Despite gaining focus, cardiovascular disease (CVD) remains the leading cause of death worldwide. Health promotion agencies have traditionally recommended diets that are low in fat in order to reduce CVD risk however, much debate remains about which dietary approaches are the most efficient for effective disease prevention. Common markers of CVD include elevated plasma triglycerides (TG) and low-density lipoprotein (LDL) cholesterol levels, as well as reduced high-density lipoprotein (HDL) cholesterol levels. While weight loss alone can significantly reduce markers of CVD, manipulating dietary macronutrient content contributes to the beneficial effects of weight loss and furthers the improvement of lipid profiles even without the alteration of total caloric intake. Considering the recent attention to diets that are low in carbohydrates rather than fat, it remains to be elucidated the beneficial effects of each diet type when establishing new recommendations for CVD prevention. This review aims to examine the effects of different macronutrient compositions on lipid markers, thus providing insight into the potential roles of various diet types in the targeted prevention against CVD.
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BackgroundCardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, accounting for approximately 30% of all deaths, as well as placing a significant financial burden on existing health care systems [1,2]. Research targeted at understanding the development and progression of CVD has maintained prominence over the years, however, much debate remains about which clinical approaches are most efficient for its prevention. Rather than using the more traditional approach of weight loss alone to lower the risk of CVD, scientists have begun focusing on nutritional composition as an effective intervention. Recently, research has been directed towards understanding different dietary compositions and their impact on lipid profiles and markers of CVD risk. Based on these trends, many organizations (such as the American Heart Association) are providing dietary guidelines that endorse the higher consumption of whole grains and complex carbohydrates, vegetables and low fat dairy products. Also recommended is the consumption of foods which are lower in fat content, suggesting lean meats such as poultry/fish over red meat, and unsaturated fats over saturated and the avoidance of trans-unsaturated fats [3,4]. While low-fat diets such as these are highly recommended for individuals at risk of developing cardiovascular complications, it has become unclear whether these diets in fact improve lipid profiles and lower risk of developing CVD.Common markers of CVD include elevated levels of triglycerides (TG), low-density lipoprotein (LDL) and cholesterol [5][6][7]. Decreases of 1 mmol/L in plasma TG and LDL cholesterol levels are associated with a 22.5% and 28% reduction in relative risk of CVD deaths and 29.5% and 26.6% decrease in relative risk of coronary heart disease events, respectively, in popula...