Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

Zhang, Jing; Hu, Kaili; Di, Liuqing; Wang, Penglong; Liu, Zhidong; Zhang, Jinming; Yue, Pengfei; Song, Wantong; Zhang, Jingwei; Chen, Tongkai; Wang, Zuhua; Zhang, Yongtai; Wang, Xiaoying; Zhan, Changyou; Cheng, Yung‐Chi; Li, Xiang; Li, Quan; Fan, Jing‐Yu; Shen, Youqing; Han, Jing‐Yan; Qiao, Hongzhi

doi:10.1016/j.addr.2021.113964

Cited by 111 publications

(68 citation statements)

References 424 publications

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“…However, such compounds commonly have poor stability, a short half-life in the body, a high clearance rate (making it hard for small-molecule-drugs to take effect in lesion accumulation), and a low curative effect; However, some properties of natural drugs are not conducive to their direct transportation and absorption in the human body, such as poor water solubility and easy decomposition under exposure to light or high temperature, which greatly limit their development. 112 The simple modification of natural products has become an important part of supramolecular self-assembly systems, and their good biocompatibility also makes assemblies based on these compounds applicable to tissue engineering, drug delivery, cell imaging, and other life sciences. Compared with non-natural products, nanogels formed by self-assembly of natural small-molecule compounds not only have good self-healing properties, controllable gel properties, good safety, and continuous release but also realize cooperative disease treatment through bioactive natural products.…”

Section: Natural Small-molecule Self-assembled Nanotechnology Drug De...mentioning

confidence: 99%

Research progress on self-assembled nanodrug delivery systems

Li¹,

Yang²,

Gao³

et al. 2022

J. Mater. Chem. B

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Section: Natural Small-molecule Self-assembled Nanotechnology Drug De...mentioning

confidence: 99%

Research progress on self-assembled nanodrug delivery systems

Li¹,

Yang²,

Gao³

et al. 2022

J. Mater. Chem. B

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“…It is well known that plants have been consumed by humans for thousands of years as a source of daily necessities and food supply. Plants also have been applied in several fields, including infrastructure, papermaking, production of perfumes and spices as well as applications for the treatment and prophylaxis of various diseases [94]. Therefore, traditional herbal medicine can be expressed as the use of plants or herbs as remedies in medicine in the following forms of herbal materials, herbs, herbal preparations, and finished herbal products containing active ingredients derived from plants/plant materials, according to the definition of the WHO [94].…”

Section: Phytomedicine and Human Healthmentioning

confidence: 99%

“…Plants also have been applied in several fields, including infrastructure, papermaking, production of perfumes and spices as well as applications for the treatment and prophylaxis of various diseases [94]. Therefore, traditional herbal medicine can be expressed as the use of plants or herbs as remedies in medicine in the following forms of herbal materials, herbs, herbal preparations, and finished herbal products containing active ingredients derived from plants/plant materials, according to the definition of the WHO [94]. Nano-formulated herbal bioactive could be applied for treating many human diseases such as neurodegenerative diseases, which can be nano-formulated using curcumin, quercetin, resveratrol, rutin, piperine, gallic acid, ferulic acid, and selenium [95].…”

Section: Phytomedicine and Human Healthmentioning

confidence: 99%

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

et al. 2022

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The Kingdom of Plantae is considered the main source of human food, and includes several edible and medicinal plants, whereas mushrooms belong to the Kingdom of fungi. There are a lot of similar characteristics between mushrooms and higher plants, but there are also many differences among them, especially from the human health point of view. The absences of both chlorophyll content and the ability to form their own food are the main differences between mushrooms and higher plants. The main similar attributes found in both mushrooms and higher plants are represented in their nutritional and medicinal activities. The findings of this review have a number of practical implications. A lot of applications in different fields could be found also for both mushrooms and higher plants, especially in the bioenergy, biorefinery, soil restoration, and pharmaceutical fields, but this study is the first report on a comparative photographic review between them. An implication of the most important findings in this review is that both mushrooms and plants should be taken into account when integrated food and energy are needed. These findings will be of broad use to the scientific and biomedical communities. Further investigation and experimentation into the integration and production of food crops and mushrooms are strongly recommended under different environmental conditions, particularly climate change.

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“…With the advancement of medical nanotechnology, the precision and efficiency of drug delivery are improving tremendously. This has brought new hope for the application of “old” drugs, such as herbal drugs and pnictogen-based drugs [ 19 , 20 ]. Various nanomaterials have been shown to improve drug delivery to the brain [ 21 , 22 ], and several BBB-compliant strategies have been developed based on its physiology.…”

Section: Introductionmentioning

confidence: 99%

Anti-Parkinsonian Therapy: Strategies for Crossing the Blood–Brain Barrier and Nano-Biological Effects of Nanomaterials

Cheng

Liu

et al. 2022

Nano-Micro Lett.

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Parkinson’s disease (PD), a neurodegenerative disease that shows a high incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no clinical cure for PD, and novel anti-PD drugs are therefore urgently required. However, the selective permeability of the blood–brain barrier (BBB) poses a huge challenge in the development of such drugs. Fortunately, through strategies based on the physiological characteristics of the BBB and other modifications, including enhancement of BBB permeability, nanotechnology can offer a solution to this problem and facilitate drug delivery across the BBB. Although nanomaterials are often used as carriers for PD treatment, their biological activity is ignored. Several studies in recent years have shown that nanomaterials can improve PD symptoms via their own nano-bio effects. In this review, we first summarize the physiological features of the BBB and then discuss the design of appropriate brain-targeted delivery nanoplatforms for PD treatment. Subsequently, we highlight the emerging strategies for crossing the BBB and the development of novel nanomaterials with anti-PD nano-biological effects. Finally, we discuss the current challenges in nanomaterial-based PD treatment and the future trends in this field. Our review emphasizes the clinical value of nanotechnology in PD treatment based on recent patents and could guide researchers working in this area in the future.

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Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

Cited by 111 publications

References 424 publications

Research progress on self-assembled nanodrug delivery systems

Research progress on self-assembled nanodrug delivery systems

A Comparative Photographic Review on Higher Plants and Macro-Fungi: A Soil Restoration for Sustainable Production of Food and Energy

Anti-Parkinsonian Therapy: Strategies for Crossing the Blood–Brain Barrier and Nano-Biological Effects of Nanomaterials

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