The Strong Black Woman Schema (SBWS) is a cultural expectation for Black women to unfailingly display signs of strength and caretaker qualities, while suppressing their emotions. Although this schema is a purported source of strength for Black women, quantitative explorations of its psychological impact have been limited. In the present study, we examined associations between endorsement of the SBWS and several indicators of mental health and resilience in Black women. We analyzed responses from 212 college-aged, Black women assessing psychological distress, suicidal behaviors, resilience, and SBWS endorsement. Findings indicated that endorsement of the SBWS was positively related to both psychological distress and self-reported suicidal behaviors. In addition, the SBWS’ link to suicidal behaviors was mediated by psychological distress. Lastly, results from moderated mediation analysis supported a buffering effect of resilience. That is, when resilience was high, the association between psychological distress and suicidal behaviors, as well as the conditional indirect effects of the SBWS, was lessened. Implications of these findings suggest that prevalent endorsement of SBWS within Black communities may be harmful to Black women’s mental health. We call for additional research and provide recommendations on how the media, mental health professionals, and community leaders can mitigate its negative effects.