods used in these 3 studies were effective in reducing the symptoms of pregnancy-related constipation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the enlargement of the uterus, a decrease in the activities of daily living of the mother, stress, taking iron and calcium preparations, inadequate fluid consumption and changes in diet cause constipation more frequently during pregnancy. 1,[6][7][8] The review of the literature demonstrated that pregnancy-related constipation (both difficult defecation and the feeling of not being able to empty fully) is common in every trimester of pregnancy. [9][10][11] Among the pharmacological methods used for constipation are the use of stool softeners, prokinetic agents, osmotic agents and stimulant laxatives.…”

Section: Introductionmentioning

confidence: 99%

Complementary and Alternative Therapies for Pregnant Women Suffering from Constipation: A Systematic review

ŞOLT

Aksoy

2021

International Journal of Traditional and Complementary Medicine Research

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Background: Constipation is one of the most common gastrointestinal symptoms in pregnant women. Purpose: This study was aimed at determining the effects of complementary and alternative therapy methods on the symptoms of pregnancy-related constipation. Search strategy: The authors performed a systematic search according to PRISMA guidelines. The database Web of Science, Scopus, EMBASE, CENTRAL, national databases were screened to reach studies published from January 2010 to March 2020 with restriction to human studies in English or Turkish language. The quality of the studies included in the study was assessed with the measurement tool proposed in the JADAD, JBI, and Observational Open-Label Studies scales. Inclusion criteria: Electronic searches were conducted in PubMed using the keywords constipation "pregnancy" or pregnant woman and "acupuncture" or "acupressure" or "massage" or "herbal medicine" or "aromatherapy" or "music therapy" or "homeopathy" or "hypnosis" or "meditation" or "reflexology" or "moxibustion" or "ayurvedic Medicine" or "ayurveda" or "Traditional Iranian Medicine Data extraction and analysis: Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Findings: 14536 studies were selected and 706 studies were screened based on their titles and abstracts. Seventy-three studies were analyzed in detail to assess whether they were suitable. In order to find a larger number of original articles, of the studies in the reference lists of these studies, those found in the electronical environment were screened, but no studies were found to meet the inclusion criteria. Finally, 3 studies were included in the study. Conclusions:The results demonstrated that herbal medicine and foot reflexology reduced constipation complaints during pregnancy without any side effects. Because the number of studies conducted to investigate the efficacy and safety of different types of complementary and alternative medicine methods in pregnant women with constipation is very few, more studies should be carried out on the issue.

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“…Herbal medicine can be tested and tried to complement the shortcomings of the current western medical model. These naturally derived medicines are reported to provide a complete holistic approach, capable of targeting multiple organs and cellular sites [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Preclinical Studies to Evaluate the Gut Stimulatory Activity of Aloe Musabbar

Tandur

Inamdar

Orfali

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Constipation is a common functional gastrointestinal disorder. Medicines derived from nature are routinely used to treat it. The present study evaluates the gut stimulatory activity of Aloe musabbar (processed powder of Aloe vera) using in vitro and in vivo models for gut stimulatory activity. Materials and Methods. In vitro tests were conducted on isolated rat colon, guinea pig ileum, and rabbit jejunum, while in vivo study was performed using mice intestinal transit time. Aloe musabbar (A. musabbar) was tested at doses 0.2–200 mg/mL (in-vitro study) and 86.6 mg/kg (in vivo study). In vitro studies were done in the presence and absence of atropine sulphate (1 ng/ml). The results were statistically analyzed, and p < 0.05 was considered to indicate the significance. Results. A. musabbar exhibited dose-dependent increase in the smooth muscle contraction of isolated gut tissues. Presence of atropine minimized the contractile responses and shifted the dose-response curves towards the right-hand side. The intestinal transit time in mice was observed to be increased significantly ( p < 0.01 ) in A. musabbar-treated animals, when compared with normal animals. Conclusion. A mild smooth muscle contraction induced by A. musabbar suggests that it can stimulate intestinal bowel movement without causing spasms. The diminished responses in the presence of atropine indicated that the gut stimulatory activity could be mediated partially through parasympathetic innervations. More studies are needed to determine the precise mechanism of action including the specific active ingredient responsible for the gut stimulatory activity.

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Traditional, complementary and alternative medicine in children constipation: a systematic review

Cited by 24 publications

References 67 publications

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

The Efficacy of a Persian Medicine Formulation on Adult Functional Constipation: A Double-blinded Clinical Trial

Complementary and Alternative Therapies for Pregnant Women Suffering from Constipation: A Systematic review

Preclinical Studies to Evaluate the Gut Stimulatory Activity of Aloe Musabbar

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