Traditional knowledge of wild medicinal plants used by the inhabitants of Garam Chashma valley, district Chitral, Pakistan

Birjees, Maimoona; Ahmad, Mushtaq; Zafar, Muhammad; Nawaz, Sumra; Jehanzeb, Sahira; Ullah, Fazal; Zaman, Wajid

doi:10.1016/j.chnaes.2020.12.006

Cited by 39 publications

(37 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these, maximum number of plants were being used for stomachache followed by diarrhea, constipation, and intestinal worms. Previous studies also confirmed the treatment of GIDs using local medicinal plants [12,[67][68][69][70]. The results suggest that locals prefer plant-based remedies for the treatment of GIDs, as in most of the cases herbal preparations provide instant relief without any significant side effect.…”

Section: Discussionsupporting

confidence: 53%

Untitled

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 53%

Untitled

View full text Add to dashboard Cite

“…Unlike in Western medicines in which pure bioactive compounds are used in pharmaceutical products, traditional medicine utilizes crude forms of whole plants or plant parts. The various plants and herbal products utilized in traditional/herbal medicine differ due to differences in climate and culture [ 12 , 13 ]. Consequently, analytical methods for herbal products developed in one country are not applicable in another country.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study

Kaggwa

Kyeyune

Munanura

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. The Uganda National Drug Authority requires phytochemical screening, freedom from microbial contamination, and evidence of safety and efficacy of the constituent plants to register herbal products. Since Uganda has no pharmacopeia, safety, efficacy, and plant processing information are not readily available. We documented the plant materials used to manufacture products in Uganda and established evidence of their safety and efficacy and availability of monographs. Methods. The NDA register of herbal products was reviewed, and a product list was extracted. The herbal products were purchased from local pharmacies, and their labels were studied to identify plant ingredients and drug use. Literature was reviewed to document evidence of the safety and efficacy of the plant materials concerning manufacturer’s claims. Also, the WHO and available African Pharmacopeia were searched to establish the availability of the plant monographs. Results. Of the 84 NDA-registered local products, only 18 were obtained from the market; 82% were indicated for respiratory tract disorders. Thirty-three plant materials were listed with Eucalyptus globulus Labill, being the commonest. Several in vitro and in vivo studies demonstrate efficacy, thus supporting the use of the selected plant species for empirical treatment as stated on the product label. While most plants were safe, some species such as Albizia coriaria Oliv. had dose-dependent toxicities that cannot be predicted in combinations. The WHO, African Pharmacopoeia, and West African Herbal Pharmacopoeia had only 16 plant monographs of the 33 plants of interest. Nevertheless, Aloe vera (L.) Burm.f., Azadirachta indica A.Juss., Zingiber officinale Roscoe, and Allium sativum L. monographs were published by all three pharmacopoeias. Conclusions. Preclinical evidence of safety and efficacy exists in the literature for most of the plants used to manufacture registered herbal products in Uganda. More specific bioassays and clinical trials are required for the products to provide conclusive evidence of safety and toxicity. Monographs are urgently needed for the Ugandan plants.

show abstract

“…To date, native people of the developing countries rely on the use of medicinal herbs to manage their healthcare issues [ 21 ]. For these people this kind of practice represents a value for its tradition and long-term belief of its effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy

2022

View full text Add to dashboard Cite

Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably high. The standard drug combination used to treat this bone cancer has remained the same for the last 20 years, and it produces many dangerous side effects. Through history, from ancient to modern times, nature has been a remarkable source of chemical diversity, used to alleviate human disease. The application of modern scientific technology to the study of natural products has identified many specific molecules with anti-cancer properties. This review describes the latest discovered anti-cancer compounds extracted from traditional medicinal plants, with a focus on osteosarcoma research, and on their cellular and molecular mechanisms of action. The presented compounds have proven to kill osteosarcoma cells by interfering with different pathways: apoptosis induction, stimulation of autophagy, generation of reactive oxygen species, etc. This wide variety of cellular targets confer natural products the potential to be used as chemotherapeutic drugs, and also the ability to act as sensitizers in drug combination treatments. The major hindrance for these molecules is low bioavailability. A problem that may be solved by chemical modification or nano-encapsulation.

show abstract

Traditional knowledge of wild medicinal plants used by the inhabitants of Garam Chashma valley, district Chitral, Pakistan

Cited by 39 publications

References 47 publications

Untitled

Untitled

Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study

Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy

Contact Info

Product

Resources

About