Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Abstract

The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

Evaluation of cholinesterase inhibitory and antioxidant activity of Wedelia chinensis and isolation of apigenin as an active compound

“…To gain insights into the compounds responsible for activity, we explored the bioactive compounds in EAF by bioassay-guided chromatography. A major active compound was isolated from EAF and its structure was established as apigenin by 1 H-and 13 C-NMR spectral studies (Table 3, Fig. 5 and supplementary Fig.…”

“…Fraction F2 with potent AChE and BChE inhibitory activity was purified on silica gel GF 254 by preparative thin layer chromatography with n-hexane-acetone (6:4) as the mobile phase to obtain the pure compound 1 (18 mg). 1 H-and 13 C-NMR spectra of the compound 1 was recorded in DMSO-d 6 on a Jeol-Ex 400 MHz and FT-NMR 100 MHz spectrometers. The chemical structure of the compound 1 was confirmed by comparing its spectral data with the reported values in the literature [36].…”

“…Medicinal plant has been used as folk medicine in many countries for the management of various diseases. In Bangladesh, the majority of the population depends on traditional plant-based medicines for the management of various ailments including neurodegenerative disorders [1]. There are about 1000 plant species in the country that have been recorded to have medicinal qualities, out of which 250 are regularly used in medicines [2].…”

Phytochemical Analysis, In Vitro Anticholinesterase, Antioxidant Activity and In Vivo Nootropic Effect of Ferula ammoniacum (Dorema ammoniacum) D. Don. in Scopolamine-Induced Memory Impairment in Mice

“…Previous studies have highlighted the potential beneficial effects of plants as vital sources for cholinesterase inhibitors [ 6 ]. Individuals suffering from neurological disorders in the developing and underdeveloped countries primarily rely on traditional herbal medicines [ 7 ]. The folkloric knowledge about plants have helped in isolation of a large number of bioactive compounds from various medicinal plants for example Galantamine, a potential inhibitor of acetylcholinesterase that have been isolated from Galanthus nivalis and is frequently used to treat AD [ 8 ].…”

Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice

“…However, we can use herbal medicines to approach this disease [5,10]. So focusing on traditional herbal medicine is a common fashion nowadays [38]. For example, compounds derived from medicinal plants have immunomodulatory effects; people have been using them safely since ancient times [19].…”