Traditional herbal remedies used by South African women for gynaecological complaints

Steenkamp, Vanessa

doi:10.1016/s0378-8741(03)00053-9

Cited by 146 publications

(107 citation statements)

References 10 publications

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“…Figure 3 shows the results for formalin-induced paw licking nociceptive test in mice at two dose levels of 500 and 1000 mg/kg, p.o. The extracts of the leaf and rhizome significantly [(p<0.01; F (5,30) =4.46)] reduced paw lickings in the mice compared to vehicle in the first phase (neurogenic phase) and significantly [(p<0.05-p<0.01; F (5,30) =7.46)] reduces the paw-licking in the second phase of the formalin-induced nociception. These results indicate that the two extracts displayed significant analgesic activities in this model.…”

Section: Acute Toxicity Effect Of the Aqueous Dried Leaf And Rhizome mentioning

confidence: 99%

“…In almost all the towns and cities in South Africa, traditional medicines are also available widely and sometimes they can be sourced in specially designated markets known as "muthi" markets and traditional specialists' shops (Steenkamp, 2003). Orthodox medicine and some scientists believed that the methods of traditional knowledge and practices are primitive and backward (Conserve Africa, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Screening, Anti-Inflammatory and Analgesic Properties of Pentanisia Prunelloides From the Eastern Cape Province, South Africa

Mathews¹,

Oyemitana²,

Opeoluwa³

et al. 2016

Afr J Tradit Complement Altern Med

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Background Pentanisia prunelloides is a medicinal plant widely used to remedy various ailments including infections, fever and rheumatism in Eastern Cape Province of South Africa. There is scanty report on the phytochemical and biological properties of the plant; hence various solvent extracts of the dried plant materials were phytochemically screened, and its aqueous extract evaluated for acute toxicity effect, analgesic and antiinflammatory properties in rodents. Methods and Materials: Different extracts of both leaf and rhizome were obtained separately with ethanol, methanol and water. Portions of the filtrate were used for qualitative screening of secondary metabolites and remaining portions were concentrated and dried. Dried grounded leaf and rhizome of the plant were also used for quantitative screening for some major components. The aqueous extract of the leaf and rhizome were used for acute toxicity (LD 50 ) test, antiinflammatory and analgesic activities in rodents. Results: The qualitative phytochemical screening showed the presence of several phytoconstituents with saponins, flavonoids and alkaloids constituting highest constituents in the leaf and rhizome. The LD 50 of the aqueous extracts (from leaf or rhizome) was found to be ≥5000 mg/kg orally. The leaf and rhizome aqueous extract (250-500 mg/kg) significantly (p<0.01) reduced egg albumininduced paw oedema and paw licking in mice induced by formalin, signifying antinociceptive and antiinflammatory activities respectively. Conclusion It is concluded that the leaf and rhizome of P. prunelloides are rich in various phytochemicals which could be associated with their medicinal uses. The aqueous leaf and rhizome extracts are similarly non-toxic orally, showed antiinflammatory and analgesic potentials thus rationalizing its use in folkloric medicine.

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Section: Acute Toxicity Effect Of the Aqueous Dried Leaf And Rhizome mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Anti-Inflammatory and Analgesic Properties of Pentanisia Prunelloides From the Eastern Cape Province, South Africa

Mathews¹,

Oyemitana²,

Opeoluwa³

et al. 2016

Afr J Tradit Complement Altern Med

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“…Ethno-botanically, the root or stem bark has been used to treat mouth ulcers and tooth ache (Steyn et al, 1998). Decoction of the leaves or root has found application in the treatment of fever, influenza, bronchitis, colds and infertility (Steyn et al, 1998;Steenkamp, 2003). Other uses include the treatment of syphilis, gastro-intestinal disorders, flatulent colic and epilepsy (van Wyk et al, 1997; Amabeoku and Kinyua, 2010).…”

Section: Introductionmentioning

confidence: 99%

Germination response of <i>Zanthoxylum capense</i> (small knobwood) seeds to different pre-treatment protocols

Bodede¹,

Shaik²,

Moodley³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Zanthoxylum capense is an important medicinal species in South Africa. It is propagated by seeds which are dispersed by different animals but the seeds rarely germinate even under favourable germination conditions which could be the result of dormancy. In addition, the species is currently listed as threatened in the Red List of South African Plants; therefore, it is of importance to find ways of promoting its propagation. Materials and Methods: The germination of Z. capense seeds in response to different scarification and stratification pre-sowing treatments was studied. Seed stratification included chilling at 4 o C. Seed scarification was performed mechanically, using hot and cold water, and using hydrochloric acid and sulphuric acid. Results: The highest final germination percentage (FGP) (71.1%) was obtained from seeds soaked in hot water for 15 minutes and grown in dark conditions. The 30 days chilling treatment also gave a good response (57.8%) when grown under light or dark conditions. Other FGPs of note included seeds soaked with 500 ppm gibberellic acid (GA 3 ) (60%, light; 44.4%, dark) and 1000 ppm GA 3 (46.7%, light; 48.9%, dark) and soaking in H 2 SO 4 for 5 minutes (42.2%, dark). Overall, the seeds sown under dark conditions produced better FGPs than those sown in light. Conclusion: These results reveal that Z. capense seeds display combinational dormancy that imposed physically by the seed coat and that imposed physiologically by the embryo. These dormancy traits can be easily overcome by either chilling or soaking in hot water or GA 3 .

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“…It is widely sought after by indigenous South Africans for numerous medical conditions including dermatological disorders, sore eyes, urinary complications, infertility, facilitation and induction of abortion (Steenkamp, 2003). Some studies have claimed that its extracts demonstrated moderate in vitro antibacterial and antifungal activity (Buwa et al, 2006; Van Vuuren and Naidoo, 2010).…”

Section: Introductionmentioning

confidence: 99%

The inhibitory activity of the extracts of popular medicinal herbs on CYP1A2, 2C9, 2C19 and 3A4 and the implications for herb-drug interaction

Fasinu

Bouic

Rosenkranz

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Studies have suggested an increasing practice of concurrent herb-drug consumption. One of the major clinical risks of such concomitant herb-drug use is pharmacokinetic herb-drug interaction (HDI). This is brought about by the ability of phytochemicals to inhibit or induce the activity of metabolic enzymes. The aim of this study was to investigate the potential of the crude aqueous extracts of three popular medicinal herbs used in South Africa to inhibit major cytochrome P450 (CYP) enzymes. Materials and Methods:The extracts of Bowiea volubilis, Spirostachys africana and Tulbaghia violacea were incubated with human liver microsomes (HLM) to monitor the phenacetin O-deethylation, diclofenac 4'-hydroxylation, S-mephenytoin 4'-hydroxylation and testosterone 6β-hydroxylation as respective probe reactions for CYP1A2, CYP2C9, CYP2C19 and CYP3A4. The inhibitory activity, where observed, was profiled against the extract concentration. Results: Extracts of Bowiea volubilis inhibited the metabolic activity of CYP1A2 and CYP3A4 with IC 50 values of 92.3 ± 5.5 g/mL and 8.1 ± 0.6 g/mL respectively. Similar observation with Spirostachys africana showed inhibitory activity against CYP1A2 and CYP3A4 with respective IC 50 values of 14.3 ± 0.6 g/mL and 47.4 ± 2.4 g/mL. Tulbaghia violacea demonstrated relatively weak inhibitory activity against CYP1A2 (767.4 ± 10.8 g/mL) and CYP2C9 (921 ± 15.3 g/mL). Conclusion:The results suggest the potential for HDI between the herbs and the substrates of the affected enzymes, if sufficient in vivo concentration is attained.

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Traditional herbal remedies used by South African women for gynaecological complaints

Cited by 146 publications

References 10 publications

Phytochemical Screening, Anti-Inflammatory and Analgesic Properties of Pentanisia Prunelloides From the Eastern Cape Province, South Africa

Phytochemical Screening, Anti-Inflammatory and Analgesic Properties of Pentanisia Prunelloides From the Eastern Cape Province, South Africa

Germination response of <i>Zanthoxylum capense</i> (small knobwood) seeds to different pre-treatment protocols

The inhibitory activity of the extracts of popular medicinal herbs on CYP1A2, 2C9, 2C19 and 3A4 and the implications for herb-drug interaction

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